-
Article
Open AccessWhat is the origin of pancreatic adenocarcinoma?
The concept of pancreatic cancer origin is controversial. Acinar, ductal or islet cells have been hypothesized as the cell of origin. The pros and cons of each of these hypotheses are discussed. Based on the w...
-
Article
ErbB2 oncogene expression supports the acute pancreatitis–chronic pancreatitis sequence
The pathogenesis of chronic pancreatitis remains controversial. According to the general opinion, chronic pancreatitis is a de novo disease with a silent but progressive restructure of the pancreas in respons...
-
Article
Alteration of the langerhans islets in pancreatic cancer patients
An abnormal glucose metabolism occurs in up to 80% of pancreatic cancer patients shortly or a few months before the first clinical admission. Reasons for this abnormality are obscure. We investigated immunohis...
-
Article
One thousand faces of langerhans islets
Studies with different strains of Syrian hamsters and Syrian golden hamsters have revealed the remarkable potential of islet cells to undergo orthotopic and heterotopic metaplasia. The most common spontaneous ...
-
Article
The link between exocrine pancreatic cancer and the endocrine pancreas
Background. The histogenesis of pancreatic cancer is still debatable. Ductal, ductular, and acinar cells all have been declared the tumor progenitor cells. Our long-term human and experim...
-
Article
Localization of galectin-3 in normal and diseased pancreatic tissue
Galectin-3 is expressed in both human and hamster pancreatic tumors and tumor cell lines and this expression is increased over normal.
-
Chapter
Adenocarcinoma, Kidney, Syrian Hamster
Induced renal carcinomas have different sizes, locations, and macroscopic appearances. Small neoplasms are usually fround in the cortex; they may be cystic and grossly indistinguishable from cystadenomas. Larg...
-
Chapter
Adenoma, Kidney, Syrian Hamster
Small adenomas appear as pin-size, cystic, well demarcated lesions and may elevate the kidney surface. Larger adenomas are well delineated, grayish-white, firm or often cystic nodules of vrious sizes which are...
-
Chapter
Angioma, Angiosarcoma, Kidney, Syrian Hamster
Renal angiomas or angiosarcomas range from pinpoint size to over 10mm in diameter, are reddish and ill-defined, and usually have a subcapsular or capsular location. Large tumors may contain variously sized hem...
-
Article
Species differences in the expression of transforming growth factor-alpha (TGF-α) in the submandibular gland and pancreas
Significant differences exist in the expression of transforming growth factor-alpha (TGF-α) in the submandibular glands (SMG) and the pancreas of different species and among cell compo...
-
Article
Modification of blood group a expression in human pancreatic tumor cell lines by inhibitors ofN-glycan processing
Pancreatic adenocarcinomas induced in Syrian hamsters byN-nitrosobis(2-oxopropyl)amine (BOP) treatment express blood group A (BGA) antigen, which was previously shown by this lab to be expressed on multiantennary...
-
Article
A novel adhesion factor produced by hamster pancreatic cancer cell line is effective on normal and carcinoma cell lines of different species
An adhesion factor, produced by the hamster pancreatic cancer cell line PC-1.0, was tested for its efficiency in promoting the in vitro adhesion of normal and tumor cells (pancreas, lung, kidney, colon, breast...
-
Article
Establishment and characterization of a new, spontaneously immortalized, pancreatic ductal cell line from the Syrian golden hamster
Spontaneously immortal pancreatic cell lines are not available. By use of a defined culture medium, such a line (TAKA-1) was established from the Syrian golden hamster. Cytological, cytogenetic, molecular biol...
-
Article
The role of Langerhans islets in exocrine pancreatic cancer
-
Article
Plaeomorphic nonfunctioning islet cell tumor of the pancreas
A nonfunctioning islet cell tumor of the pancreas in a 68-yr-old female is reported. All of the laboratory data, including serum hormones, glucose, and tumor markers, were within normal limits A pancreatoduode...
-
Article
Investigational strategies for detection and intervention in early-stage pancreatic cancer
-
Article
Abstract of the Symposium
-
Article
The patterns of coexpression of tumor-associated antigens CA 19-9, TAG-72, and DU-PAN-2 in human pancreatic cancer
Coexpression of CA 19-9, DU-PAN-2, and TAG-72 was examined by a multilabeling immunohistochemical procedure in 31 surgically resected human pancreatic carcinomas. CA 19-9 was expressed in 74%, DU-PAN-2 in 84%,...
-
Article
Pancreatic centroacinar cells
The relationship between pancreatic centroacinar cells (CAC), the acinar cells, and the endocrine cells was examined in fetuses and newborn Syrian hamsters histologically, immunohistochemically, and electron m...
-
Article
A new multilabeling technique for simultaneous demonstration of different islet cells in permanent slides
We describe a simple immunohistochemical method for simultaneous demonstration of insulin, glucagon, somatostatin, and pancreatic polypeptide cells of the Langerhans islet in routinely fixed paraffin-embedded ...
