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Article
Open AccessWogonin and related natural flavones are inhibitors of CDK9 that induce apoptosis in cancer cells by transcriptional suppression of Mcl-1
The wogonin-containing herb Scutellaria baicalensis has successfully been used for curing various diseases in traditional Chinese medicine. Wogonin has been shown to induce apoptosis in different cancer cells and...
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Chapter
Use of Mircoinjection to Study Apoptosis and its Prevention
Programmed cell death is an intrinsic death program operating to remove unwanted cells during embryonal development. It has also been suggested to eliminate cells which have acquired growth factor-independent ...
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Chapter and Conference Paper
Regulation of c-myc and Immunoglobulin κ Gene Transcription by Promoter-proximal Pausing of RNA Polymerase II
In normal cells, the proto-oncogene c-myc is regulated by promoter-proximal pausing of RNA polymerase II (pol II). In Burkitt lymphoma cells, c-myc is chromosomally translocated to one of the three immunoglobulin...
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Article
Mechanisms of G2/M-checkpoint control in ultraviolet B-irradiated keratinocytes
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Article
Transcriptional down-regulation of c-myc in human prostate carcinoma cells by the synthetic androgen mibolerone
The mechanism of down-regulation of c-myc RNA associated with androgen-induced suppression of the transformed phenotype in the human prostate carcinoma cell line LNCaP was investigated. The synthetic androgen ...
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Chapter and Conference Paper
Burkitt’s Lymphoma Variant Translocations: Distribution of Chromosomal Breakpoints and Perturbated Regulation of a Mutated c-myc Gene
Variant translocations in Burkitt’s lymphoma have the breakpoint of the chromosomal translocation 3’ of c-myc on chromosome 8 and 5’ of immunoglobulin kappa or lambda light chain constant genes on chromosome 2...
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Chapter and Conference Paper
Altered c-myc RNA Metabolism in Burkitt’s Lymphomas and Mouse Plasmacytomas
Exon 1 deleted c-myc RNAs found in some mouse plasma cell tumors (Piechaczyk et al., 1985) and Burkitt’s lymphomas (Eick et al., 1985) are more stable than their normal counterparts in control cells. In this p...
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Chapter
On the Mechanism of Recombination Between Adenoviral and Cellular DNAs: The Structure of Junction Sites
The integration of adenovirus DNA into host cell DNA was studied in considerable detail in abortively and productively infected cells, as well as in transformed and tumor cells induced by human adenoviruses (f...