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Article
Open AccessPharmacokinetics of Monoclonal Antibodies Throughout Pregnancy: A Systematic Literature Review
Although little information is available on the pharmacokinetics (PK) of monoclonal antibodies (mAbs) during pregnancy, multiple mAbs are being used during pregnancy for various indications. The aim of this sy...
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Article
Open AccessComparing shear wave elastography with liver biopsy in the assessment of liver fibrosis at King Hussein Medical Center
The aim of this prospective study is to compare the sensitivity and specificity of the liver shear wave elastography to the golden standard liver biopsy in staging liver fibrosis.
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Article
Assessment of radiological impacts of natural radionuclides and radon exhalation rate measured in the soil samples of Himalayan foothills of Uttarakhand, India
In order to assess the radiological baseline, the terrestrial radionuclide contents (226Ra, 232Th, and 40K) and radon exhalation rate were measured in the soil samples collected from the vicinity of Himalayan foo...
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Article
Indicative mean transit time estimation from δ18O values as groundwater vulnerability indicator in karst-fissure aquifers
Ideally, groundwater vulnerability assessment should take into account potential contaminant breakthrough curve, characterized by transit time, relative change of contamination concentration (input/output) and...
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Article
Genetic characterization and phylogenetic analysis of host-range genes of Camelpox virus isolates from India
Camelpox virus (CMLV), a close variant of variola virus (VARV) infects camels worldwide. The zoonotic infections reported from India signify the need to study the host-range genes—responsible for host tropism....
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Oxygen Isotope Composition Snapshot of Spring Waters in a Karstified Plateau
In the period of September 10–21, 2002, 317 km2 of Muránska planina karstic plateau (Slovakia) was mapped for springs in great detail. Within this short time interval, 295 springs were documented and also sampled...
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Article
Genetic Analysis of the Neuraminidase (NA) Gene of Equine Influenza Virus (H3N8) from Epizootic of 2008–2009 in India
The neuraminidase (NA) gene sequences of four Indian equine influenza viruses (EIVs) isolated from epizootic in 2008 and 2009 were analyzed. The phylogenetic relationship and selection pressure of NA genes wer...
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Article
Critical Variables affecting clinical-grade production of the self-inactivating gamma-retroviral vector for the treatment of X-linked severe combined immunodeficiency
Patients with X-linked severe combined immunodeficiency (SCID-X1) were successfully cured following gene therapy with a gamma-retroviral vector (gRV) expressing the common gamma chain of the interleukin-2 rece...
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Article
Scale-up and manufacturing of clinical-grade self-inactivating γ-retroviral vectors by transient transfection
The need for γ-retroviral (gRV) vectors with a self-inactivating (SIN) design for clinical application has prompted a shift in methodology of vector manufacturing from the traditional use of stable producer li...
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Chapter
Use of Combined Recession Curves Analyses of Neighbouring Karstic Springs to Reveal Karstification Degree of Groundwater Springing Routes
In the southern part of the Slovenský Kras Mts., positioned on the territory of Hungarian–Slovak transboundary karstic hydrogeological structure of Dolný vrch/Alsóhegy, several karstic springs occur. Hydrograp...
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Article
The woodchuck hepatitis virus post-transcriptional regulatory element reduces readthrough transcription from retroviral vectors
The woodchuck hepatitis virus post-transcriptional regulatory element (WPRE) increases transgene expression from a variety of viral vectors, although the precise mechanism is not known. WPRE is most effective ...
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Article
Epidemiology of Severe Sepsis in Intensive Care Units in the Slovak Republic
We investigated the number, clinical characteristics, and outcomes of ICU patients, who met precise clinical and physiological criteria for severe sepsis (as defined in the PROWESS study) in Slovak intensive c...
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Article
Recent advances on the chemistry of solvent extraction applied to the reprocessing of spent nuclear fuels and radioactive wastes
After a brief description of the PUREX process as a starting point, this paper aims to point out some of its most recent developments, always from the viewpoint of the chemistry involved in the solvent extract...
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Article
Comparative Analysis of the Outer Membrane Protein Profiles of Isolates of the Pasteurella multocida (B:2) Associated with Haemorrhagic Septicaemia
Outer membrane proteins (OMP) of P. multocida (serotype B:2) field isolates (n = 6) and a vaccine strain (P-52) were extracted by a sarkosyl method and characterized using SDS-PAGE and immunoblotting. About 20 po...
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Article
Extraction of uranium, thorium and lanthanides using Cyanex-923: Their separations and recovery from monazite
The extraction behavior of uranium, thorium and lanthanides, represented by cerium and ytterbium, by Cyanex-923 has been investigated. The effect of different variables like the concentration of acids, metal i...
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Article
Extraction chromatographic studies of Ti(IV) with cyanex 301 as impregnant—Recovery from red mud
A silica gel column impregnated with bis-(2,4,4-trimethylpentyl)dithiophosphinic acid has been studied for the uptake of Ti(IV). Its chemical stability has been examined and its regeneration power checked. The...
