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Article
Open AccessThe clinical impact of estimating low-density lipoprotein cholesterol (LDL-C) using different equations in the general population
Low-density lipoprotein cholesterol (LDL-C) is associated with atherosclerotic cardiovascular disease (ASCVD). Friedewald, Sampson, and Martin-Hopkins equations are used to calculate LDL-C. This study compares...
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Article
Open AccessWhite blood cells and chronic rhinosinusitis: a Mendelian randomization study
Risk factors for the pathogenesis of chronic rhinosinusitis (CRS) remain largely undetermined, which is likely due to the heterogeneity of the disease. White blood cell counts have been largely unexplored as a...
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Article
Open AccessAssociation between CYP metabolizer phenotypes and selective serotonin reuptake inhibitors induced weight gain: a retrospective cohort study
Prescription medications such as selective serotonin reuptake inhibitors (SSRIs), commonly used to treat depression, are associated with weight gain. The role of pharmacogenomics in predicting SSRI-induced wei...
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Article
Pediatric brain tumor cell lines exhibit miRNA-depleted, Y RNA-enriched extracellular vesicles
Medulloblastoma (MB) and diffuse infiltrative pontine glioma (DIPG) are malignant pediatric tumors. Extracellular vesicles (EVs) and their bioactive cargoes have been implicated in tumorigenesis. Most studies ...
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Article
Open AccessAdhesion pathway proteins and risk of atrial fibrillation in the Multi-Ethnic Study of Atherosclerosis
The cellular adhesion pathway has been suggested as playing an important role in the pathogenesis of atrial fibrillation (AF). However, prior studies that have investigated the role of adhesion pathway protein...
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Article
Open Access8q24 clear cell renal cell carcinoma germline variant is associated with VHL mutation status and clinical aggressiveness
The four most commonly-mutated genes in clear cell renal cell carcinoma (ccRCC) tumors are BAP1, PBRM1, SETD2 and VHL. And, there are currently 14 known RCC germline variants that have been reproducibly shown to ...
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Article
Rheumatoid pulmonary nodules: clinical and imaging features compared with malignancy
The objective of this study was to identify clinical and imaging features that distinguish rheumatoid lung nodules from malignancy.
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Article
Adult infiltrating gliomas with WHO 2016 integrated diagnosis: additional prognostic roles of ATRX and TERT
The “integrated diagnosis” for infiltrating gliomas in the 2016 revised World Health Organization (WHO) classification of tumors of the central nervous system requires assessment of the tumor for IDH mutations an...
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Article
Genome-wide association study of glioma subtypes identifies specific differences in genetic susceptibility to glioblastoma and non-glioblastoma tumors
Beatrice Melin, Richard Houlston, Melissa Bondy and colleagues report results of a large-scale genome-wide association study of glioma. They identify five new risk loci for glioblastoma and eight new risk loci...
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Article
Improvement in Cardiovascular Risk Prediction with Electronic Health Records
The aim of this study was to compare the QRISKII, an electronic health data-based risk score, to the Framingham Risk Score (FRS) and atherosclerotic cardiovascular disease (ASCVD) score. Risk estimates were ca...
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Article
Blood group antigen loci demonstrate multivariate genetic associations with circulating cellular adhesion protein levels in the Multi-Ethnic Study of Atherosclerosis
The cellular adhesion pathway is critical in the pathophysiology of atherosclerosis, and genetic factors contributing to regulation of circulating levels of related proteins may be relevant to risk prediction ...
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Article
A Robust e-Epidemiology Tool in Phenoty** Heart Failure with Differentiation for Preserved and Reduced Ejection Fraction: the Electronic Medical Records and Genomics (eMERGE) Network
Identifying populations of heart failure (HF) patients is paramount to research efforts aimed at develo** strategies to effectively reduce the burden of this disease. The use of electronic medical record (EM...
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Article
Open AccessPrognostic significance of multiple kallikreins in high-grade astrocytoma
Kallikreins have clinical value as prognostic markers in a subset of malignancies examined to date, including kallikrein 3 (prostate specific antigen) in prostate cancer. We previously demonstrated that kallik...
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Article
Multi-ethnic analysis reveals soluble l-selectin may be post-transcriptionally regulated by 3′UTR polymorphism: the Multi-Ethnic Study of Atherosclerosis (MESA)
l-Selectin is constitutively expressed on leukocytes and mediates their interaction with endothelial cells during inflammation. Previous studies on the association of soluble l-selectin (sl-selec...
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Article
The impact of concurrent temozolomide with adjuvant radiation and IDH mutation status among patients with anaplastic astrocytoma
This study assesses the controversial role of temozolomide (TMZ) concurrent with adjuvant radiation (RT) in patients with anaplastic astrocytoma (AA). The impact of isocitrate dehydrogenase (IDH) status on the...
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Article
Variants near TERT and TERC influencing telomere length are associated with high-grade glioma risk
Kyle Walsh and colleagues identify a variant near TERC associated with glioma susceptibility. They further show that glioma risk alleles near TERC and TERT are associated with longer mean telomere length in leuko...
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Article
Open AccessReceptivity and preferences of pancreatic cancer family members for participating in lifestyle programs to reduce cancer risk
Cancer is a shared family experience that might provide an opportunity for lifestyle change among at-risk family members. The purpose of this study was to assess receptivity and preferences for cancer risk red...
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Article
A low-frequency variant at 8q24.21 is strongly associated with risk of oligodendroglial tumors and astrocytomas with IDH1 or IDH2 mutation
Robert Jenkins and colleagues report fine map** of the glioma risk region at 8q24.21. They identify a new low-frequency variant in the region that is strongly associated with risk of oligodendroglial tumors ...
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Article
Therapeutic doses of cranial irradiation induce hippocampus-dependent cognitive deficits in young mice
Fractionated cranial irradiation is an essential part of treatment in the management of cohorts of pediatric brain tumor and leukemia patients. Ionizing radiation damages normal brain parenchyma through a vari...
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Article
A germline variant in the TP53 polyadenylation signal confers cancer susceptibility
Simon Stacey, Kari Stefansson and colleagues show that a germline variant in the TP53 polyadenylation signal is associated with increased risk of basal cell carcinoma and other solid tumors.
