31 Result(s)

Article

Extra-axial chordoma: a clinicopathologic analysis of six cases

Extra-axial chordoma is an exceedingly rare tumor, with only 28 cases reported in the literature to date. Axial and extra-axial chordoma exhibits complete morphologic and immunophenotypic (expression of brachy...

A. Righi, M. Sbaraglia, M. Gambarotti, S. Cocchi, G. Drago, R. Casadei… in Virchows Archiv (2018)

Article

CD99 regulates neural differentiation of Ewing sarcoma cells through miR-34a-Notch-mediated control of NF-κB signaling

Sarcomas are mesenchymal tumors characterized by blocked differentiation process. In Ewing sarcoma (EWS) both CD99 and EWS-FLI1 concur to oncogenesis and inhibition of differentiation. Here, we demonstrate tha...

S Ventura, D N T Aryee, F Felicetti, A De Feo, C Mancarella, M C Manara… in Oncogene (2016)

Article

Sclerosing epithelioid fibrosarcoma of the thigh: report of two cases with synchronous bone metastases

We report two cases of sclerosing epithelioid fibrosarcoma occurring in the deep soft tissue of the thigh, confirmed by molecular analysis and associated with bone metastases in the lumbar vertebrae and the il...

A. Righi, M. Gambarotti, M. Manfrini, S. Benini, G. Gamberi, S. Cocchi… in Virchows Archiv (2015)

Article

Gene expression profiling of giant cell tumor of bone reveals downregulation of extracellular matrix components decorin and lumican associated with lung metastasis

Giant cell tumor of bone (GCTB) displays worrisome clinical features such as local recurrence and occasionally metastatic disease which are unpredictable by morphology. Additional routinely usable biomarkers d...

M. Lieveld, E. Bodson, G. De Boeck, B. Nouman, A. M. Cleton-Jansen… in Virchows Archiv (2014)

Article

CD99 suppresses osteosarcoma cell migration through inhibition of ROCK2 activity

CD99, a transmembrane protein encoded by MIC2 gene is involved in multiple cellular events including cell adhesion and migration, apoptosis, cell differentiation and regulation of protein trafficking either in ph...

C Zucchini, M C Manara, R S Pinca, P De Sanctis, C Guerzoni, M Sciandra… in Oncogene (2014)

Article

1q gain and CDT2 overexpression underlie an aggressive and highly proliferative form of Ewing sarcoma

Despite extensive characterization of the role of the EWS-ETS fusions, little is known about secondary genetic alterations and their clinical contribution to Ewing sarcoma (ES). It has been demonstrated that t...

C Mackintosh, J L Ordóñez, D J García-Domínguez, V Sevillano, A Llombart-Bosch… in Oncogene (2012)

Article

Efficacy of and resistance to anti-IGF-1R therapies in Ewing's sarcoma is dependent on insulin receptor signaling

Identification of patient selection criteria and understanding of the potential mechanisms involved in the development of resistance are crucial for an appropriate and successful design of clinical trials with...

C Garofalo, M C Manara, G Nicoletti, M T Marino, P-L Lollini, A Astolfi… in Oncogene (2011)

Article

Morphological and immunophenotypic features of primary and metastatic giant cell tumour of bone

Giant cell tumour of bone (GCTB) is a primary tumour of bone that may rarely, in the absence of malignant cytological features, produce metastatic lesions, most commonly in the lungs. Whether these lung nodule...

M. Alberghini, K. Kliskey, T. Krenacs, P. Picci, L. Kindblom, R. Forsyth… in Virchows Archiv (2010)

Article

Parosteal osteosarcoma dedifferentiating into telangiectatic osteosarcoma: importance of lytic changes and fluid cavities at imaging

This study was performed to assess the imaging findings in cases of parosteal osteosarcoma dedifferentiated into telangiectatic osteosarcoma. Parosteal osteosarcoma is a low-grade well-differentiated malignant...

M. Azura, D. Vanel, M. Alberghini, P. Picci, E. Staals, M. Mercuri in Skeletal Radiology (2009)

Article

CD99 isoforms dictate opposite functions in tumour malignancy and metastases by activating or repressing c-Src kinase activity

CD99 gene encodes two distinct proteins, produced by alternative splicing of CD99 gene transcript. Full-length CD99 isoform (CD99wt) is formed by an extracellular domain, followed by a transmembrane domain and a ...

K Scotlandi, M Zuntini, M C Manara, M Sciandra, A Rocchi, S Benini, G Nicoletti… in Oncogene (2007)

Article

Histologically verified lung metastases in benign giant cell tumours—14 cases from a single institution

From 1975 to 1997, 649 cases of benign giant cell tumours of the bone were treated at the Istituto Rizzoli. Fourteen patients (2.1%) experienced lung metastases after a mean of 35.2 months. The time interval b...

M. Dominkus, P. Ruggieri, F. Bertoni, A. Briccoli, P. Picci… in International Orthopaedics (2006)

Chapter

Prognostic and Therapeutic Targets in the Ewing's Family of Tumors (PROTHETS)

P. Picci, K. Scotlandi, M. Serra, A. Rizzi in New trends in cancer for the 21st century (2006)

Chapter

Autologous Peripheral Blood Stem Cell Transplantation in Childhood Metastatic Osteosarcoma

Over the past few years the outcome of patients with high grade osteosarcoma (OST) improved dramatically, with survival rates rising from 15% up to 70% [1]. The relatively large series of subjects reported by ...

R. Miniero, A. Busca, A. Brach del Prever… in Transplantation in Hematology and Oncology (2000)

Chapter

Autologous Peripheral Blood Stem Cell Transplantation in Childhood Metastatic Osteosarcoma

Over the past few years the outcome of patients with high grade osteosarcoma (OST) has improved dramatically with survival rates rising from 15% up to 70% [1]. The relatively large series of subjects reported ...

R. Miniero, A. Busca, A. Brach de Prever… in Transplantation in Hematology and Oncology (2000)

Article

Alveolar soft part sarcoma

 We present a rare case of alveolar soft-tissue sarcoma, with extensive bone invasion. The differential diagnosis with bone metastasis and primary bone tumors is dicscussed.

P. Aluigi, L. Sangiorgi, P. Picci in Skeletal Radiology (1996)

Chapter

Surgery of Osteosarcoma of the extremities: Indications and complications in the recent Experience at the Istituto Ortopedico Rizzoli

In the surgical treatment of localized osteosarcoma of the extremities, limb-salvage procedures are currently used whenever wide surgical margins can be achieved [1–3]. The increased indications for conservative ...

P. Ruggieri, R. Biagini, G. Bacci… in Osteosarcoma in Adolescents and Young Adul… (1993)

Chapter

Neoadjuvant chemotherapy for nonmetastatic osteosarcoma of the extremities: The recent experience at the Rizzoli Institute

In the late 1970s Rosen et al. was the first to report the advantages of primary chemotherapy and delayed surgery (neoadjuvant chemotherapy) over adjuvant chemotherapy. The excellent results reported by these ...

G. Bacci, P. Picci, S. Ferrari, M. Avella… in Osteosarcoma in Adolescents and Young Adul… (1993)