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Article
Open AccessSmoking in pregnancy, cord blood cotinine and risk of celiac disease diagnosis in offspring
Ecological observations suggest an inverse relationship between smoking in pregnancy and celiac disease (CD) in offspring. While individual-level analyses have been inconsistent, they have mostly lacked statis...
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Article
Serum B6 vitamers (pyridoxal 5′-phosphate, pyridoxal, and 4-pyridoxic acid) and pancreatic cancer risk: two nested case–control studies in Asian populations
Vitamin B6 is an important enzymatic cofactor in pathways relevant for the development of pancreatic cancer. In order to evaluate vitamin B6 as a preventive factor for pancreatic cancer, a biomarker approach is n...
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Chapter
The Hordaland Homocysteine Study: Lifestyle and Total Plasma Homocysteine in Western Norway
The Hordaland Homocysteine Study is a cohort of approximately 18,000 men and women, ages 40–67, who had their total plasma homocysteine (tHcy) determined in 1992 or 1993. The long-term aim of the study is to r...
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Chapter
On the Formation and Fate of Total Plasma Homocysteine
The total concentration of homocysteine (tHcy)* in plasma is a useful marker of impaired function of cobalamin and folate. Moreover, it is an independent risk factor for atherosclerotic disease [1]. These find...
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Chapter
Homocysteine and Drug Therapy
Several agents other than vitamins involved in homocysteine (Hcy) metabolism affect plasma homocysteine (tHcy) total concentration. The mechanisms behind the hyperhomocysteinemia vary from altered homocysteine...
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Chapter
Perturbation of Homocysteine Metabolism by Pharmacological Agents in Experimental and Clinical Use
Homocysteine, a sulfur amino acid, was discovered over 50 years ago by DuVigneaud as the product of demethylation of methionine This discovery was followed by reports that homocysteine could support growth of ...