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Article
Natural killer cells in first-episode psychosis: an innate immune signature?
Accumulating evidence majorly implicates immune dysfunction in the etiology of psychotic disorders. In particular, altered numbers and functions of natural killer (NK) cells have been described in psychosis, b...
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Article
Open AccessHIV therapeutic vaccine enhances non-exhausted CD4+ T cells in a randomised phase 2 trial
VAC-3S is a therapeutic vaccine comprising a highly conserved HIV-gp41 motif coupled with the CRM197 carrier protein. High levels of anti-3S antibodies (Abs) have been associated with improved protection of CD4+ ...
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Article
Open AccessPersistence of dysfunctional natural killer cells in adults with high-functioning autism spectrum disorders: stigma/consequence of unresolved early infectious events?
Autism spectrum disorders (ASD) are characterized by abnormal neurodevelopment, genetic, and environmental risk factors, as well as immune dysfunctions. Several lines of evidence suggest alterations in innate ...
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Article
B-Cell and T-Cell Phenotypes in CVID Patients Correlate with the Clinical Phenotype of the Disease
Common variable immunodeficiency (CVID) is a heterogeneous disorder characterized by recurrent infections and defective immunoglobulin production.
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Article
A natural CCL5/RANTES variant antagonist for CCR1 and CCR3
The N-terminal domain of the chemokine CCL5/regulated upon activation normal T cell expressed and secreted (RANTES) has been shown to be critical for its biological activity on leukocytes. Several N-terminus-m...
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Article
Therapeutic vaccines against HIV need international partnerships
The successes of anti-retroviral treatments against HIV are limited today by the cost and toxicity of lifelong administration. An innovative therapeutic strategy has been proposed to boost the immune system of...
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Article
Critical Role of Nitric Oxide During the Apoptosis of Peripheral Blood Leukocytes from Patients with AIDS
Highly active antiretroviral therapies (HAART) increase the CD4+ cell count, but complete normalization of this parameter has not been obtained in some patients. As oxidative stress plays an important role during...
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Article
Defective humoral responses and extensive intravascular apoptosis are associated with fatal outcome in Ebola virus-infected patients
Ebola virus is very pathogenic in humans. It induces an acute hemorrhagic fever that leads to death in about 70% of patients1. We compared the immune responses of patients who died from Ebola virus disease with t...
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Article
Distribution of the CCR5 gene 32 base pair deletion and SDF1–3'A variant in healthy individuals from different populations
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Article
Perturbation of CD4+ and CD8+ T-cell repertoires during progression to AIDS and regulation of the CD4+ repertoire during antiviral therapy
The T-cell antigen receptor (TCR) repertoire was studied longitudinally by analyzing the varying lengths of the beta chain CDR3 hypervariable region during the course of HIV-1 infection and following combinati...
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Article
Inducible Nitric Oxide Synthase and Proinflammatory Cytokine Expression by Human Keratinocytes during Acute Urticaria
IgE/allergen-dependent activation of skin mast cells is involved in acute urticaria and leads to their EL-4 release. Previously we have demonstrated in vitro the induction of the low-affinity receptor for IgE ...
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Article
Allelic repertoire of the human MICB gene
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Article
AIDS virus-specific cytotoxic T lymphocytes in lung disorders
Human immunodeficiency virus (HIV) is implicated in the development of AIDS (acquired immune deficiency syndrome)1,2. HIV infection leads to the generation of HIV-specific thymus-derived (T) lymphocytes in human...
