Abstract
PB proposed to reduce brain damage after birth induce also cardiac depression. To analyse the effects of PB on cerebral and systemic haemodynamics during hypoxemia. 15 piglets (< 10 days) paralysed (Pancuronium 0.1 mg/kg) and ventilated are studied (GrI, PB 20mg/kg, n=7, GrII, controls, n=8). Cerebral blood flow (CBF) and cardiac index (CI) are measured (micro spheres) at baseline and during hypoxemia (CO exposure). MABP, PaO2, PaCO2, pH, SaO2 and available Hb for O2 transport (Hba: total Hb minus HBCO) are evaluated for moderate (Hba 1/3 to 2/3 of Hb total) and severe hypoxemia (Hba < 1/3 of total Hb). Stroke volume (SV) heart rate (HR) and double preduct (DP: systolic BP × HR) assessing myocardial oxygenation are calculated
For moderate hypoxemia, CBF is increased in the 2 groups. In severe hypoxemia, CBF rose further in gr II only. In gr I Cl and DP were significantly decreased. These data suggest that for severe hypoxemia PB may significantly affect cerebral haemodynamics in relation to myocardial depression. a:p<.005, b:p<0.1 vs baseline, c:p<.01 vs moderate hypoxemia
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Monin, P., Cortey, A., Hascoet, J. et al. 158 MYOCARDIC DEPRESSION WITH PHENOBARBITAL (PB) MAY AFFECT CEREBRAL HAEMODYNAMIC DURING HYPOXEMIA. Pediatr Res 28, 303 (1990). https://doi.org/10.1203/00006450-199009000-00182
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DOI: https://doi.org/10.1203/00006450-199009000-00182
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