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Article
Open AccessInfluence of drug transporters and stereoselectivity on the brain penetration of pioglitazone as a potential medicine against Alzheimer's disease
Pioglitazone is currently undergoing clinical trials for treatment of Alzheimer's disease (AD). However, poor brain penetration remains an obstacle to development of the drug for such intended clinical uses. I...
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Article
In vivo photodynamic therapy using upconversion nanoparticles as remote-controlled nanotransducers
A limitation of photodynamic therapy (PDT) is the depth of penetration of visible light needed for activation of the photosensitizers, restricting treatment to tumors on or just under the skin’s surface or tho...
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Article
Ursolic acid inhibits multiple cell survival pathways leading to suppression of growth of prostate cancer xenograft in nude mice
Activation of transcription factors nuclear factor-κB (NF-κB) and signal transducer and activator of transcription 3 (STAT3) is frequently observed in prostate cancer and has been linked with tumor cell prolif...
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Article
Nanoparticulate Delivery System Targeted to Tumor Neovasculature for Combined Anticancer and Antiangiogenesis Therapy
Herein, we designed a nanoparticulate combined delivery system decorated on the surface with RGD peptide, and encapsulating paclitaxel (PTX) and combretastatin A4 (CA4) as the respective anticancer and antiang...
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Article
LC Determination of trans-3,5,3′,4′,5′-Pentamethoxystilbene in Rat Plasma
A simple LC method has been developed and validated to determine trans-3,5,3′,4′,5′-pentamethoxystilbene (PMS) in rat plasma. Chromatographic separation was achieved through gradient delivery of acetonitrile and ...
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Article
Metabolic footprinting of tumorigenic and nontumorigenic uroepithelial cells using two-dimensional gas chromatography time-of-flight mass spectrometry
In this study, gas chromatography mass spectrometry (GC-MS) and two-dimensional gas chromatography time-of-flight mass spectrometry (GC×GC-TOFMS) were employed for the metabolic footprinting of a pair of immor...
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Article
Interaction of Oxazaphosphorines with Multidrug Resistance-Associated Protein 4 (MRP4)
Multidrug resistance-associated protein 4 (MRP4) is an organic anion efflux pump capable of transporting nucleoside, nucleotide analogs, and cyclic nucleotide. MRP4 could have an influence on the resistance an...
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Article
Formulation and Optimization of Zinc-Pectinate Beads for the Controlled Delivery of Resveratrol
Preventive and therapeutic efficacies of resveratrol on several lower gastrointestinal (GI) diseases (e.g., colorectal cancer, colitis) are well documented. To overcome the problems due to its rapid absorption...
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Article
Comparing the Relative Oxidative DNA Damage Caused by Various Arsenic Species by Quantifying Urinary Levels of 8-Hydroxy-2′-Deoxyguanosine with Isotope-Dilution Liquid Chromatography/Mass Spectrometry
To investigate the association between various arsenicals and the potential oxidative stress caused, we examined the urinary levels of 8-hydroxy-2′-deoxyguanosine (8-OH-dGuo), a biomarker of oxidative DNA dama...
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Article
Design of a Multifunctional PLGA Nanoparticulate Drug Delivery System: Evaluation of its Physicochemical Properties and Anticancer Activity to Malignant Cancer Cells
Several individual approaches were combined to fabricate a novel nanoparticulate drug delivery system to achieve targeting and anticancer effects in various malignant cancer cells.
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Article
The Impact of Aqueous Solubility and Dose on the Pharmacokinetic Profiles of Resveratrol
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Article
The Impact of Aqueous Solubility and Dose on the Pharmacokinetic Profiles of Resveratrol
This study aimed at the investigation of the impact of aqueous solubility and dose manipulation on the pharmacokinetics of resveratrol.
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Article
Spontaneous slow flow in the saphenous vein graft: a relevant distinction of macrovascular endothelial dysfunction
Spontaneous slow flow without significant obstructive stenosis, as encountered during diagnostic angiography, has mostly been reported in native coronary arteries. This phenomenon has been associated with angi...
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Article
Arsenic compounds induce cytotoxicity and apoptosis in cisplatin-sensitive and -resistant gynecological cancer cell lines
Purpose: Arsenic compounds have been found to be effective in the treatment of acute promyelocytic leukemia through the downregulation of bcl-2 expression. Resistant ovarian cancer cells often overexpress bcl-2 ...
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Article
Stress reduction by geometric compliance matching at vascular graft anastomoses
An analysis is presented of stresses developed with different junctional configurations of end-to-end vascular graft anastomoses with severe compliance mismatch. Junctions of circular transverse sections and j...
