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    Article

    Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells

    Whether CD8-lineage specification and CD8+ T cell differentiation is dependent on intrathymic cytokines signaling is unclear. Singer and co-workers show that interleukin 7 specifies CD8-lineage choice and promote...

    Jung-Hyun Park, Stanley Adoro, Terry Guinter, Batu Erman, Amala S Alag… in Nature Immunology (2010)

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    Article

    'Coreceptor tuning': cytokine signals transcriptionally tailor CD8 coreceptor expression to the self-specificity of the TCR

    T cell immunity requires the long-term survival of T cells that are capable of recognizing self antigens but are not overtly autoreactive. How this balance is achieved remains incompletely understood. Here we ...

    Jung-Hyun Park, Stanley Adoro, Philip J Lucas, Sophia D Sarafova… in Nature Immunology (2007)