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Article
Cadmium induces microcytosis and anisocytosis without anaemia in hypertensive rats
Dietary cadmium (Cd2+) intake is implicated in the pathogenesis of hypertension and anaemia, but there is a paucity of information on the haematological changes in hypertensive conditions. This study, therefore, ...
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Article
Open AccessPre-operative vs. post-operative stereotactic radiosurgery for operative metastatic brain tumors: study protocol for a phase III clinical trial
Almost one third of cancer patients in the United States will develop brain metastases on an annual basis. Surgical resection is indicated in the setting of brain metastases for reasons, such as maximizing loc...
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Article
Open AccessEstimating the risk of brain metastasis for patients newly diagnosed with cancer
Brain metastases (BM) affect clinical management and prognosis but limited resources exist to estimate BM risk in newly diagnosed cancer patients. Additionally, guidelines for brain MRI screening are limited. ...
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Article
Contemporary radiotherapy and radiosurgery techniques for refractory pituitary adenomas
The pituitary gland is a potential site for a range of pathologies, for which treatment can involve resection and/or ionizing radiation. Modern stereotactic radiosurgery (SRS) involves highly conformal radiati...
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Article
Initial results of a phase II trial of 18F-DOPA PET-guided re-irradiation for recurrent high-grade glioma
In-field high-grade glioma (HGG) recurrence is a common challenge with limited treatment options, including re-irradiation. The radiotracer 3,4-dihydroxy-6-[18F]-fluoro-l-phenylalanine (18F-DOPA) crosses the bloo...
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Article
Dose-escalated accelerated hypofractionation for elderly or frail patients with a newly diagnosed glioblastoma
The standard of care for elderly glioblastoma patients is 40 Gy in 15 fraction radiotherapy with temozolomide (TMZ). However, this regimen has a lower biologic equivalent dose (BED) compared to the Stupp regim...
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Article
The role of single-fraction stereotactic radiosurgery for atypical meningiomas (WHO grade II): treatment results based on a 25-year experience
To clarify the role of stereotactic radiosurgery (SRS) for atypical meningiomas (AM).
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Article
Cadmium-induced hypertension is associated with renal myosin light chain phosphatase inhibition via increased T697 phosphorylation and p44 mitogen-activated protein kinase levels
Dietary intake of the heavy metal cadmium (Cd2+) is implicated in hypertension, but potassium supplementation reportedly mitigates hypertension. This study aims to elucidate the hypertensive mechanism of Cd2+. Va...
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Article
Open AccessForm and content of Jamaican cannabis edibles
In 2017, the Jamaican government banned the sale of cannabis-infused edibles after reports of over-intoxication in adults and children. There is a general lack of public awareness regarding the risk involved w...
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Article
Long-term outcomes of grade I/II skull base chondrosarcoma: an insight into the role of surgery and upfront radiotherapy
To clarify the need for post-operative radiation treatment in skull base chondrosarcomas (SBCs).
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Article
Open AccessCurrent status and recent advances in resection cavity irradiation of brain metastases
Despite complete surgical resection brain metastases are at significant risk of local recurrence without additional radiation therapy. Traditionally, the addition of postoperative whole brain radiotherapy (WBR...
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Article
Open AccessLow dimensional nanostructures of fast ion conducting lithium nitride
As the only stable binary compound formed between an alkali metal and nitrogen, lithium nitride possesses remarkable properties and is a model material for energy applications involving the transport of lithiu...
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Article
Prescription of memantine during non-stereotactic, brain-directed radiation among patients with brain metastases: a population-based study
Whole brain radiation therapy (WBRT) remains an important component of treatment for patients with multiple brain metastases (BrM) but is associated with significant neurotoxicity and memory impairment. Althou...
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Article
Brain metastases resection cavity radio—surgery based on T2-weighted MRI: technique assessment
Stereotactic radiosurgery (SRS) is commonly performed after surgical resection of brain metastases to reduce the chance of local tumor recurrence while maintaining cognitive function. Target delineation in the...
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Article
Assembling the brain trust: the multidisciplinary imperative in neuro-oncology
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Article
Correction to: Phase I-II trial of imatinib mesylate (Gleevec; STI571) in treatment of recurrent oligodendroglioma and mixed oligoastrocytoma. North central cancer treatment group study N0272 (ALLIANCE/NCCTG)
The last author's first name was truncated in the initial online publication. The original article has been corrected.
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Article
Breast cancer subtype and intracranial recurrence patterns after brain-directed radiation for brain metastases
Brain metastases from breast cancer are frequently managed with brain-directed radiation but the impact of subtype on intracranial recurrence patterns after radiation has not been well-described. We investigat...
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Article
Phase I-II trial of imatinib mesylate (Gleevec; STI571) in treatment of recurrent oligodendroglioma and mixed oligoastrocytoma. North central cancer treatment group study N0272 (ALLIANCE/NCCTG)
To evaluate the pharmacokinetics and efficacy of imatinib in patients with recurrent oligodendroglial tumors.
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Article
Local control after brain-directed radiation in patients with cystic versus solid brain metastases
Brain metastases can be radiographically cystic or solid. Cystic metastases are associated with a greater intracranial disease burden and poorer oncologic outcomes, but the impact of cystic versus solid appear...
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Article
Open AccessThe impact of histopathology and NAB2–STAT6 fusion subtype in classification and grading of meningeal solitary fibrous tumor/hemangiopericytoma
Meningeal solitary fibrous tumor (SFT)/hemangiopericytoma (HPC) is a rare tumor with propensity for recurrence and metastasis. Although multiple classification schemes have been proposed, optimal risk stratifi...
