Skip to main content

and
  1. Article

    Open Access

    Effectiveness and process evaluation in obesity and type 2 diabetes prevention programs in children: a systematic review and meta-analysis

    Obesity in children is one of the most severe public health challenges of the current century and Type 2 Diabetes Mellitus (T2DM) frequency is also escalating. More so, the importance of process evaluation (PE...

    M. Seral-Cortes, P. De Miguel-Etayo, P. Zapata, M. L. Miguel-Berges in BMC Public Health (2021)

  2. Article

    Open Access

    Molecular and morphological characterization of new interspecific hybrids of alstroemeria originated from A. caryophylleae scented lines

    Alstroemeria is a genus native to South America from which many varieties of ornamental plants have been developed and introduced into the market. Interspecific hybridization followed by embryo rescue has been on...

    D. Aros, M. Suazo, C. Rivas, P. Zapata, C. Úbeda, M. Bridgen in Euphytica (2019)

  3. No Access

    Chapter

    Fifty Years of Progress in Carotid Body Physiology – Invited Article

    Research on arterial chemoreceptors, particularly on the carotid body, has been fruitful in the last fifty years, to which this review is addressed. The functional anatomy of the organ appears to be well estab...

    R.S. Fitzgerald, C. Eyzaguirre, P. Zapata in Arterial Chemoreceptors (2009)

  4. No Access

    Chapter

    Responses of Petrosal Ganglion Neurons in vitro to Hypoxic Stimuli and Putative Transmitters

    J. Alcayaga, R. Varas, J. Arroyo, R. Iturriaga, P. Zapata in Oxygen Sensing (2002)

  5. No Access

    Chapter

    Interactions Between Acetylcholine and Dopamine in Chemoreception

    P. Zapata, C. Larraín, R. Iturriaga, J. Alcayaga, C. Eyzaguirre in Oxygen Sensing (2002)

  6. No Access

    Chapter

    Domperidone as a Tool to Assess the Role of Dopamine within Carotid Body Chemoreception

    The carotid bodies are composite receptors, i.e. hypoxia apparently acts upon glomus cells which are synaptically apposed to the sensory endings of primary afferent neurons, responsible for conveying the informat...

    P. Zapata, R. Iturriaga, C. Larraín in Frontiers in Arterial Chemoreception (1996)

  7. No Access

    Chapter

    Coherence of Chemosensory Discharges in Cats’ Carotid Nerves

    The study of neural coding involves the analysis of four formal aspects: the referent (relevant features of the input), the transformation (encoding process), the transmission (anatomical and physiological substr...

    J. Alcayaga, R. Iturriaga, P. Zapata in Frontiers in Arterial Chemoreception (1996)

  8. No Access

    Chapter

    Dopamine Efflux from the Carotid Body During Hypoxic Stimulation

    The carotid bodies of cats are known to contain high levels of dopamine (DA), persisting even after complete denervation of these organs (Zapata et al, 1969; Mir et al, 1982; Fitzgerald et al, 1983). Thus DA a...

    P. Zapata, R. Iturriaga, J. Alcayaga in Frontiers in Arterial Chemoreception (1996)

  9. No Access

    Chapter

    Effects of Expiratory Duration on Chemoreceptor Oscillations

    We have studied the effect of suddenly altering the duration of expiration (TE) on the variations in the frequency of chemosensory discharges (fx) with respiration.

    R. W. Torrance, R. Iturriaga, P. Zapata in Arterial Chemoreceptors (1994)

  10. No Access

    Chapter

    The Carotid Bodies as Thermosensors: Experiments in Vitro and in Situ, and Importance for Ventilatory Regulation

    The carotid bodies are not only sensitive to changes in the chemical composition of the blood, but also to changes in flow, osmolality and temperature (Eyzaguirre & Zapata, 1984). We have been searching for th...

    P. Zapata, C. Larraín, R. Iturriaga, J. Alcayaga in Arterial Chemoreceptors (1994)

  11. No Access

    Chapter

    Thermal Effects Upon the Chemosensory Drive of Ventilation

    It has been shown that the frequency of chemosensory discharges recorded from carotid bodies superfused in vitro is highly dependent on temperature (Gallego et al., 1979), presenting both dynamic and static co...

