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  1. Article

    Open Access

    The hippocampal fimbria of cuprizone-treated animals as a structure for studying neuroprotection in multiple sclerosis

    It has been demonstrated that changes in the normal-appearing white matter (NAWM) in multiple sclerosis precede the appearance of classical lesions. The understanding of NAWM biology in an established disease ...

    M. Kipp, A. Norkus, B. Krauspe, T. Clarner, K. Berger in Inflammation Research (2011)

  2. No Access

    Article

    Development of a New MnZn-Ferrite Soft Magnetic Material for High Temperature Power Applications

    At power electronic applications (e.g. in automotive, lighting, electrical equipment etc.) the inductive components that consist the heart of the power transformers are made of ceramic ferromagnetic materials ...

    V. Zaspalis, V. Tsakaloudi, E. Papazoglou, M. Kolenbrander in Journal of Electroceramics (2004)

  3. No Access

    Chapter

    Grey Matter Pathology in Multiple Sclerosis

    Multiple sclerosis (MS) is a CNS disease histopathologically characterized by discrete areas of myelin, oligodendrocyte, and axonal loss [1]. The etiology of MS is unknown, but environmental factors and multip...

    B. P. Brink, S. J. Mork, P. Van Der Valk in Normal-appearing White and Grey Matter Dam… (2004)

  4. No Access

    Article

    A Histopathological Contribution to Supratentorial Glioma Grading, Definition of Mixed Gliomas and Recognition of Low Grade Glioma With Rosenthal Fibers

    Background Previous glioma studies have described separate grading systems for oligodendrogliomas and astrocytomas. Many of these gliomas contain mixtures of neoplastic astrocytes and oligodendrocytes. Prognosis...

    J.M.J. Cillekens, J.A.M. Beliën, P. van der Valk, T.J.C. Faes in Journal of Neuro-Oncology (2000)

  5. No Access

    Article

    Malignant lymphoma of mucosa-associated lymphoid tissue in the larynx

    A 36-year-old woman was referred to the department of Otolaryngology / Head and Neck Surgery, University Hospital Vrije Universiteit, because of complaints of hoarseness. A submucosal swelling of the right ve...

    R. de Bree, H. F. Mahieu, G. J. Ossenkoppele in European Archives of Oto-Rhino-Laryngology (1998)

  6. No Access

    Article

    Enhanced expression of MMP-7 and MMP-9 in demyelinating multiple sclerosis lesions

    The pathology of multiple sclerosis (MS) is characterised by breakdown of the blood-brain barrier accompanied by infiltration of macrophages and T cells into the central nervous system (CNS). Myelin is degrade...

    Judy A. Cossins, John M. Clements, Janice Ford, Karen M. Miller in Acta Neuropathologica (1997)

  7. No Access

    Article

    MR imaging in retinoblastoma

    We studied the appearance of retinoblastoma on unenhanced and gadolinium-enhanced images and the accuracy of tumour staging with MR imaging. The MR images were obtained in 18 children with retinoblastoma and c...

    F. Barkhof, M. Smeets, P. van der Valk, K. E. W. P. Tan in European Radiology (1997)

  8. No Access

    Article

    p53 and P-glycoprotein are often co-expressed and are associated with poor prognosis in breast cancer

    Expression of both P-glycoprotein (P-gp) and mutant p53 have recently been reported to be associated with poor prognosis of breast cancer. The expression of P-gp is associated in vitro and in vivo with cross-r...

    SC Linn, AH Honkoop, K Hoekman, P van der Valk, HM Pinedo in British Journal of Cancer (1996)

  9. No Access

    Article

    Complement activation in amyloid plaques in Alzheimer's disease brains does not proceed further than C3

    In Alzheimer's disease (AD) patients, the complement components Clq, C4 and C3 can be detected in different types of β/A4 plaques, one of the hallmarks of AD. Contradictory findings on the presence of late com...

    R. Veerhuis, P. van der Valk, I. Janssen, S. S. Zhan, P. Eikelenboom in Virchows Archiv (1995)

  10. No Access

    Article

    Optimizing plant regeneration from seed-derived callus cultures of Kentucky bluegrass. The effect of benzyladenine

    The effect of benzyladenine (BA) on the production of shoot-forming callus from seeds of two Poa pratensis cultivars was studied. Addition of low concentrations (0.1–0.3 mg l-1) of BA to Murashige & Skoog (MS) ca...

