18 Result(s)

Article

Connectome dysfunction in patients at clinical high risk for psychosis and modulation by oxytocin

Abnormalities in functional brain networks (functional connectome) are increasingly implicated in people at Clinical High Risk for Psychosis (CHR-P). Intranasal oxytocin, a potential novel treatment for the CH...

Cathy Davies, Daniel Martins, Ottavia Dipasquale… in Molecular Psychiatry (2024)

Article

Neuroanatomical heterogeneity and homogeneity in individuals at clinical high risk for psychosis

Individuals at Clinical High Risk for Psychosis (CHR-P) demonstrate heterogeneity in clinical profiles and outcome features. However, the extent of neuroanatomical heterogeneity in the CHR-P state is largely u...

Helen Baldwin, Joaquim Radua, Mathilde Antoniades… in Translational Psychiatry (2022)

Article

Cortical and subcortical neuroanatomical signatures of schizotypy in 3004 individuals assessed in a worldwide ENIGMA study

Neuroanatomical abnormalities have been reported along a continuum from at-risk stages, including high schizotypy, to early and chronic psychosis. However, a comprehensive neuroanatomical map** of schizotypy...

Matthias Kirschner, Benazir Hodzic-Santor, Mathilde Antoniades… in Molecular Psychiatry (2022)

Article

Correction: Adverse clinical outcomes in people at clinical high-risk for psychosis related to altered interactions between hippocampal activity and glutamatergic function

Paul Allen, Emily J. Hird, Natasza Orlov, Gemma Modinos… in Translational Psychiatry (2021)

Article

Adverse clinical outcomes in people at clinical high-risk for psychosis related to altered interactions between hippocampal activity and glutamatergic function

Preclinical rodent models suggest that psychosis involves alterations in the activity and glutamatergic function in the hippocampus, driving dopamine activity through projections to the striatum. The extent to...

Paul Allen, Emily J. Hird, Natasza Orlov, Gemma Modinos… in Translational Psychiatry (2021)

Article

Interactions between hippocampal activity and striatal dopamine in people at clinical high risk for psychosis: relationship to adverse outcomes

Preclinical models propose that increased hippocampal activity drives subcortical dopaminergic dysfunction and leads to psychosis-like symptoms and behaviors. Here, we used multimodal neuroimaging to examine t...

Gemma Modinos, Anja Richter, Alice Egerton, Ilaria Bonoldi… in Neuropsychopharmacology (2021)

Article

A single dose of cannabidiol modulates medial temporal and striatal function during fear processing in people at clinical high risk for psychosis

Emotional dysregulation and anxiety are common in people at clinical high risk for psychosis (CHR) and are associated with altered neural responses to emotional stimuli in the striatum and medial temporal lobe...

Cathy Davies, Robin Wilson, Elizabeth Appiah-Kusi… in Translational Psychiatry (2020)

Article

Acute oxytocin effects in inferring others’ beliefs and social emotions in people at clinical high risk for psychosis

Social deficits are key hallmarks of the Clinical High Risk for Psychosis (CHR-P) state and of established psychotic disorders, and contribute to impaired social functioning, indicating a potential target for ...

André Schmidt, Cathy Davies, Yannis Paloyelis, Nicholas Meyer… in Translational Psychiatry (2020)

Article

Glutamatergic and dopaminergic function and the relationship to outcome in people at clinical high risk of psychosis: a multi-modal PET-magnetic resonance brain imaging study

Preclinical models of psychosis propose that hippocampal glutamatergic neuron hyperactivity drives increased striatal dopaminergic activity, which underlies the development of psychotic symptoms. The aim of th...

Oliver D. Howes, Ilaria Bonoldi, Robert A. McCutcheon… in Neuropsychopharmacology (2020)

Article

Cannabidiol attenuates insular dysfunction during motivational salience processing in subjects at clinical high risk for psychosis

Accumulating evidence points towards the antipsychotic potential of cannabidiol. However, the neurocognitive mechanisms underlying the antipsychotic effect of cannabidiol remain unclear. We investigated this i...

Robin Wilson, Matthijs G. Bossong, Elizabeth Appiah-Kusi… in Translational Psychiatry (2019)

Article

Oxytocin modulates hippocampal perfusion in people at clinical high risk for psychosis

Preclinical and human studies suggest that hippocampal dysfunction is a key factor in the onset of psychosis. People at Clinical High Risk for psychosis (CHR-P) present with a clinical syndrome that can includ...

Cathy Davies, Yannis Paloyelis, Grazia Rutigliano… in Neuropsychopharmacology (2019)

Article

Correction: Prefrontal GABA levels, hippocampal resting perfusion and the risk of psychosis

This article was originally published under NPG’s License to Publish, but has now been made available under a [CC BY 4.0] license. The PDF and HTML versions of the paper have been modified accordingly.

Gemma Modinos, Fatma Şimşek, Matilda Azis, Matthijs Bossong… in Neuropsychopharmacology (2018)

Article

Prefrontal GABA levels, hippocampal resting perfusion and the risk of psychosis

Preclinical models propose that the onset of psychosis is associated with hippocampal hyperactivity, thought to be driven by cortical GABAergic interneuron dysfunction and disinhibition of pyramidal neurons. R...

Gemma Modinos, Fatma Şimşek, Matilda Azis, Matthijs Bossong… in Neuropsychopharmacology (2018)

Article

Real-time fMRI neurofeedback to down-regulate superior temporal gyrus activity in patients with schizophrenia and auditory hallucinations: a proof-of-concept study

Neurocognitive models and previous neuroimaging work posit that auditory verbal hallucinations (AVH) arise due to increased activity in speech-sensitive regions of the left posterior superior temporal gyrus (S...

Natasza D. Orlov, Vincent Giampietro, Owen O’Daly… in Translational Psychiatry (2018)

Article

Relationship Between Brain Glutamate Levels and Clinical Outcome in Individuals at Ultra High Risk of Psychosis

Alterations in brain glutamate levels may be associated with psychosis risk, but the relationship to clinical outcome in at-risk individuals is unknown. Glutamate concentration was measured in the left thalamu...

Alice Egerton, James M Stone, Christopher A Chaddock… in Neuropsychopharmacology (2014)

Article

Erratum: Modulation of Auditory and Visual Processing by Delta-9-Tetrahydrocannabinol and Cannabidiol: an fMRI Study

Correction to: Neuropsychopharmacology (2011) 36, 1340–1348; doi:10.1038/npp.2011.17; published online 16 March 2011 In this article, the third author's name was spelled incorrectly; the correct spelling is Sa...

Toby T Winton-Brown, Paul Allen, Sagnik Bhattacharrya… in Neuropsychopharmacology (2011)

Article

Modulation of Auditory and Visual Processing by Delta-9-Tetrahydrocannabinol and Cannabidiol: an fMRI Study

Although the effects of cannabis on perception are well documented, little is known about their neural basis or how these may contribute to the formation of psychotic symptoms. We used functional magnetic reso...

Toby T Winton-Brown, Paul Allen, Sagnik Bhattacharrya… in Neuropsychopharmacology (2011)

Article

Opposite Effects of Δ-9-Tetrahydrocannabinol and Cannabidiol on Human Brain Function and Psychopathology

Δ-9-tetrahydrocannabinol (Δ-9-THC) and Cannabidiol (CBD), the two main ingredients of the Cannabis sativa plant have distinct symptomatic and behavioral effects. We used functional magnetic resonance imaging (fMR...

Sagnik Bhattacharyya, Paul D Morrison, Paolo Fusar-Poli… in Neuropsychopharmacology (2010)