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Article
BNIP3L/NIX-mediated mitophagy alleviates passive stress-co** behaviors induced by tumor necrosis factor-α
Recent studies based on animal models of various neurological disorders have indicated that mitophagy, a selective autophagy that eliminates damaged and superfluous mitochondria through autophagic degradation,...
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Article
Gut microbiome-derived ammonia modulates stress vulnerability in the host
Ammonia has been long recognized as a metabolic waste product with well-known neurotoxic effects. However, little is known about the beneficial function of endogenous ammonia. Here, we show that gut ammonia li...
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Article
Open AccessCell type-specific NRBF2 orchestrates autophagic flux and adult hippocampal neurogenesis in chronic stress-induced depression
Dysfunctional autophagy and impairment of adult hippocampal neurogenesis (AHN) each contribute to the pathogenesis of major depressive disorder (MDD). However, whether dysfunctional autophagy is linked to aber...
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Article
N-acetylcysteine facilitates extinction of cued fear memory in rats via reestablishing basolateral amygdala glutathione homeostasis
Individual differences in the development of uncontrollable fear in response to traumatic stressors have been observed in clinic, but the underlying mechanisms remain unknown. In the present study we first con...
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Article
Open AccessPresenilin1 inhibits glioblastoma cell invasiveness via promoting Sortilin cleavage
Alzheimer’s disease (AD) and glioblastoma are the most common and devastating diseases in the neurology and neurosurgery departments, respectively. Our previous research reports that the AD-related protein Pre...
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Article
Relationships between accelerometer-measured and multiple sclerosis: a 2-sample Mendelian randomization study
Observational studies suggest that physical activity (PA) can independently modify the risk of develo** multiple sclerosis (MS).
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Article
Open AccessEffect of the transcription factor YY1 on the development of pancreatic endocrine and exocrine tumors: a narrative review
Pancreatic tumors are classified into endocrine and exocrine types, and the clinical manifestations in patients are nonspecific. Most patients, especially those with pancreatic ductal adenocarcinoma (PDAC), ha...
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Article
Open AccessTRPV4 activates the Cdc42/N-wasp pathway to promote glioblastoma invasion by altering cellular protrusions
The invasion ability of glioblastoma (GBM) causes tumor cells to infiltrate the surrounding brain parenchyma and leads to poor outcomes. Transient receptor potential vanilloid 4 (TRPV4) exhibits a remarkable r...
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Article
Open AccessS-methyl-L-cysteine Protects against Antimycin A-induced Mitochondrial Dysfunction in Neural Cells via Mimicking Endogenous Methionine-centered Redox Cycle
Mitochondrial superoxide overproduction is believed to be responsible for the neurotoxicity associated with neurodegeneration. Mitochondria-targeted antioxidants, such as MitoQ, have emerged as potentially eff...
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Article
Open AccessPresenilin1 exerts antiproliferative effects by repressing the Wnt/β-catenin pathway in glioblastoma
Glioblastoma and Alzheimer’s disease (AD) are the most common and devastating diseases in the central nervous system. The dysfunction of Presenilin1 is the main reason for AD pathogenesis. However, the molecul...
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Article
ZnO nanosheet arrays/graphene foam: voltammetric determination of dopamine in the presence of ascorbic acid and uric acid
Nickel foam (NF) was used as sacrificial template to synthesize graphene foam (GF) by chemical vapor deposition (CVD). ZnO NSAs were grown on the GF by hydrothermal synthesis to fabricate ZnO NSA/GF, which was...
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Article
Case-based reasoning model based on attribute weights optimized by genetic algorithm for predicting end temperature of molten steel in RH
Temperature control is the key of Ruhrstahl-Heraeus (RH) process in steelmaking plant. The accuracy of RH control model greatly affects the molten steel temperature fluctuation. To obtain RH control model with...
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Article
Golf ball-like MoS2 nanosheet arrays anchored onto carbon nanofibers for electrochemical detection of dopamine
Arrays of molybdenum(IV) disulfide nanosheets resembling the shape of golf balls (MoS2 NSBs) were deposited on carbon nanofibers (CNFs), which are shown to enable superior electrochemical detection of dopamine wi...
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Article
Open AccessSortilin promotes glioblastoma invasion and mesenchymal transition through GSK-3β/β-catenin/twist pathway
High aggressiveness is a hallmark of glioblastoma and predicts poor prognosis of patients with glioblastoma. The expression level of sortilin has been preliminarily reported to be elevated in high-grade glioma...
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Article
Electrochemical determination of levodopa in the presence of uric acid using ZnO nanoflowers-reduced graphene oxide
ZnO nanoflowers (ZnO NFs) were prepared by hydrothermal synthesis and graphene oxide nanosheets (GO NSs) were synthesized by the Hummer’s method. Then, ZnO NFs were dispersed in GO dispersion and sprayed onto ...
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Article
Synthesis of graphene/ZnO nanoflowers and electrochemical determination of levodopa in the presence of uric acid
ZnO nanoflowers (ZnONFs) were synthesized by a simple hydrothermal method. Then, ZnONFs suspension was sprayed onto the indium tin oxide coated glass. Finally, graphene was deposited on the surface of ZnONFs (...
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Article
Preparation of three-dimensional hollow graphene balls and simultaneous electrochemical determination of dopamine and uric acid
Nickel nanoparticles (Ni-NPs) were synthesized by the reduction reaction of NiCl2·6H2O, N2H4·H2O and NaOH, and then the graphene layers were coated on the surface of Ni-NPs by the carbide cladding method while tr...
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Article
Potentiation of Surface Stability of AMPA Receptors by Sulfhydryl Compounds: A Redox-Independent Effect by Disrupting Palmitoylation
Sulfhydryl compounds such as dithiothreitol (DTT) and β-mercaptoethanol (β-ME) are widely used as redox agents. Previous studies in our group and other laboratory have reported the effect of sulfhydryl compoun...
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Article
Open AccessMultiple intracranial and spinal metastases from a nonfunctioning pituitary adenoma following multiple surgeries: an illustrative case with 16 years of follow-up
Pituitary adenomas are the third most common primary intracranial tumor; however, those with postoperative metastases are very rare and are classically considered as pituitary carcinomas. The field of neurosur...
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Article
Comparative growth, dry matter accumulation and photosynthetic rate of seven species of Eucalypt in response to phosphorus supply
Plantations of eucalypts as short-rotation tree crops are rapidly expanding in tropical and sub-tropical regions, including southern China, where the soils are acidic and available phosphorus (P) is limited. W...
