29 Result(s)

Article

Acute effects of oral mesna administration on the full amino acid profile and 3-methylhistidine: secondary results from the CYLOB dose-finding study

Plasma total cysteine (tCys) is strongly associated with fat mass in humans. Mesna lowers plasma tCys in a dose-dependent manner, but it is not known whether it interferes with metabolism of other amino acids ...

Thomas Olsen, Amany Elshorbagy, Emma Stolt, Anders Åsberg, Hasse K. Zaré… in Amino Acids (2024)

Article

Dietary sulfur amino acid restriction in humans with overweight and obesity: a translational randomized controlled trial

Dietary sulfur amino acid restriction (SAAR) improves metabolic health in animals. In this study, we investigated the effect of dietary SAAR on body weight, body composition, resting metabolic rate, gene expre...

Thomas Olsen, Emma Stolt, Bente Øvrebø… in Journal of Translational Medicine (2024)

Article

Correction to: The association of fasting plasma thiol fractions with body fat compartments, biomarker profile, and adipose tissue gene expression

Amany Elshorbagy, Nasser E. Bastani, Sindre Lee-Ødegård, Bente Øvrebø… in Amino Acids (2023)

Article

The importance of vitamin B₁₂ for individuals choosing plant-based diets

Vitamin B₁₂ is an essential nutrient that is not made by plants; consequently, unfortified plant-based foods are not a reliable supply. Recent estimates suggest high rates of vitamin B₁₂ deficiency among the vege...

Ali Niklewicz, A. David Smith, Alison Smith, Andre Holzer… in European Journal of Nutrition (2023)

Article

Associations between plasma sulfur amino acids and specific fat depots in two independent cohorts: CODAM and The Maastricht Study

Sulfur amino acids (SAAs) have been associated with obesity and obesity-related metabolic diseases. We investigated whether plasma SAAs (methionine, total cysteine (tCys), total homocysteine, cystathionine and...

Elena C. Tore, Amany K. Elshorbagy, Frans C. H. Bakers… in European Journal of Nutrition (2023)

Article

The association of fasting plasma thiol fractions with body fat compartments, biomarker profile, and adipose tissue gene expression

People with high plasma total cysteine (tCys) have higher fat mass and higher concentrations of the atherogenic apolipoprotein B (apoB). The disulfide form, cystine, enhanced human adipogenesis and correlated ...

Amany Elshorbagy, Nasser E. Bastani, Sindre Lee-Ødegård, Bente Øvrebø… in Amino Acids (2023)

Article

Extracellular cystine influences human preadipocyte differentiation and correlates with fat mass in healthy adults

Plasma cysteine is associated with human obesity, but it is unknown whether this is mediated by reduced, disulfide (cystine and mixed-disulfides) or protein-bound (bCys) fractions. We investigated which cystei...

Hagar Elkafrawy, Radwa Mehanna, Fayrouz Ali, Ayman Barghash, Iman Dessouky… in Amino Acids (2021)

Article

Sulfur amino acid restriction, energy metabolism and obesity: a study protocol of an 8-week randomized controlled dietary intervention with whole foods and amino acid supplements

Dietary sulfur amino acid (SAA) restriction is an established animal model for increasing lifespan and improving metabolic health. Data from human studies are limited. In the study outlined in this protocol, w...

Emma Stolt, Thomas Olsen, Amany Elshorbagy… in Journal of Translational Medicine (2021)

Article

Effects of short-term methionine and cysteine restriction and enrichment with polyunsaturated fatty acids on oral glucose tolerance, plasma amino acids, fatty acids, lactate and pyruvate: results from a pilot study

In this 7-day pilot study we randomized healthy, normal-weight men and women to either a dietary intervention with methionine and cysteine restriction enriched in PUFA (Met/Cys_low + PUFA, n = 7) or with high cont...

Thomas Olsen, Bente Øvrebø, Cheryl Turner, Nasser E. Bastani… in BMC Research Notes (2021)

Article

Branched-chain amino acid metabolism, insulin sensitivity and liver fat response to exercise training in sedentary dysglycaemic and normoglycaemic men

Obesity and insulin resistance may be associated with elevated plasma concentration of branched-chain amino acids (BCAAs) and impaired BCAA metabolism. However, it is unknown whether the insulin-sensitising ef...

Sindre Lee, Hanne L. Gulseth, Torgrim M. Langleite, Frode Norheim… in Diabetologia (2021)

Article

Creatinine, total cysteine and uric acid are associated with serum retinol in patients with cardiovascular disease

We hypothesized that biomarkers and dietary factors related to cardiovascular disease risk were associated with serum retinol and evaluated these potential associations in patients with suspected coronary arte...

Thomas Olsen, Kathrine J. Vinknes, Rune Blomhoff… in European Journal of Nutrition (2020)

Article

Postprandial effects of a meal low in sulfur amino acids and high in polyunsaturated fatty acids compared to a meal high in sulfur amino acids and saturated fatty acids on stearoyl CoA-desaturase indices and plasma sulfur amino acids: a pilot study

The sulfur amino acid (SAA) cysteine is positively related, whereas polyunsaturated fatty acids (PUFAs) are inversely related to activity of the lipogenic enzyme stearoyl-CoA desaturase (SCD). High SCD activit...

Thomas Olsen, Cheryl Turner, Bente Øvrebø, Nasser E. Bastani… in BMC Research Notes (2020)

Article

Vitamin B12 concentrations in milk from Norwegian women during the six first months of lactation

Human milk vitamin B12 (B12) concentrations depend on maternal status and intake; only few data are available in high-income countries.

Sigrun Henjum, Mari Manger, Daniela Hampel… in European Journal of Clinical Nutrition (2020)

Article

Effects of dietary methionine and cysteine restriction on plasma biomarkers, serum fibroblast growth factor 21, and adipose tissue gene expression in women with overweight or obesity: a double-blind randomized controlled pilot study

Dietary restriction of methionine and cysteine is a well-described model that improves metabolic health in rodents. To investigate the translational potential in humans, we evaluated the effects of dietary met...

Thomas Olsen, Bente Øvrebø, Nadia Haj-Yasein… in Journal of Translational Medicine (2020)

Article

Circulating linoleic acid and alpha-linolenic acid and glucose metabolism: the Hoorn Study

Data on the relation between linoleic acid (LA) and alpha-linolenic acid (ALA) and type 2 diabetes mellitus (T2DM) risk are scarce and inconsistent. The aim of this study was to investigate the association of ...

Mieke Cabout, Marjan Alssema, Giel Nijpels… in European Journal of Nutrition (2017)

Article

Amino acid changes during transition to a vegan diet supplemented with fish in healthy humans

To explore whether changes in dietary protein sources can lower plasma branched-chain amino acids (BCAAs), aromatic amino acids and sulfur amino acids (SAAs) that are often elevated in the obese, insulin-resi...

Amany Elshorbagy, Fredrik Jernerén, Marianne Basta… in European Journal of Nutrition (2017)