15 Result(s)
within
Petros C. Karakousis
English
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Article
Open AccessAlbumin fusion with granulocyte-macrophage colony-stimulating factor acts as an immunotherapy against chronic tuberculosis
A long duration of treatment and emerging drug resistance pose significant challenges for global tuberculosis (TB) eradication efforts. Therefore, there is an urgent need to develop novel strategies to shorten...
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Article
Open AccessThe association of atherosclerotic cardiovascular disease and statin use with inflammation and treatment outcomes in tuberculosis
Tuberculosis (TB) and atherosclerotic cardiovascular disease (ASCVD) have a close epidemiological and pathogenetic overlap. Thus, it becomes essential to understand the relationship between ASCVD and TB outcom...
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Article
Open AccessModes of transmission of SARS-CoV-2 and evidence for preventive behavioral interventions
COVID-19 is a novel disease caused by SARS-CoV-2. During the global vaccination rollout, it is vital to thoroughly understand the modes of transmission of the virus in order to prevent further spread of varian...
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Chapter
Statins as Host-Directed Therapy for Tuberculosis
Statins are a class of drugs that inhibit HMG-CoA reductase, the rate-limiting step in cholesterol biosynthesis, and are commonly used for primary and secondary prevention of cardiovascular disease. In additio...
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Article
Open AccessIntegration of metabolomics and transcriptomics reveals novel biomarkers in the blood for tuberculosis diagnosis in children
Pediatric tuberculosis (TB) remains a major global health problem. Improved pediatric diagnostics using readily available biosources are urgently needed. We used liquid chromatography-mass spectrometry to anal...
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Article
Treatment with an immature dendritic cell-targeting vaccine supplemented with IFN-α and an inhibitor of DNA methylation markedly enhances survival in a murine melanoma model
The chemokine MIP-3α (CCL20) binds to CCR6 on immature dendritic cells. DNA vaccines fusing MIP-3α to melanoma-associated antigens have shown improved efficacy and immunogenicity in the B16F10 mouse melanoma m...
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Article
Open AccessIdentifying the essential genes of Mycobacterium avium subsp. hominissuis with Tn-Seq using a rank-based filter procedure
Mycobacterium avium subsp. hominissuis (MAH) is increasingly recognized as a significant cause of morbidity, particularly in elderly patients or those with immune deficiency or underlying lung impairment. Disease...
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Open AccessGenome analysis of Mycobacterium avium subspecies hominissuis strain 109
Infection with Mycobacterium avium is a significant cause of morbidity and its treatment requires the use of multiple antibiotics for more than 12 months. In the current work, we provide the genome sequence, gene...
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Clinical Features and Diagnosis of Tuberculosis: Primary Infection and Progressive Pulmonary Tuberculosis
In this chapter, we will review the clinical manifestations of intrathoracic tuberculosis (TB), including pathophysiology and clinical features of primary and secondary or reactivation TB. Specific topics disc...
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Article
Open AccesssenX3-independent contribution of regX3 to Mycobacterium tuberculosis virulence
Mycobacterium tuberculosis (Mtb) must adapt to various stress conditions during host infection. The two-component regulatory system (2CRS) SenX3-RegX3 is required for Mtb virulence. We showed recently that the s...
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Article
Open AccessEarly innate immunity determines outcome of Mycobacterium tuberculosis pulmonary infection in rabbits
Pulmonary infection of humans by Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), results in active disease in 5-10% of individuals, while asymptomatic latent Mtb infection (LTBI) is es...
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Article
Open AccessMolecular immunologic correlates of spontaneous latency in a rabbit model of pulmonary tuberculosis
Infection of humans with Mycobacterium tuberculosis (Mtb) results in latent tuberculosis infection (LTBI) in 90-95% of immune competent individuals, with no symptoms of active disease. The World Health Organizati...
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Chapter
Mechanisms of Action and Resistance of Antimycobacterial Agents
Historically, mycobacterial infections have been associated with signifi cant morbidity and mortality worldwide. In particular, Mycobacterium tuberculosis is a highly successful human pathogen, infecting one-thir...
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Article
Open AccessMycobacterium avium complex immune reconstitution inflammatory syndrome: Long term outcomes
To describe long term outcomes of Mycobacterium avium complex (MAC) immune reconstitution inflammatory syndrome (IRIS).
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Open AccessU.S. medical resident familiarity with national tuberculosis guidelines
The ability of medical residents training at U.S. urban medical centers to diagnose and manage tuberculosis cases has important public health implications. We assessed medical resident knowledge about tubercul...