    P. Zapata, C. Larrain, R. Fadic, B. Ramirez in Neurobiology and Cell Physiology of Chemor… (1993)

  12. No Access

    Chapter and Conference Paper

    Flow Detection by the Carotid Body

    The carotid bodies (CBs) of the cat are excited by occlusions of the common carotids (1), resulting in reflex hyperventilation (2). The CBs are also responsive to systemic hypotension, although less than the a...

    J. Alcayaga, R. Iturriaga, P. Zapata in Arterial Chemoreception (1990)

  13. No Access

    Chapter and Conference Paper

    Plasticity of Ventilatory Chemoreflexes

    The chemosensory neurons of the carotid (sinus) and aortic (depressor) nerves provide the input for the ventilatory chemoreflexes initiated by hypoxic stimulation. The central processes of these neurons conver...

    P. Zapata, J. Eugenín, C. Larraín in Arterial Chemoreception (1990)

  14. No Access

    Chapter

    Restoration of Chemoreflexes after Unilateral Carotid Deafferentation

    The main arterial chemoreceptor organs in mammals are the carotid and aortic bodies. Each carotid body receives its sensory innervation from the carotid (sinus) branch of the ipsilateral glossopharyngeal nerve...

    P. Zapata, C. Larrain, J. Eugenin in Chemoreceptors and Chemoreceptor Reflexes (1990)

  15. No Access

    Chapter

    Carotid Body Chemoreceptor Response to Transient Arterial Occlusion

    The occlusion of the common carotid artery is a classical manoeuvre to evoke a reflex increase in the systemic arterial pressure (Pa). This pressor response is usually ascribed to the withdrawal of carotid bar...

    P. Zapata, R. Iturriaga, J. Alcayaga in Chemoreceptors in Respiratory Control (1987)

  16. No Access

    Chapter

    Interference by Domperidone on Chemosensory and Ventilatory Responses to Dopamine

    The peripheral arterial chemoreceptors exert a tonic drive upon resting ventilation in normoxic eucapnic mammals as shown by the fall in tidal volume (VT) observed in response to breathing 100% O2 for a few secon...

    P. Zapata, F. Torrealba in Chemoreceptors in Respiratory Control (1987)

  17. No Access

    Chapter and Conference Paper

    Blockade of Carotid Body Chemosensory Inhibition

    There is a high content of dopamine in the carotid body (21), located in glomus type I cells by fluorescence microscopy (9). Intrastream injections of dopamine produced a transient depression of the frequency ...

    P. Zapata, F. Llados in Chemoreception in the Carotid Body (1977)

  18. No Access

    Chapter and Conference Paper

    Recovery of Chemosensory Function of Regenerating Carotid Nerve Fibers

    The site at which physiological stimuli elicit carotid nerve activation is still disputed. To evoke an increase in discharge in slowly adapting receptors (such as carotid body chemoreceptors), stimuli must dep...

    P. Zapata, L. J. Stensaas, C. Eyzaguirre in Chemoreception in the Carotid Body (1977)

  19. No Access

    Chapter and Conference Paper

    Origin of Nerve Terminals on Glomus Cells in Cat Carotid Body: A Study of Axoplasmic Movement of Labeled Material Along Sensory Neurons of the Petrosal Ganglion

    The site of termination of chemosensory fibers in the carotid body, once considered to be well established by the pioneering studies of de Castro (3), has been the object of renewed interest and speculation. D...

    S. Fidone, P. Zapata, L. J. Stensaas in Chemoreception in the Carotid Body (1977)

  20. No Access

    Article

    Effects of denervation and decentralization upon taste buds

    Denervation of vallate papillae results in failure of tactile and gustatory reception at a time when impulse conduction in the distal stump of the glossopharyngeal nerve is still unimpaired; delay of receptor ...

    J. A. Donoso, P. Zapata in Experientia (1976)