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Article
Médicaments et grossesse : aspects néonatals
L’impact sur le nouveau-né d’un traitement maternel en cours de grossesse est souvent considéré uniquement sous l’angle malformatif. Or, lorsqu’il a lieu en fin de grossesse, un traitement maternel n’expose pa...
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Article
One Year Outcome in Infants Studied for Hemodynamic and Eeg Disturbances After Instillation of Natural vs Synthetic Surfactant. 8
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Article
Early-onset septicemia in a newborn due to a penicillin resistant pneumococcus probably transmitted during delivery
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Article
ENDOTHELIN (ET-1). ENDOTHELIN 3 (ET-3) AND BIG ENDOTHELIN (BigET) LEVELS IN CSF AND ARTERIAL BLOOD DURING HYPER AND HYPOCAPNIA IN PIGLETS
To determine possible vascular mediators that might explain cerebrovascular paralysie associated with perinatal asphyxia, the levels of ET-1, ET-3 and BigET were studied in 6 lightly anesthetized ventilated 1-...
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Article
Clonazepam in neonatal seizures: dose regimens and therapeutic efficacy
The attempt has been made to define the optimal dose regimen of clonazepam in newborns suffering from neonatal convulsions.
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Article
158 MYOCARDIC DEPRESSION WITH PHENOBARBITAL (PB) MAY AFFECT CEREBRAL HAEMODYNAMIC DURING HYPOXEMIA
PB proposed to reduce brain damage after birth induce also cardiac depression. To analyse the effects of PB on cerebral and systemic haemodynamics during hypoxemia. 15 piglets (< 10 days) paralysed (Pancuroniu...
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Article
Placental transfer and perinatal pharmacokinetics of betaxolol
Betaxolol levels in blood were monitored in the perinatal period in 28 pregnant hypertensive women and in their babies.
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Article
EFFECT OF SYMPATHETIC INNERVATION ON CEREBRAL BLOOD FLOW AUTOREGULATION IN THE NEWBORN PIGLET
To evaluate the role of the sympathetic nervous system (SNS) in cerebral blood flow autoregulation (CBF-AR) in the neonatal period, CBF was measured (microspheres) at different levels of mean arterial blood pr...
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Article
Treatment of persistent fetal circulation syndrome of the newborn. Comparison of different doses of tolazoline
The effects of two doses of tolazoline have been compared in 2 groups of newborns suffering from the persistent fetal circulation syndrome. The effects on PaO2 and AaDO2 were similar in the 2 groups who received ...
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Article
Doxapram (DX) for apnea (A) of prematurity; effects on pulmonary function
8 preterm infants GA ± SD, 30.5 ± 1.6 wks, BW 1.4 ± 0.2 kg, mean age 4.6 ± 2.6 d, presenting ≥ 3 idiopathic A/24h, ≥ 15s + bradycardia ≤ 100 bpm, received IV DX either 0.25 mg/kg/h (DX1) or 1 mg/kg/h (DX2) the...
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Article
Phenobarbital (PB) restores cerebral blood flow (CBF) autoregulation after seizures(S) in the newborn Piglet
CBF autoregulation is impaired after experimental S in the neonatal period; to analyse the effect of PB on this phenomenon, CBF is measured (microspheres) in the postictal period in 3 groups of newborn piglets...
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Article
To nurse when receiving acebutolol: Is it dangerous for the neonate?
The concentrations of acebutolol and of its main active metabolite diacetolol in milk and plasma were studied in 7 hypertensive mothers treated with acebutolol, a cardioselective β-adrenoceptor blocking agent....
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Article
Clonazepam pharmacokinetics and therapeutic efficacy in neonatal seizures
Eighteen newborns (gestational age 28 to 42 weeks and post-natal age 0.5 to 44 days) suffering from convulsions not controlled by phenobarbital were treated with clonazepam 0.1 mg/kg (8 cases) or 0.2 mg/kg (10...
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Article
AROUSAL (AR), APNEA AND SIGHING FOLLOWING LARYNGEAL STIMULATION (LS) IN SLEEPING TERM NEWBORN LAMBS
A sigh frequently occurs following LS induced apnea. It has been shown that AR improves the respiratory recovery from such apnea in slee** premature newborn lambs. This study was designed to evaluate the rel...
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Article
REGIONAL CEREBRAL BLOOD FLOW (CBF) DURING BICUCULLINE INDUCED SEIZURES (S) IN THE NEWBORN PIGLET WITH OR WITHOUT PHENOBARBITAL (PB)
In adult animals, S induce important alterations in CBF, which have not been evaluated in the neonatal period. Thus, we measured CBF before, during and 15 min after S induced by IV bicuculline (.6 to 1.2 mg/kg...
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Article
RETINAL SUPEROXIDE DISMUTASE ACTIVITY IN NEWBORN KITTENS EXPOSED TO NORMOBARIC HYPEROXIA EFFECT OF VITAMIN E
Summary: Total superoxide dismutase activity (SOD) was measured in the retinas obtained from 18 kittens aged 1 to 11 days born to 6 litters. Pretreatment with 100 mg of α-tocopherol acetate S.C. followed by a ...
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Article
Pharmacokinetics of furosemide in neonates
The pharmacokinetics of furosemide was evaluated in 12 newborns who received the drug transplacentally, and in 21 neonates who received it directly for therapeutic reasons. In the first group, the apparent pla...
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Article
Effectiveness and pharmacokinetics of indomethacin in premature newborns with patent ductus arteriosus
A review of the published data on pharmacological closure of PDA in premature newborns shows that doses of 0.2 mg/kg indomethacin are less successful when given enterally (18 to 85% closure) than when given in...
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Chapter and Conference Paper
Computerized Tomography in Premature Infants — Normal Appearances
Neurological disorders are common in the neonatal period, especially in premature infants. The computerised tomographic (C.T.) aspects of intraventricular haemorrhage are now fairly well known. However parench...
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Article
Giant lobar emphysema — Neonatal diagnosis
Giant emphysema of a lung lobe has distinctive features. Classically there is overdistension of the affected lung lobe, with one lobe only being involved, and, 50% of cases occur in the newborn infant [1, 4, 8].
