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  1. Article

    T- and B-cell responses to multivalent prime-boost DNA and viral vectored vaccine combinations against hepatitis C virus in non-human primates

    Immune responses against multiple epitopes are required for the prevention of hepatitis C virus (HCV) infection, and the progression to phase I trials of candidates may be guided by comparative immunogenicity ...

    C S Rollier, E J Verschoor, B E Verstrepen, J A R Drexhage… in Gene Therapy (2016)

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    Article

    Codon optimization and mRNA amplification effectively enhances the immunogenicity of the hepatitis C virus nonstructural 3/4A gene

    We have recently shown that the NS3-based genetic immunogens should contain also hepatitis C virus (HCV) nonstructural (NS) 4A to utilize fully the immunogenicity of NS3. The next step was to try to enhance im...

    L Frelin, G Ahlén, M Alheim, O Weiland, C Barnfield, P Liljeström… in Gene Therapy (2004)

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    Article

    Low dose and gene gun immunization with a hepatitis C virus nonstructural (NS) 3 DNA-based vaccine containing NS4A inhibit NS3/4A-expressing tumors in vivo

    The hepatitis C virus (HCV) protease and helicase encompasses the nonstructural (NS) 3 protein and the cofactor NS4A, which targets the NS3/4A-complex to intracellular membranes. We here evaluate the importanc...

    L Frelin, M Alheim, A Chen, J Söderholm, B Rozell, C Barnfield… in Gene Therapy (2003)

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    Article

    Recombinant Semliki Forest virus vaccine vectors: the route of injection determines the localization of vector RNA and subsequent T cell response

    Vectors based on Semliki Forest virus (SFV) have been widely used in vitro and in vivo to express heterologous genes in animal cells. In particular, the ability of recombinant SFV (rSFV) to elicit specific, pr...

    P Colmenero, P Berglund, T Kambayashi, P Biberfeld, P Liljeström, M Jondal in Gene Therapy (2001)

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    Article

    A conserved leucine in the cytoplasmic domain of the Semliki Forest virus spike protein is important for budding

     Budding of alphaviruses at the plasma membrane has been shown to depend on specific amino acids of the spike protein and hydrophobic cavities of the nucleocapsid. Here the function of leucine401 in the cytopl...

    U. Skoging-Nyberg, P. Liljeström in Archives of Virology (2000)

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    Chapter

    Alphavirus Vectors: Highly Efficient Systems for Transient Gene Expression

    Alphaviruses are enveloped viruses containing a single positive strand RNA molecule as genome. Expression vectors based on alphaviruses have been developed from Sindbis virus (SIN), Semliki Forest virus (SFV),...

    C. Smerdou, P. Liljeström in Cell Engineering (2000)

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    Article

    Induction of P815 tumor immunity by recombinant Semliki Forest virus expressing the P1A gene

    The methylcholantrene-induced P815 mastocytoma tumor is derived from DBA/2 mice and expresses a weak tumor rejection antigen, P815A. The P1A gene, which encodes for the P815A antigen, is silent in most normal ...

    P Colmenero, P Liljeström, M Jondal in Gene Therapy (1999)

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    Article

    Cloning of human IL-12 p40 and p35 DNA into the Semliki Forest virus vector: expression of IL-12 in human tumor cells

    IL-12 can enhance the development of effective immune responses against tumors as well as against certain infectious agents. It is therefore a potential candidate for therapeutic use in cancer therapy and in t...

    J Zhang, C Asselin-Paturel, F Bex, J Bernard, J Chehimi, F Willems… in Gene Therapy (1997)

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    Article

    The Tax transactivation protein of human T-cell leukemia virus type I colocalizes with NF-κB proteins in nuclear bodies

    F. Bex, A. McDowall, P. Liljeström, A. Burny… in Journal of Cancer Research and Clinical On… (1995)

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    Chapter and Conference Paper

    Assembly and entry mechamisms of Semliki Forest virus

    The alphavirus Semliki Forest (SFV) is an enveloped virus with a positive single-stranded RNA genome. The genome is complexed with 240 copies of a capsid protein into a nucleocapsid structure. In the membrane ...

    Dr. H. Garoff, J. Wilschut, P. Liljeström, J. M. Wahlberg… in Positive-Strand RNA Viruses (1994)