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Fine-map** and functional studies highlight potential causal variants for rheumatoid arthritis and type 1 diabetes
To define potentially causal variants for autoimmune disease, we fine-mapped1,2 76 rheumatoid arthritis (11,475 cases, 15,870 controls)3 and type 1 diabetes loci (9,334 cases, 11,111 controls)4. After sequencing ...
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High-throughput identification of noncoding functional SNPs via type IIS enzyme restriction
Genome-wide association studies (GWAS) have identified many disease-associated noncoding variants, but cannot distinguish functional single-nucleotide polymorphisms (fSNPs) from others that reside incidentally...
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Article
Open AccessFunctionally distinct disease-associated fibroblast subsets in rheumatoid arthritis
Fibroblasts regulate tissue homeostasis, coordinate inflammatory responses, and mediate tissue damage. In rheumatoid arthritis (RA), synovial fibroblasts maintain chronic inflammation which leads to joint dest...
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Open AccessAge and fecal microbial strain-specific differences in patients with spondyloarthritis
Prior studies have demonstrated abnormalities in the composition of the gastrointestinal microbiota in pediatric and adult patients with spondyloarthritis (SpA). In particular, diminished fecal abundance of Faeca...
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Open AccessProceedings of the 23rd Paediatric Rheumatology European Society Congress: part one
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Open AccessPilot study comparing the Childhood Arthritis & Rheumatology Research Alliance (CARRA) systemic Juvenile Idiopathic Arthritis Consensus Treatment Plans
To assess the feasibility of studying the comparative effectiveness of the Childhood Arthritis and Rheumatology Research Alliance (CARRA) consensus treatment plans (CTPs) for systemic Juvenile Idiopathic Arthr...
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Article
Pathologically expanded peripheral T helper cell subset drives B cells in rheumatoid arthritis
The authors identify in patients with rheumatoid arthritis a pathogenic subset of CD4+ T cells that augments B cell responses within inflamed tissues.
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Open AccessRevealing the diversity of extracellular vesicles using high-dimensional flow cytometry analyses
Extracellular vesicles (EV) are small membrane vesicles produced by cells upon activation and apoptosis. EVs are heterogeneous according to their origin, mode of release, membrane composition, organelle and bi...
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Article
Open AccessProceedings of the 2016 Childhood Arthritis and Rheumatology Research Alliance (CARRA) Scientific Meeting
P1 Serologic evidence of gut-driven systemic inflammation in juvenile idiopathic arthritis
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Open AccessEnthesitis as a component of dactylitis in psoriatic juvenile idiopathic arthritis: histology of an established clinical entity
Imaging of dactylitis in adult psoriatic arthritis suggests a pathophysiological role for enthesitis. However, histological definition of the dactylitic digit is unavailable.
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Dense genoty** of immune-related disease regions identifies 14 new susceptibility loci for juvenile idiopathic arthritis
Anne Hinks and colleagues identify 14 new susceptibility loci for juvenile idiopathic arthritis through targeted analyses of genomic regions implicated in immune function. Their study implicates several pathwa...
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Platelets: active players in the pathogenesis of arthritis and SLE
Platelets have an established function in haemostasis, but their role in the development of rheumatic disease is only now emerging. In this focused Review, Boilard and colleagues describe how platelets, and pl...
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Open AccessJuvenile idiopathic arthritis is associated with potentially pathogenic glycosylation of IgG
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Open AccessDisease characteristics and medication use in a multicenter cohort of children with juvenile idiopathic arthritis (JIA): preliminary analyses from the CARRAnet registry
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Open AccessDevelopment of consensus best treatment plans for new-onset systemic juvenile idiopathic arthritis
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Open AccessHypogalactosylation of serum N-glycans fails to predict clinical response to methotrexate and TNF inhibition in rheumatoid arthritis
Rheumatoid arthritis (RA) is associated with hypogalactosylation of immunoglobulin G (IgG). We examined whether a proxy measure for galactosylation of IgG N-glycans could predict response to therapy or was dif...
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Particularities of the vasculature can promote the organ specificity of autoimmune attack
How certain autoimmune diseases target specific organs remains obscure. In the 'K/BxN' arthritis model, autoantibodies to a ubiquitous antigen elicit joint-restricted pathology. Here we have used intravital im...
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Mast cells in inflammatory arthritis
Mast cells are present in limited numbers in normal human synovium, but in rheumatoid arthritis and other inflammatory joint diseases this population can expand to constitute 5% or more of all synovial cells. ...
