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  1. No Access

    Article

    A genome-wide scan points to a susceptibility locus for bipolar disorder on chromosome 12

    Our previous results pointed to a putative gene for susceptibility to bipolar affective disorder located on the chromosomal region 12q23–q24 that segregated in the Saguenay-Lac-St-Jean population of Quebec. We...

    E Shink, J Morissette, R Sherrington, N Barden in Molecular Psychiatry (2005)

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    Chapter

    Presenilin Proteins and the Pathogenesis of Early-Onset Familial Alzheimer’s Disease: β-Amyloid Production and Parallels to Prion Diseases

    In contrast to rare mutations in the amyloid presursor protein (APP) gene, missense mutations in the presenilin 1 (PS1) and presenilin 2 (PS2) genes, on chromosomes 14 and 1 respectively, are the most common c...

    D. Westaway, G. A. Carlson, C. Bergeron… in Prions and Brain Diseases in Animals and H… (1998)

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    Article

    Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene

    WE report the cloning of a novel gene (E5-1) encoded on chromosome 1 which has substantial nucleotide and amino-acid sequence similarity to the S182 gene on chromosome 14q24.3. Mutations, including three new miss...

    E. I. Rogaev, R. Sherrington, E. A. Rogaeva, G. Levesque, M. Ikeda, Y. Liang… in Nature (1995)

  4. No Access

    Article

    Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

    Some cases of Alzheimer's disease are inherited as an autosomal dominant trait. Genetic linkage studies have mapped a locus (AD3) associated with susceptibility to a very aggressive form of Alzheimer's disease to...

    R. Sherrington, E. I. Rogaev, Y. Liang, E. A. Rogaeva, G. Levesque, M. Ikeda… in Nature (1995)