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  1. Article

    Open Access

    Considerations and recommendations on traditional and non-traditional uses of excipients in oral drug products

    Excipients represent diverse classes of molecules, small molecules or macromolecules, with versatile structures within a given class and are from natural, semi-synthetic and synthetic sources. They are essenti...

    Panayiotis P. Constantinides, Subhashis Chakraborty, Dali Shukla in AAPS Open (2016)

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  2. No Access

    Article

    In Vitro and In Vivo Metabolic Studies of Phospho-aspirin (MDC-22)

    To investigate the metabolism of phospho-aspirin (PA, MDC-22), a novel anti-cancer and anti-inflammatory agent.

    Gang **e, Chi C. Wong, Ka-Wing Cheng, Liqun Huang… in Pharmaceutical Research (2012)

  3. No Access

    Article

    Phospho-Sulindac (OXT-328) Inhibits the Growth of Human Lung Cancer Xenografts in Mice: Enhanced Efficacy and Mitochondria Targeting by its Formulation in Solid Lipid Nanoparticles

    To evaluate the antitumor efficacy of solid lipid nanoparticle–encapsulated phospho-sulindac (SLN-PS) in human lung cancer.

    Rongrong Zhu, Ka-Wing Cheng, Gerardo Mackenzie, Liqun Huang… in Pharmaceutical Research (2012)

  4. No Access

    Article

    Sterically Stabilized Liposomes Incorporating the Novel Anticancer Agent Phospho-Ibuprofen (MDC-917): Preparation, Characterization, and In Vitro/In Vivo Evaluation

    To incorporate phospho-ibuprofen (P-I), a lipophilic, water insoluble novel anti-cancer agent, into pegylated liposomes and upon formulation optimization to evaluate its antitumor activity in vitro and in vivo.

    George Mattheolabakis, Ting Nie, Panayiotis P. Constantinides… in Pharmaceutical Research (2012)

  5. Article

    Open Access

    Protonated nanostructured aluminosilicate (NSAS) reduces plasma cholesterol concentrations and atherosclerotic lesions in Apolipoprotein E deficient mice fed a high cholesterol and high fat diet

    The aim of this work was to assess the effect of chronic administration of protonated nanostructured aluminosilicate (NSAS) on the plasma cholesterol levels and development of atherosclerotic lesions in Apolip...

    Olena Sivak, Jerry Darlington, Pavel Gershkovich… in Lipids in Health and Disease (2009)

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  6. No Access

    Article

    Advances in the Use of Tocols as Drug Delivery Vehicles

    There has been increasing interest in recent years in the drug delivery applications of tocols and their derivatives. Their biocompatibility and potential to deliver both poorly soluble and water-soluble drugs...

    Panayiotis P. Constantinides, Jihong Han, Stanley S. Davis in Pharmaceutical Research (2006)

  7. No Access

    Article

    Formulation Development and Antitumor Activity of a Filter-Sterilizable Emulsion of Paclitaxel

    Purpose. Paclitaxel is currently administered i.v. as a slow infusion of asolution of the drug in an ethanol:surfactant:saline admixture. However,poor solubilization and toxicity are associated with this drug th...

    Panayiotis P. Constantinides, Karel J. Lambert, Alex K. Tustian… in Pharmaceutical Research (2000)

  8. No Access

    Article

    Water-in-Oil Microemulsions Containing Medium-chain Fatty Acids/Salts: Formulation and Intestinal Absorption Enhancement Evaluation

    Purpose. Water-in-oil (w/o) microemulsions have been developed which, in addition to non-ionic medium-chain glycerides, incorporate ionic lipids, primarily medium-chain fatty acids, such as caprylic (C8) capric ...

    Panayiotis P. Constantinides, Gus Welzel, Harma Ellens… in Pharmaceutical Research (1996)

  9. No Access

    Article

    Lipid Microemulsions for Improving Drug Dissolution and Oral Absorption: Physical and Biopharmaceutical Aspects

    Purpose. This review highlights the state-of-the-art in pharmaceutical microemulsions with emphasis on self-emulsifying systems, from both a physical and biopharmaceutical perspective. Although these systems hav...

    Panayiotis P. Constantinides in Pharmaceutical Research (1995)

  10. No Access

    Article

    Formulation and Intestinal Absorption Enhancement Evaluation of Water-in-Oil Microemulsions Incorporating Medium-Chain Glycerides

    We developed self-emulsifying water-in-oil (w/o) microemulsions incorporating medium-chain glycerides and measured their conductance, viscosity, refractive index and particle size. Formulation of Calcein (a wa...

    Panayiotis P. Constantinides, Jean-Paul Scalart, Cindy Lancaster… in Pharmaceutical Research (1994)