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  1. No Access

    Article

    Contributions of the Raf/MEK/ERK, PI3K/PTEN/Akt/mTOR and Jak/STAT pathways to leukemia

    Mutations and chromosomal translocations occur in leukemic cells that result in elevated expression or constitutive activation of various growth factor receptors and downstream kinases. The Raf/MEK/ERK, PI3K/P...

    L S Steelman, S L Abrams, J Whelan, F E Bertrand, D E Ludwig, J Bäsecke… in Leukemia (2008)

  2. No Access

    Article

    Targeting survival cascades induced by activation of Ras/Raf/MEK/ERK, PI3K/PTEN/Akt/mTOR and Jak/STAT pathways for effective leukemia therapy

    The Raf/MEK/ERK, PI3K/PTEN/Akt/mTOR and Jak/STAT pathways are frequently activated in leukemia and other hematopoietic disorders by upstream mutations in cytokine receptors, aberrant chromosomal translocations...

    J A McCubrey, L S Steelman, S L Abrams, F E Bertrand, D E Ludwig, J Bäsecke… in Leukemia (2008)

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    Article

    Human myeloma cells express the bone regulating gene Runx2/Cbfa1 and produce osteopontin that is involved in angiogenesis in multiple myeloma patients

    Osteopontin (OPN) is a multifunctional bone matrix glycoprotein that is involved in angiogenesis, cell survival and tumor progression. In this study we show that human myeloma cells directly produce OPN and ex...

    S Colla, F Morandi, M Lazzaretti, R Rizzato, P Lunghi, S Bonomini, C Mancini… in Leukemia (2005)

  4. Article

    Erratum: Arsenic trioxide (ATO) and MEK1 inhibition synergize to induce apoptosis in acute promyelocytic leukemia cells

    Correction to: Leukemia (2005), 19, 234–244. doi:10.1038/sj.leu.2403585 The authors have identified that the name of the coauthor P Pelicci and his affiliation are incomplete. The correct name and affiliation ...

    P Lunghi, A Tabilio, F Lo-Coco, P Pelicci, A Bonati in Leukemia (2005)

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  5. No Access

    Article

    Arsenic trioxide (ATO) and MEK1 inhibition synergize to induce apoptosis in acute promyelocytic leukemia cells

    Recent studies suggest that components of the prosurvival signal transduction pathways involving the Ras-mitogen-activated protein kinase (MAPK) can confer an aggressive, apoptosis-resistant phenotype to leuke...

    P Lunghi, A Tabilio, F Lo-Coco, P Pelicci, A Bonati in Leukemia (2005)

  6. No Access

    Article

    Downmodulation of ERK protein kinase activity inhibits VEGF secretion by human myeloma cells and myeloma-induced angiogenesis

    The mitogen-activated protein (MAP) cascade leading to the activation of extracellular signal-regulated kinases 1/2 (ERK1/2) is critical for regulating myeloma cell growth; however, the relationship of ERK1/2 ...

    N Giuliani, P Lunghi, F Morandi, S Colla, S Bonomini, M Hojden, V Rizzoli… in Leukemia (2004)

  7. No Access

    Article

    Downmodulation of ERK activity inhibits the proliferation and induces the apoptosis of primary acute myelogenous leukemia blasts

    MAP kinase/ERK kinase (MEK)-extracellular signal-regulated kinase (ERK) kinases are frequently activated in acute myelogenous leukemia (AML), and can have prosurvival function. The purpose of this study was to...

    P Lunghi, A Tabilio, P P Dall'Aglio, E Ridolo, C Carlo-Stella, P G Pelicci… in Leukemia (2003)