23 Result(s)
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Robert A. McCutcheon
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Article
Open AccessRisk factors for PTSD symptoms following PICU admission for childhood septic shock
Objective
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Open AccessConnectome dysfunction in patients at clinical high risk for psychosis and modulation by oxytocin
Abnormalities in functional brain networks (functional connectome) are increasingly implicated in people at Clinical High Risk for Psychosis (CHR-P). Intranasal oxytocin, a potential novel treatment for the CH...
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Open AccessThe magnitude and variability of neurocognitive performance in first-episode psychosis: a systematic review and meta-analysis of longitudinal studies
Neurocognitive deficits are a core feature of psychotic disorders, but it is unclear whether they affect all individuals uniformly. The aim of this systematic review and meta-analysis was to synthesize the evi...
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Open AccessA leaky umbrella has little value: evidence clearly indicates the serotonin system is implicated in depression
A recent “umbrella” review examined various biomarkers relating to the serotonin system, and concluded there was no consistent evidence implicating serotonin in the pathophysiology of depression. We present re...
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Open AccessThe relationship between striatal dopamine and anterior cingulate glutamate in first episode psychosis changes with antipsychotic treatment
The neuromodulator dopamine and excitatory neurotransmitter glutamate have both been implicated in the pathogenesis of psychosis, and dopamine antagonists remain the predominant treatment for psychotic disorde...
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Open AccessLongitudinal change in neurocognitive functioning in children and adolescents at clinical high risk for psychosis: a systematic review
Clinical high risk of psychosis (CHR-P) population has become an attractive area of interest in preventing transitions to psychosis. The consequences of develo** a psychotic disorder may be worse in cases of...
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Open AccessCorrection: Cognitive impairment in schizophrenia: aetiology, pathophysiology, and treatment
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Correction: Striatal dopaminergic alterations in individuals with copy number variants at the 22q11.2 genetic locus and their implications for psychosis risk: a [18F]-DOPA PET study
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Open AccessVariability and magnitude of brain glutamate levels in schizophrenia: a meta and mega-analysis
Glutamatergic dysfunction is implicated in schizophrenia pathoaetiology, but this may vary in extent between patients. It is unclear whether inter-individual variability in glutamate is greater in schizophreni...
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Open AccessCognitive impairment in schizophrenia: aetiology, pathophysiology, and treatment
Cognitive deficits are a core feature of schizophrenia, account for much of the impaired functioning associated with the disorder and are not responsive to existing treatments. In this review, we first describ...
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Open AccessStriatal dopaminergic alterations in individuals with copy number variants at the 22q11.2 genetic locus and their implications for psychosis risk: a [18F]-DOPA PET study
Dopaminergic dysregulation is one of the leading hypotheses for the pathoetiology underlying psychotic disorders such as schizophrenia. Molecular imaging studies have shown increased striatal dopamine synthesi...
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A systematic review and meta-analysis of brain volume abnormalities in disruptive behaviour disorders, antisocial personality disorder and psychopathy
Individuals with disruptive behaviour disorders in youth and antisocial personality disorder and psychopathy as adults share some clinical characteristics, but also diverge in important ways. Existing meta-ana...
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Shared and separate patterns in brain morphometry across transdiagnostic dimensions
Determining similarities and differences in brain structure across psychiatric disorders is important to determine if psychiatric taxonomy is reflected in distinct brain structural changes. As previous neuroim...
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Open AccessThe relationship between glutamate, dopamine, and cortical gray matter: A simultaneous PET-MR study
Prefrontal cortex has been shown to regulate striatal dopaminergic function via glutamatergic mechanisms in preclinical studies. Concurrent disruption of these systems is also often seen in neuropsychiatric di...
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Open AccessN-methyl-D-aspartate receptor availability in first-episode psychosis: a PET-MR brain imaging study
N-methyl-D-aspartate receptor (NMDAR) hypofunction is hypothesised to underlie psychosis but this has not been tested early in illness. To address this, we studied 40 volunteers (21 patients with first-episode...
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Open AccessGlutamate connectivity associations converge upon the salience network in schizophrenia and healthy controls
Alterations in cortical inter-areal functional connectivity, and aberrant glutamatergic signalling are implicated in the pathophysiology of schizophrenia but the relationship between the two is unclear. We use...
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The efficacy and heterogeneity of antipsychotic response in schizophrenia: A meta-analysis
The response to antipsychotic treatment in schizophrenia appears to vary, and as such it has been proposed that different subtypes of schizophrenia exist, defined by treatment-response. This has not been forma...
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Open AccessMagnitude and heterogeneity of brain structural abnormalities in 22q11.2 deletion syndrome: a meta-analysis
The 22q11.2 deletion syndrome (22q11.2DS) is a neurodevelopmental disorder associated with a number of volumetric brain abnormalities. The syndrome is also associated with an increased risk for neuropsychiatri...
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Open AccessGlutamatergic and dopaminergic function and the relationship to outcome in people at clinical high risk of psychosis: a multi-modal PET-magnetic resonance brain imaging study
Preclinical models of psychosis propose that hippocampal glutamatergic neuron hyperactivity drives increased striatal dopaminergic activity, which underlies the development of psychotic symptoms. The aim of th...
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Open AccessHeterogeneity and efficacy of antipsychotic treatment for schizophrenia with or without treatment resistance: a meta-analysis
Two important clinical questions are whether there is a subtype of schizophrenia which responds differently to clozapine relative to other antipsychotics, and whether greater efficacy of clozapine is dependent...
