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Open AccessLate effects in survivors of infantile acute leukemia: a study of the L.E.A program
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Prevalence and risk factors of iron overload after hematopoietic stem cell transplantation for childhood acute leukemia: a LEA study
Data on post-transplant iron overload (IO) are scarce in pediatrics. We conducted a prospective multicenter cohort study (Leucémie de l’Enfant et de l’Adolescent cohort) to determine the prevalence and risk fa...
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Preclinical Studies of Pegylated- and Non-Pegylated Liposomal Forms of Doxorubicin as Radiosensitizer on Orthotopic High-Grade Glioma Xenografts
Free doxorubicin (DXR) is not currently used to treat brain tumors because (i) the blood–brain barrier limits the drug deposition into the brain (ii) lethal toxic effects occur when combined with radiation the...
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Health status of childhood leukemia survivors who received hematopoietic cell transplantation after BU or TBI: an LEA study
The purpose of this multicenter study was to compare the long-term impact of a preparative regimen with either BUBU or TBI on health status and quality of life (QoL) in childhood acute leukemia survivors treat...
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Are ARID5B and IKZF1 polymorphisms also associated with childhood acute myeloblastic leukemia: the ESCALE study (SFCE)?
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Genetic polymorphisms and childhood acute lymphoblastic leukemia: GWAS of the ESCALE study (SFCE)
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Growth hormone treatment impact on growth rate and final height of patients who received HSCT with TBI or/and cranial irradiation in childhood: a report from the French Leukaemia Long-Term Follow-Up Study (LEA)
The literature contains a substantial amount of information about factors that adversely influence the linear growth in up to 85% of patients undergoing haematopoietic SCT (HSCT) with TBI and/or cranial irradi...
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Standards, Options: Recommandations pour I’indication des agents stimulant l’érythropoïèse (ASE: époétine alpha, époétine bêta et darbépoétine) dans la prise en charge de l’anémie en cancérologie (mise à jour 2007), rapport abrégé
Dès 1998, un groupe de travail d’experts, mis en place par la Fédération nationale des centres de lutte contre le cancer (FNCLCC), a publié puis a mis à jour régulièrement des recommandations pour l’indication...
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Open AccessIncidence and prognostic value of tumour cells detected by RT–PCR in peripheral blood stem cell collections from patients with Ewing tumour
To retrospectively evaluate the incidence of tumour cell contamination of peripheral blood stem cell (PBSC) collections and to correlate these data with the clinical outcome after high-dose chemotherapy (HDCT)...
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Open AccessDose finding and O6-alkylguanine-DNA alkyltransferase study of cisplatin combined with temozolomide in paediatric solid malignancies
Cisplatin may have additive activity with temozolomide due to ablation of the DNA repair protein O6-alkylguanine-DNA alkyltransferase (MGMT). This phase I/II study determined recommended combination doses using t...
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Individualized treatment of craniopharyngioma in children: ways and means
Medium- and long-term prognosis of craniopharyngioma is overwhelmed by the risks of hypothalamic and visual impairment. This problem has been underestimated for a long time because the major concern for the ne...
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Open AccessLocalised and unresectable neuroblastoma in infants: excellent outcome with low-dose primary chemotherapy
The purpose of this study was to evaluate the efficacy of low-dose chemotherapy in infants with localised and unresectable neuroblastoma (NB). All consecutive infants with localised NB and no N-myc amplification ...
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Open AccessTreatment of stage 4s neuroblastoma – report of 10 years' experience of the French Society of Paediatric Oncology (SFOP)
Stage 4s neuroblastoma (NB) is usually associated with a favourable outcome, despite a large tumour burden, as spontaneous regression frequently occurs. However, in some infants rapid disease progression can b...
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Open AccessPhase I trial and pharmacological study of a 3-hour paclitaxel infusion in children with refractory solid tumours: a SFOP study
The maximum tolerated dose of paclitaxel administered by 24-hour continuous infusion in children is known. Short infusion might offer equivalent antitumour efficacy and reduced haematological toxicity, without...
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Open AccessAdverse outcome of infants with metastatic neuroblastoma, MYCN amplification and/or bone lesions: results of the French Society of Pediatric Oncology
To assess the relevance of MYCN amplification and bone lesions in stage 4 neuroblastoma (NB) in infants aged <1 year, 51 infants with stage 4 NB were enrolled. Three groups of patients were defined according t...
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Open AccessChemotherapy for unresectable and recurrent intramedullary glial tumours in children
Adjuvant treatment for intramedullary tumours is based on radiotherapy. The place of chemotherapy in this setting has yet to be determined. Between May 1992 and January 1998, eight children with unresectable o...
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Open AccessCombined treatment modality for intracranial germinomas: results of a multicentre SFOP experience
Conventional therapy for intracranial germinomas is craniospinal irradiation. In 1990, the Société Française d’Oncologie Pédiatrique initiated a study combining chemotherapy (alternating courses of etoposide–c...
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Unresectable localized neuroblastoma: improved survival after primary chemotherapy including carboplatin-etoposide
Neuroblastomas (NBs) were assessed according to INSS recommendations including MIBG scan and extensive bone marrow staging to eliminate metastatic spread. Patients with unresectable tumour received primary che...
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Inflammatory pseudotumour of the lung
