Abstract
Active hypothermia was introduced during the 1990s for treatment of traumatic head injury. This was based on the experience that hypothermia is protective to prevent ischaemia in different organs and being protective after drowning in cold water. Several studies have been performed to evaluate the effect of active hypothermia after severe brain trauma. The best randomised studies, however, could not show improved outcome by hypothermia. This chapter will give some possible explanations why the expected general protective effect of active hypothermia does not seem to be valid in severe head injury. The use of pharmacological substances to affect the thermostat to reduce high fever is discussed.
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Grände, PO., Reinstrup, P. (2020). Temperature Management. In: Sundstrøm, T., Grände, PO., Luoto, T., Rosenlund, C., Undén, J., Wester, K. (eds) Management of Severe Traumatic Brain Injury. Springer, Cham. https://doi.org/10.1007/978-3-030-39383-0_68
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