4 Result(s)

Article

NIMBus: a negative binomial regression based Integrative Method for mutation Burden Analysis

Identifying frequently mutated regions is a key approach to discover DNA elements influencing cancer progression. However, it is challenging to identify these burdened regions due to mutation rate heterogeneit...

**g Zhang, Jason Liu, Patrick McGillivray, Caroline Yi… in BMC Bioinformatics (2020)

Article

An integrative ENCODE resource for cancer genomics

ENCODE comprises thousands of functional genomics datasets, and the encyclopedia covers hundreds of cell types, providing a universal annotation for genome interpretation. However, for particular applications,...

**g Zhang, Donghoon Lee, Vineet Dhiman, Peng Jiang, Jie Xu… in Nature Communications (2020)

Article

Using ALoFT to determine the impact of putative loss-of-function variants in protein-coding genes

Variants predicted to result in the loss of function of human genes have attracted interest because of their clinical impact and surprising prevalence in healthy individuals. Here, we present ALoFT (annotation...

Suganthi Balasubramanian, Yao Fu, Mayur Pawashe… in Nature Communications (2017)

Article

Parallel coding of first and second order stimulus attributes

Patrick McGillivray, Katrin Vonderschen, Eric S Fortune… in BMC Neuroscience (2012)