4 Result(s)
within
Parisa Azadnia
English
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Article
Open AccessPresenting native-like trimeric HIV-1 antigens with self-assembling nanoparticles
Structures of BG505 SOSIP.664 trimer in complex with broadly neutralizing antibodies (bNAbs) have revealed the critical role of trimeric context for immune recognition of HIV-1. Presentation of trimeric HIV-1 ...
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Article
Open AccessUncleaved prefusion-optimized gp140 trimers derived from analysis of HIV-1 envelope metastability
The trimeric HIV-1 envelope glycoprotein (Env) is critical for host immune recognition and neutralization. Despite advances in trimer design, the roots of Env trimer metastability remain elusive. Here we inves...
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Article
Open AccessApproaching rational epitope vaccine design for hepatitis C virus with meta-server and multivalent scaffolding
Development of a prophylactic vaccine against hepatitis C virus (HCV) has been hampered by the extraordinary viral diversity and the poor host immune response. Scaffolding, by grafting an epitope onto a hetero...
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Article
Open AccessToward a more accurate view of human B-cell repertoire by next-generation sequencing, unbiased repertoire capture and single-molecule barcoding
B-cell repertoire analysis using next-generation sequencing has become a valuable tool for interrogating the genetic record of humoral response to infection. However, key obstacles such as low throughput, shor...
