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Article
Joint-specific memory, resident memory T cells and the rolling window of opportunity in arthritis
In rheumatoid arthritis, juvenile idiopathic arthritis and other forms of inflammatory arthritis, the immune system targets certain joints but not others. The pattern of joints affected varies by disease and b...
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Article
Open AccessNon-coding autoimmune risk variant defines role for ICOS in T peripheral helper cell development
Fine-map** and functional studies implicate rs117701653, a non-coding single nucleotide polymorphism in the CD28/CTLA4/ICOS locus, as a risk variant for rheumatoid arthritis and type 1 diabetes. Here, using DNA...
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Article
Recent advances and evolving concepts in Still’s disease
Still’s disease is a rare inflammatory syndrome that encompasses systemic juvenile idiopathic arthritis and adult-onset Still’s disease, both of which can exhibit life-threatening complications, including macr...
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Article
Open AccessThe 4th NextGen Therapies for SJIA and MAS: part 1 the elephant in the room: diagnostic/classification criteria for systemic juvenile idiopathic arthritis and adult-onset still’s disease
Currently, the criteria used to classify patients with SJIA are different from those used for AOSD. However, it has been recognized that the existing terms are too narrow, subdividing the Still’s population un...
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Article
Open AccessHuman and mouse neutrophils share core transcriptional programs in both homeostatic and inflamed contexts
Neutrophils are frequently studied in mouse models, but the extent to which findings translate to humans remains poorly defined. In an integrative analysis of 11 mouse and 13 human datasets, we find a strong c...
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Article
Open AccessFirst-line options for systemic juvenile idiopathic arthritis treatment: an observational study of Childhood Arthritis and Rheumatology Research Alliance Consensus Treatment Plans
The Childhood Arthritis and Rheumatology Research Alliance (CARRA) developed consensus treatment plans (CTPs) to compare treatment initiation strategies for systemic juvenile idiopathic arthritis (sJIA). First...
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Article
Open AccessmTORC1 links pathology in experimental models of Still’s disease and macrophage activation syndrome
Still’s disease is a severe inflammatory syndrome characterized by fever, skin rash and arthritis affecting children and adults. Patients with Still’s disease may also develop macrophage activation syndrome, a...
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Article
Implications of Evolving Disease Classification for Drug Approval in Juvenile Idiopathic Arthritis
The classification of inflammatory arthritis incorporates a sharp divide between diseases of childhood onset, grouped together as juvenile idiopathic arthritis, and diseases such as rheumatoid arthritis that b...
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Article
Open AccessProteomics based markers of clinical pain severity in juvenile idiopathic arthritis
Juvenile idiopathic arthritis (JIA) is a cluster of autoimmune rheumatic diseases occurring in children 16 years of age or less. While it is well-known that pain may be experienced during inflammatory and non-...
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Article
Genome editing to define the function of risk loci and variants in rheumatic disease
Discoveries in human genetic studies have revolutionized our understanding of complex rheumatic and autoimmune diseases, including the identification of hundreds of genetic loci and single nucleotide polymorph...
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Article
Repression of CTSG, ELANE and PRTN3-mediated histone H3 proteolytic cleavage promotes monocyte-to-macrophage differentiation
Chromatin undergoes extensive reprogramming during immune cell differentiation. Here we report the repression of controlled histone H3 amino terminus proteolytic cleavage (H3ΔN) during monocyte-to-macrophage d...
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Article
Open AccessThe neutrotime transcriptional signature defines a single continuum of neutrophils across biological compartments
Neutrophils are implicated in multiple homeostatic and pathological processes, but whether functional diversity requires discrete neutrophil subsets is not known. Here, we apply single-cell RNA sequencing to n...
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Article
Publisher Correction: Biological classification of childhood arthritis: roadmap to a molecular nomenclature
A Correction to this paper has been published: https://doi.org/10.1038/s41584-021-00610-5.
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Article
Biological classification of childhood arthritis: roadmap to a molecular nomenclature
Chronic inflammatory arthritis in childhood is heterogeneous in presentation and course. Most forms exhibit clinical and genetic similarity to arthritis of adult onset, although at least one phenotype might be...
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Chapter
Estrogen-Driven Changes in Immunoglobulin G Fc Glycosylation
Glycosylation within the immunoglobulin G (IgG) Fc region modulates its ability to engage complement and Fc receptors, affording the opportunity to fine-tune effector functions. Mechanisms regulating IgG Fc gl...
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Article
Open AccessEarly progression to active tuberculosis is a highly heritable trait driven by 3q23 in Peruvians
Of the 1.8 billion people worldwide infected with Mycobacterium tuberculosis, 5–15% will develop active tuberculosis (TB). Approximately half will progress to active TB within the first 18 months after infection,...
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Article
Open AccessZFYVE21 is a complement-induced Rab5 effector that activates non-canonical NF-κB via phosphoinosotide remodeling of endosomes
Complement promotes vascular inflammation in transplant organ rejection and connective tissue diseases. Here we identify ZFYVE21 as a complement-induced Rab5 effector that induces non-canonical NF-κB in endoth...
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Article
Open AccessCalm in the midst of cytokine storm: a collaborative approach to the diagnosis and treatment of hemophagocytic lymphohistiocytosis and macrophage activation syndrome
Hemophagocytic lymphohistiocytosis (HLH) and macrophage activation syndrome (MAS) were historically thought to be distinct entities, often managed in isolation. In fact, these conditions are closely related. A...
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Chapter
Systemic Juvenile Idiopathic Arthritis and Adult Onset Still Disease
Systemic juvenile idiopathic arthritis (sJIA) and adult onset Still disease (AOSD) are characterized by the triad of fever, rash and arthritis, together with high-grade systemic inflammation and other manifest...
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Article
Fine-map** and functional studies highlight potential causal variants for rheumatoid arthritis and type 1 diabetes
To define potentially causal variants for autoimmune disease, we fine-mapped1,2 76 rheumatoid arthritis (11,475 cases, 15,870 controls)3 and type 1 diabetes loci (9,334 cases, 11,111 controls)4. After sequencing ...
