41 Result(s)

Article

Connectome dysfunction in patients at clinical high risk for psychosis and modulation by oxytocin

Abnormalities in functional brain networks (functional connectome) are increasingly implicated in people at Clinical High Risk for Psychosis (CHR-P). Intranasal oxytocin, a potential novel treatment for the CH...

Cathy Davies, Daniel Martins, Ottavia Dipasquale… in Molecular Psychiatry (2024)

Article

High levels of childhood trauma associated with changes in hippocampal functional activity and connectivity in young adults during novelty salience

Childhood trauma (CT) has been linked to increased risk for psychosis. Moreover, CT has been linked to psychosis phenotypes such as impaired cognitive and sensory functions involved in the detection of novel s...

Mélodie Derome, Sandra Machon, Holly Barker… in European Archives of Psychiatry and Clinic… (2023)

Article

Specific Pandemic-Related Worries Predict Higher Attention-Related Errors and Negative Affect Independent of Trait Anxiety in UK-Based Students

The COVID-19 pandemic has resulted in many individuals experiencing increased symptoms of anxiety. We predict that this increase may be underpinned by pandemic-related worry (PRW), characterised by repetitive ...

Chris R. H. Brown, Ya-Chun Feng, Vlad Costin… in Cognitive Therapy and Research (2023)

Article

Neuroanatomical heterogeneity and homogeneity in individuals at clinical high risk for psychosis

Individuals at Clinical High Risk for Psychosis (CHR-P) demonstrate heterogeneity in clinical profiles and outcome features. However, the extent of neuroanatomical heterogeneity in the CHR-P state is largely u...

Helen Baldwin, Joaquim Radua, Mathilde Antoniades… in Translational Psychiatry (2022)

Article

Altered relationship between cortisol response to social stress and mediotemporal function during fear processing in people at clinical high risk for psychosis: a preliminary report

Evidence suggests that people at Clinical High Risk for Psychosis (CHR) have a blunted cortisol response to stress and altered mediotemporal activation during fear processing, which may be neuroendocrine–neuro...

Cathy Davies, Elizabeth Appiah-Kusi… in European Archives of Psychiatry and Clinic… (2022)

Article

Cortical and subcortical neuroanatomical signatures of schizotypy in 3004 individuals assessed in a worldwide ENIGMA study

Neuroanatomical abnormalities have been reported along a continuum from at-risk stages, including high schizotypy, to early and chronic psychosis. However, a comprehensive neuroanatomical map** of schizotypy...

Matthias Kirschner, Benazir Hodzic-Santor, Mathilde Antoniades… in Molecular Psychiatry (2022)

Article

Correction: Adverse clinical outcomes in people at clinical high-risk for psychosis related to altered interactions between hippocampal activity and glutamatergic function

Paul Allen, Emily J. Hird, Natasza Orlov, Gemma Modinos… in Translational Psychiatry (2021)

Article

Adverse clinical outcomes in people at clinical high-risk for psychosis related to altered interactions between hippocampal activity and glutamatergic function

Preclinical rodent models suggest that psychosis involves alterations in the activity and glutamatergic function in the hippocampus, driving dopamine activity through projections to the striatum. The extent to...

Paul Allen, Emily J. Hird, Natasza Orlov, Gemma Modinos… in Translational Psychiatry (2021)

Article

Reduced cortical GABA and glutamate in high schizotypy

Abnormal functioning of the inhibitory gamma-aminobutyric acid (GABA) and excitatory (glutamate) systems is proposed to play a role in the development of schizophrenia spectrum disorder. Although results are m...

Petya Kozhuharova, Andreea O. Diaconescu, Paul Allen in Psychopharmacology (2021)

Article

Interactions between hippocampal activity and striatal dopamine in people at clinical high risk for psychosis: relationship to adverse outcomes

Preclinical models propose that increased hippocampal activity drives subcortical dopaminergic dysfunction and leads to psychosis-like symptoms and behaviors. Here, we used multimodal neuroimaging to examine t...

Gemma Modinos, Anja Richter, Alice Egerton, Ilaria Bonoldi… in Neuropsychopharmacology (2021)

Article

A single dose of cannabidiol modulates medial temporal and striatal function during fear processing in people at clinical high risk for psychosis

Emotional dysregulation and anxiety are common in people at clinical high risk for psychosis (CHR) and are associated with altered neural responses to emotional stimuli in the striatum and medial temporal lobe...

Cathy Davies, Robin Wilson, Elizabeth Appiah-Kusi… in Translational Psychiatry (2020)

Article

Acute oxytocin effects in inferring others’ beliefs and social emotions in people at clinical high risk for psychosis

Social deficits are key hallmarks of the Clinical High Risk for Psychosis (CHR-P) state and of established psychotic disorders, and contribute to impaired social functioning, indicating a potential target for ...

André Schmidt, Cathy Davies, Yannis Paloyelis, Nicholas Meyer… in Translational Psychiatry (2020)

Article

Glutamatergic and dopaminergic function and the relationship to outcome in people at clinical high risk of psychosis: a multi-modal PET-magnetic resonance brain imaging study

Preclinical models of psychosis propose that hippocampal glutamatergic neuron hyperactivity drives increased striatal dopaminergic activity, which underlies the development of psychotic symptoms. The aim of th...

Oliver D. Howes, Ilaria Bonoldi, Robert A. McCutcheon… in Neuropsychopharmacology (2020)

Article

Cannabidiol attenuates insular dysfunction during motivational salience processing in subjects at clinical high risk for psychosis

Accumulating evidence points towards the antipsychotic potential of cannabidiol. However, the neurocognitive mechanisms underlying the antipsychotic effect of cannabidiol remain unclear. We investigated this i...

Robin Wilson, Matthijs G. Bossong, Elizabeth Appiah-Kusi… in Translational Psychiatry (2019)

Article

Oxytocin modulates hippocampal perfusion in people at clinical high risk for psychosis

Preclinical and human studies suggest that hippocampal dysfunction is a key factor in the onset of psychosis. People at Clinical High Risk for psychosis (CHR-P) present with a clinical syndrome that can includ...

Cathy Davies, Yannis Paloyelis, Grazia Rutigliano… in Neuropsychopharmacology (2019)