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Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells
Whether CD8-lineage specification and CD8+ T cell differentiation is dependent on intrathymic cytokines signaling is unclear. Singer and co-workers show that interleukin 7 specifies CD8-lineage choice and promote...
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Article
'Coreceptor tuning': cytokine signals transcriptionally tailor CD8 coreceptor expression to the self-specificity of the TCR
T cell immunity requires the long-term survival of T cells that are capable of recognizing self antigens but are not overtly autoreactive. How this balance is achieved remains incompletely understood. Here we ...