    P. van der Valk, F. Ruis, A. M. Tettelaar-Schrier in Plant Cell, Tissue and Organ Culture (1995)

  11. No Access

    Article

    Castleman's disease as a uncommon cause of a neck mass

    Castleman's disease is an uncommon cause of a neck mass; in only 6% of the cases reported in the literature was the disease located in the neck. We present the case of a 21-year-old woman who developed a swell...

    D. P. Kooper, R. M. Tiwari, P. van der Valk in European Archives of Oto-Rhino-Laryngology (1994)

  12. No Access

    Article

    Cellular and substrate adhesion molecules (integrins) and their ligands in cerebral amyloid plaques in Alzheimer's disease

    Integrins belonging to different subfamilies can be identified immunohistochemically in cerebral amyloid plaques. Monoclonal antibodies against the VLA family β1-integrins show staining of the corona of classi...

    P. Eikelenboom, S. S. Zhan, W. Kamphorst, P. van der Valk in Virchows Archiv (1994)

  13. No Access

    Article

    Callus induction and plant regeneration from explants of commercial cultivars of leek (Allium ampeloprasum var. porrum L.)

    Plant regeneration capacity was studied for 8 cultivars and 4 accessions of leek (A. ampeloprasum var. porrum L.). Compact callus was induced on embryo and leaf explants on three different media. The highest freq...

    J. Buiteveld, P. van der Valk, J. Jansen, J. Creemers-Molenaar in Plant Cell Reports (1993)

  14. No Access

    Article

    Lobular panniculitis after subcutaneous administration of interleukin-2 (IL-2), and its exacerbation during intravenous therapy with IL-2

    Interleukin-2 (IL-2) is now registered for the treatment of renal cell carcinoma in a number of European countries. The subcutaneous (sc) route of administration is being used increasingly because of its bette...

    JW Baars, JLLM Coenen, J Wagstaff, P van der Valk, HM Pinedo in British Journal of Cancer (1992)

  15. No Access

    Article

    Micrometastases from squamous cell carcinoma in neck dissection specimens

    The incidence of micrometastases in cervical lymph nodes from squamous cell carcinomas of the head and neck was studied using routine histopathological examination. Micrometastases were found in 66 lymph nodes...

    M. W. M. van den Brekell, H. V. Stele in European Archives of Oto-Rhino-Laryngology (1992)

  16. No Access

    Article

    High frequency somatic embryogenesis and plant regeneration from zygotic embryo-derived callus cultures of three Allium species

    The plant regeneration ability of zygotic embryo-derived callus cultures was studied for 12 A. cepa varieties and accessions, two A. fistulosum varieties, one A. fistulosum x A. cepa interspecific hybrid and two

    P. van der Valk, O. E. Scholten, F. Verstappen in Plant Cell, Tissue and Organ Culture (1992)

  17. No Access

    Article

    Improvement of the tissue culture response of seed-derived callus cultures of Poa pratensis L.: Effect of gelling agent and abscisic acid

    The effects of gelling agent and abscisic acid on the morphogenetic response of seed-derived callus cultures of Poa pratensis L. were investigated. On medium solidified with Gelrite, the regeneration frequency of...

    H. F. Van Ark, M. A. C. M. Zaal in Plant Cell, Tissue and Organ Culture (1991)

  18. No Access

    Article

    Independent segregation of two isozyme markers and inter-plant differences in nuclear DNA content in the interspecific backcross (Allium fistulosum L. × A. cepa L.) × A. cepa L.

    From backcrosses of three interspecific hybrids (A. fistulosum x A. cepa) with a. cepa 14 diploid and 2 triploid plants were recovered.

    P. Van der Valk, C. Kik, F. Verstappen, J. T. Everink, J. N. de Vries in Euphytica (1991)

  19. No Access

    Article

    Sinonasal non-Hodgkin's lymphomas and Wegener's granulomatosis: A clinicopathological study

    Reports of sinonasal non-Hodgkin's lymphomas, analysed with monoclonal antibodies, are scarce, and differentiation of these lymphomas from Wegener's granulomatosis can be difficult. In this study, we investiga...

    L. A. Noorduyn, R. Torenbeek, P. van der Valk, P. B. Drosten in Virchows Archiv A (1991)

  20. No Access

    Article

    Pre- and post-fertilization barriers to backcrossing the interspecific hybrid between Allium fistulosum L. and A. cepa L. with A. cepa

    To facilitate the introgression of desirable traits of Allium fistulosum into the genome of A. cepa, several accessions of the hybrid between these species were pollinated with A. cepa as the recurrent parent, an...

    P. van der Valk, S. E. de Vries, J. T. Everink, F. Verstappen, J. N. de Vries in Euphytica (1991)

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