Management of Severe Traumatic Brain Injury
Evidence, Tricks, and Pitfalls
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Chapter
Temperature Management
Active hypothermia was introduced during the 1990s for treatment of traumatic head injury. This was based on the experience that hypothermia is protective to prevent ischaemia in different organs and being pro...
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Chapter
The Lund Therapy: A Physiological Approach
In principle, most guidelines for treatment of severe traumatic brain oedema (TBI), such as the Brain Trauma Foundation (US) guidelines, are based on a meta-analytic approach. The alternative that the guidelin...
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Chapter
Management of Fluids and Electrolytes
Normovolaemia is essential to maintain a normal catecholamine release and optimal perfusion in the penumbra zone of the injured brain. Both crystalloids and albumin can be used as plasma volume expanders. Be a...
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Chapter
Guidelines for Treatment of Patients with Severe Traumatic Brain Injury
The present chapter summarizes the different components of the most common guidelines for treatment of a severe brain trauma that have been available for the last two decades.
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Article
Open AccessIsolated Brain Trauma in Cats Triggers Rapid Onset of Hypovolemia
Hemodynamic instability responsive to fluid resuscitation is common after a traumatic brain injury (TBI), also in the absence of systemic hemorrhage. The present study tests if an isolated severe TBI induces a...
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Article
Open AccessThe effect of vitamin C on plasma volume in the early stage of sepsis in the rat
Previous experimental studies have shown that vitamin C has several beneficial effects in sepsis and burns, such as decreased tissue oedema, improved endothelial barrier function and decreased transcapillary l...
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Article
Intracranial pressure monitoring in traumatic brain injury
A randomized study has indicated that continuous monitoring of intracranial pressure (ICP) in patients with traumatic brain injury does not improve outcome compared with care based on imaging and clinical exam...
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Article
Open AccessThe effects of continuous prostacyclin infusion on regional blood flow and cerebral vasospasm following subarachnoid haemorrhage: study protocol for a randomised controlled trial
One of the main causes of mortality and morbidity following subarachnoid haemorrhage (SAH) is the development of cerebral vasospasm, a frequent complication arising in the weeks after the initial bleeding. Des...
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Article
The G protein-coupled oestrogen receptor 1 agonist G-1 disrupts endothelial cell microtubule structure in a receptor-independent manner
The G protein-coupled oestrogen receptor GPER1, also known as GPR30, has been implicated in oestrogen signalling, but the physiological importance of GPER1 is not fully understood. The GPER1 agonist G-1 has be...
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Book
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Chapter
Comparative Analysis of Various Guidelines for Treatment of Severe TBI
Various guidelines have been presented during the last 20 years for treatment of severe TBI in the adult. The Rosner protocol (Rosner et al. 1995), the Lund concept (Asgeirsson et al. 1994), the US guideline (...
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Chapter
Body Temperature in TBI Patients
Based on experimental and clinical studies, there is a general view that fever is detrimental to TBI patients (Thompson et al. 2003). An important goal in the treatment of these patients has therefore been to ...
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Chapter
The Lund Therapy for Severe Head Trauma
There have been no Level I studies performed to evaluate the Lund therapy relative to more conventional treatments.
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Chapter
Fluid Haemodynamics in Patients with Severe TBI
The support for saline or other crystalloid solutions as the main plasma volume expanders in TBI patients is supported by the results of the SAFE-TBI study. This fluid regimen is cheaper than other fluid regimens...
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Article
Effect of blood pressure on plasma volume loss in the rat under increased permeability
To evaluate the effects of change in blood pressure on plasma volume under increased permeability.
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Article
The Lund concept: a well-defined therapy within the prescribed norms
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Article
Plasma volume expansion of 5% albumin, 4% gelatin, 6% HES 130/0.4, and normal saline under increased microvascular permeability in the rat
To compare the colloids 5% albumin, 4% gelatin, and 6% HES 130/0.4 with one another and with normal saline regarding their plasma expanding effects at increased permeability and to compare the results with tho...
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Article
The “Lund Concept” for the treatment of severe head trauma – physiological principles and clinical application
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Article
Use of steroids to reduce high fever in head injury—is it acceptable?
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Article
The “Lund Concept” for the treatment of severe head trauma – physiological principles and clinical application
The Lund Concept is an approach to the treatment of severe brain trauma that is mainly based on hypotheses originating from basic physiological principles regarding brain volume and cerebral perfusion regulati...
