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Open AccessPresenting native-like trimeric HIV-1 antigens with self-assembling nanoparticles
Structures of BG505 SOSIP.664 trimer in complex with broadly neutralizing antibodies (bNAbs) have revealed the critical role of trimeric context for immune recognition of HIV-1. Presentation of trimeric HIV-1 ...
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Open AccessUncleaved prefusion-optimized gp140 trimers derived from analysis of HIV-1 envelope metastability
The trimeric HIV-1 envelope glycoprotein (Env) is critical for host immune recognition and neutralization. Despite advances in trimer design, the roots of Env trimer metastability remain elusive. Here we inves...
