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Article
Open AccessPathobiological implications of the d16HER2 splice variant for stemness and aggressiveness of HER2-positive breast cancer
We have previously shown that the d16HER2 splice variant is linked to HER2-positive breast cancer (BC) tumorigenesis, progression and response to Trastuzumab. However, the mechanisms by which d16HER2 contribut...
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Article
CD49d prevails over the novel recurrent mutations as independent prognosticator of overall survival in chronic lymphocytic leukemia
CD49d, the alpha-chain of the integrin heterodimer α4β1, was identified among the strongest predictors of overall survival (OS) in chronic lymphocytic leukemia (CLL), along with IGHV mutational status and deletio...
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Article
Open AccessHuman responses against HER-2-positive cancer cells in human immune system-engrafted mice
Human immune system (HIS)-engrafted mice are new tools to investigate human immune responses. Here, we used HIS mice to study human immune responses against human HER-2-positive cancer cells and their ability ...
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Article
ADI nutritional recommendations for dysphagia
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Article
Artificial nutrition: technical, scientific and ethical considerations
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Article
CD99 isoforms dictate opposite functions in tumour malignancy and metastases by activating or repressing c-Src kinase activity
CD99 gene encodes two distinct proteins, produced by alternative splicing of CD99 gene transcript. Full-length CD99 isoform (CD99wt) is formed by an extracellular domain, followed by a transmembrane domain and a ...
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Article
CD49d in B-cell chronic lymphocytic leukemia: correlated expression with CD38 and prognostic relevance
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Article
Reply to Pittner et al.
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Article
Mutational status of IgVH genes in B-cell chronic lymphocytic leukemia and prognosis: percent mutations or antigen-driven selection?
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Article
Wild-type p53-mediated down-modulation of interleukin 15 and interleukin 15 receptors in human rhabdomyosarcoma cells
We recently reported that rhabdomyosarcoma cell lines express and secrete interleukin 15 (IL-15), a tightly regulated cytokine with IL-2-like activity. To test whether the p53-impaired function that is frequen...
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Article
Therapy of murine mammary carcinoma metastasis with interferon γ and MHC gene-transduced tumour cells
Gene-transfected tumour cells were used to cure mice bearing lung metastases by the parental, non-transduced mammary adenocarcinoma (TSA-pc). Repeated subcutaneous (s.c.) administrations of mitomycin C (MitC)-...
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Article
Redundancy of autocrine loops in human rhabdomyosarcoma cells: induction of differentiation by suramin
Three human rhabdomyosarcoma cell lines were used to investigate the presence of autocrine loops based on the production of insulin-like growth factor (IGF)-II, basic fibroblast growth factor (bFGF) and epider...
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Article
Decreased adhesion to endothelial cells and matrix proteins of H-2Kb gene transfected tumour cells
Transfection of murine metastatic B78H1 cells (derived from B16 melanoma) with a syngeneic H-2Kb gene was used to study the effect of Major Histocompatibility Complex (MHC) gene products on tumour cell adhesio...
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Article
Uncoupling of growth inhibition and differentiation in dexamethasone-treated human rhabdomyosarcoma cells
The effects of dexamethasone, a synthetic glucocorticoid, and of N,N-dimethylformamide on in vitro growth and differentiation and on proto-oncogene expression of human rhabdomyosarcoma cells were studied. RD/1...
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Article
Control of H-2 expression in transformed nonhaemopoietic cells by autocrine interferon
The relationship between autocrine interferon (IFN) production and the expression of class I Major Histocompatibility Complex (MHC) membrane glycoproteins in vitro was investigated in a panel of murine transfo...
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Article
Induction of myogenic differentiation in human rhabdomyosarcoma cells by ionising radiation, N,N-dimethylformamide and their combination
Differentiation-inducing ability of gamma-radiation, N,N-dimethylformamide and their combination has been tested on human rhabdomyosarcoma RMZ-RC2 clone cells. Ionising radiation at 2-5 Gy doses induced a more...
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Article
In vitro differentiation of rhabdomyosarcomas induced by nickel or by Moloney murine sarcoma virus
In vitro cultures and clonal derivatives have been established from rat rhabdomyosarcomas induced by Moloney-Murine Sarcoma Virus (MSV) or by nickel sulfide; differentiation ability has been studied as express...
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Article
Enhancement of experimental metastatic ability by tumor necrosis factor-alpha alone or in combination with interferon-gamma
The effects of recombinant tumor necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma) on B16 mouse melanoma experimental metastatic ability and major histocompatibility complex (H-2b) antigens expre...
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Article
Late abstracts 186–187
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Article
RMZ: A new cell line from a human alveolar rhabdomyosarcoma. In vitro expression of embryonic myosin
The RMZ cell line was established from a bone marrow metastasis of a human alveolar rhabdomyosarcoma. Since the beginning of the in vitro culture, RMZ cells showed differentiation-related morphological heterogene...
