10 Result(s)
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Peramaiyan Rajendran
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Article
Open AccessAnti-metastasis activity of 5,4’-dihydroxy 6,8-dimethoxy 7-O-rhamnosyl flavone from Indigofera aspalathoides Vahl on breast cancer cells
Breast cancer presents a significant challenge due to its high rates of illness and mortality, necessitating more effective treatment approaches. While traditional treatments offer some benefits, they often la...
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Article
Open AccessThe effect of COVID-19 on nuclear medicine and radiopharmacy activities: A global survey
Globally, COVID-19 affected radiopharmaceutical laboratories. This study sought to determine the economic, service, and research impacts of COVID-19 on radiopharmacy. This online survey was conducted with the ...
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Reference Work Entry In depth
Benzo(a)Pyrene-Induced ROS-Mediated Lung Cancer
Lung cancer is the world’s second-largest cause of death from cancer. Cigarette smoking is identified as one of the single, well-known risk factors for lung cancer of all types. A potent carcinogen in cigarett...
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Living Reference Work Entry In depth
Benzo(a)Pyrene Induced ROS-Mediated Lung Cancer
Lung cancer is the world’s second-largest cause of death from cancer. Cigarette smoking is identified as one of the single, well-known risk factors for lung cancer of all types. A potent carcinogen in cigarett...
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Article
d-pinitol mitigates tumor growth by modulating interleukins and hormones and induces apoptosis in rat breast carcinogenesis through inhibition of NF-κB
Breast cancer is the most prevalent malignant neoplasm in the world, and chemoprevention through dietary intervention strategy is an emerging option to reduce the incidence. d-pinitol (DP), a major component of s...
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Article
Open AccessInhibition of STAT3 dimerization and acetylation by garcinol suppresses the growth of human hepatocellular carcinoma in vitro and in vivo
Constitutive activation of signal transducer and activator of transcription 3 (STAT3) has been linked with proliferation, survival, invasion and angiogenesis of a variety of human cancer cells, including hepat...
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Article
An anthraquinone derivative, emodin sensitizes hepatocellular carcinoma cells to TRAIL induced apoptosis through the induction of death receptors and downregulation of cell survival proteins
Recombinant tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is currently under clinical trials for cancer, however many tumor cells, including hepatocellular carcinoma (HCC) develop resistance ...
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Article
Celastrol inhibits tumor cell proliferation and promotes apoptosis through the activation of c-Jun N-terminal kinase and suppression of PI3 K/Akt signaling pathways
Celastrol, a plant triterpene has attracted great interest recently, especially for its potential anti-inflammatory and anti-cancer activities. In the present report, we investigated the effect of celastrol on...
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Article
Open AccessPlumbagin inhibits invasion and migration of breast and gastric cancer cells by downregulating the expression of chemokine receptor CXCR4
Increasing evidence indicates that the interaction between the CXC chemokine receptor-4 (CXCR4) and its ligand CXCL12 is critical in the process of metastasis that accounts for more than 90% of cancer-related ...
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Article
Ursolic acid inhibits multiple cell survival pathways leading to suppression of growth of prostate cancer xenograft in nude mice
Activation of transcription factors nuclear factor-κB (NF-κB) and signal transducer and activator of transcription 3 (STAT3) is frequently observed in prostate cancer and has been linked with tumor cell prolif...
