38 Result(s)

Article

Molecular architecture of the DED chains at the DISC: regulation of procaspase-8 activation by short DED proteins c-FLIP and procaspase-8 prodomain

The CD95/Fas/APO-1 death-inducing signaling complex (DISC), comprising CD95, FADD, procaspase-8, procaspase-10, and c-FLIP, has a key role in apoptosis induction. Recently, it was demonstrated that procaspase-...

K Schleich, J H Buchbinder, S Pietkiewicz, T Kähne… in Cell Death & Differentiation (2016)

Article

Induction of apoptosis by IFNγ in human neuroblastoma cell lines through the CD95/CD95L autocrine circuit

F Bernassola, C Scheuerpflug, I Herr, P H Krammer… in Cell Death & Differentiation (2015)

Article

Tax contributes apoptosis resistance to HTLV-1-infected T cells via suppression of Bid and Bim expression

The human T-lymphotropic virus type 1 (HTLV-1) is the etiological agent of adult T-cell leukemia (ATL). HTLV-1 Tax has been shown to have a prosurvival role in infected T cells by enhancing expression of the B...

A Mühleisen, M Giaisi, R Köhler, P H Krammer, M Li-Weber in Cell Death & Disease (2014)

Article

The traditional Chinese medical compound Rocaglamide protects nonmalignant primary cells from DNA damage-induced toxicity by inhibition of p53 expression

One of the main obstacles of conventional anticancer therapy is the toxicity of chemotherapeutics to normal tissues. So far, clinical approaches that aim to specifically reduce chemotherapy-mediated toxicities...

M S Becker, P Schmezer, R Breuer, S F Haas, M A Essers, P H Krammer… in Cell Death & Disease (2014)

Article

Regulation of CD95/Fas signaling at the DISC

CD95 (APO-1/Fas) is a member of the death receptor (DR) family. Stimulation of CD95 leads to induction of apoptotic and non-apoptotic signaling pathways. The formation of the CD95 death-inducing signaling comp...

I N Lavrik, P H Krammer in Cell Death & Differentiation (2012)

Article

Caspase-8 activity has an essential role in CD95/Fas-mediated MAPK activation

Stimulation of CD95/Fas/APO-1 results in the induction of both apoptotic and non-apoptotic signaling pathways. The processes regulating these two opposing pathways have not been thoroughly elucidated to date. ...

A M M Kober, S Legewie, C Pforr, N Fricker, R Eils, P H Krammer… in Cell Death & Disease (2011)

Article

Wogonin and related natural flavones are inhibitors of CDK9 that induce apoptosis in cancer cells by transcriptional suppression of Mcl-1

The wogonin-containing herb Scutellaria baicalensis has successfully been used for curing various diseases in traditional Chinese medicine. Wogonin has been shown to induce apoptosis in different cancer cells and...

G Polier, J Ding, B V Konkimalla, D Eick, N Ribeiro, R Köhler… in Cell Death & Disease (2011)

Article

Modulation of CD4⁺ T-cell activation by CD95 co-stimulation

CD95 is a dual-function receptor that exerts pro- or antiapoptotic effects depending on the cellular context, the state of activation, the signal threshold and the mode of ligation. In this study, we report th...

M Paulsen, S Valentin, B Mathew, S Adam-Klages, U Bertsch… in Cell Death & Differentiation (2011)

Article

Rocaglamide breaks TRAIL resistance in HTLV-1-associated adult T-cell leukemia/lymphoma by translational suppression of c-FLIP expression

The human T-cell leukemia virus type-1 (HTLV-1)-associated adult T-cell leukemia/lymphoma (ATL) is incurable by currently known therapies. ATL samples and cell lines derived from ATL patients show restricted s...

M Bleumink, R Köhler, M Giaisi, P Proksch, P H Krammer… in Cell Death & Differentiation (2011)

Article

Rocaglamide sensitizes leukemic T cells to activation-induced cell death by differential regulation of CD95L and c-FLIP expression

Drugs with tumor selectivity may have an important benefit in chemotherapies. We have previously shown that Rocaglamide(s), derived from the medicinal plant Aglaia, kills various leukemic cells through the mitoch...

J Y Zhu, M Giaisi, R Köhler, W W Müller, A Mühleisen… in Cell Death & Differentiation (2009)

Article

EMBO workshop on cytotoxicity, cell death and the immune system

A Anel, C Bleackley, C Borner, P Golstein, P H Krammer… in Cell Death & Differentiation (2009)

Article

CD4/CXCR4-mediated cell death in AIDS

E Ritsou, R Breitkreutz, A Benner, T Böhler, M A Weigand… in Cell Death & Differentiation (2007)

Article

Sustained JNK signaling by proteolytically processed HPK1 mediates IL-3 independent survival during monocytic differentiation

We studied monocytic differentiation of primary mouse progenitor cells to understand molecular mechanisms of differentiation. We found a tightly controlled non-apoptotic activation of caspase-3 that correlated...

R Arnold, C R Frey, W Müller, D Brenner, P H Krammer… in Cell Death & Differentiation (2007)

Article

Specific resistance upon lentiviral TRAIL transfer by intracellular retention of TRAIL receptors

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) selectively induces apoptosis in many transformed cells, suggesting TRAIL as an ideal candidate for cancer gene therapy. A main obstacle in cance...

T Wenger, J Mattern, R Penzel, N Gassler, T L Haas… in Cell Death & Differentiation (2006)

Article

The role of CAP3 in CD95 signaling: new insights into the mechanism of procaspase-8 activation

Formation of the CD95 (APO-1/Fas) death inducing signaling complex (DISC) plays a central role in CD95 signaling. Previously, CD95 DISC composition was analyzed by two-dimensional gel electrophoresis and four ...

A Golks, D Brenner, I Schmitz, C Watzl, A Krueger… in Cell Death & Differentiation (2006)

Article

Control of neuronal branching by the death receptor CD95 (Fas/Apo-1)

The CD95 (Apo-1/Fas)/CD95 ligand (CD95L) system is best characterized as a trigger of apoptosis. Nevertheless, despite broad expression of CD95L and CD95 in the develo** brain, absence of functional CD95 (lpr m...

C Zuliani, S Kleber, S Klussmann, T Wenger, M Kenzelmann… in Cell Death & Differentiation (2006)

Article

TAp73/ΔNp73 influences apoptotic response, chemosensitivity and prognosis in hepatocellular carcinoma

We investigated the mechanisms by which TAp73β and dominant-negative p73 (ΔNp73) regulate apoptosis. TAp73β transactivated the CD95 gene via the p53-binding site in the first intron. In addition, TAp73β induced e...

M Müller, T Schilling, A E Sayan, A Kairat, K Lorenz… in Cell Death & Differentiation (2005)

Article

Dual role of the anti-inflammatory sesquiterpene lactone: regulation of life and death by parthenolide

M Li-Weber, K Palfi, M Giaisi, P H Krammer in Cell Death & Differentiation (2005)

Article

Enhanced caspase-8 recruitment to and activation at the DISC is critical for sensitisation of human hepatocellular carcinoma cells to TRAIL-induced apoptosis by chemotherapeutic drugs

Tumour necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) exhibits potent antitumour activity upon systemic administration in mice without showing the deleterious side effects observed with other ...

T M Ganten, T L Haas, J Sykora, H Stahl, M R Sprick… in Cell Death & Differentiation (2004)