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  1. Article

    Open Access

    Wogonin and related natural flavones are inhibitors of CDK9 that induce apoptosis in cancer cells by transcriptional suppression of Mcl-1

    The wogonin-containing herb Scutellaria baicalensis has successfully been used for curing various diseases in traditional Chinese medicine. Wogonin has been shown to induce apoptosis in different cancer cells and...

    G Polier, J Ding, B V Konkimalla, D Eick, N Ribeiro, R Köhler in Cell Death & Disease (2011)

  2. No Access

    Chapter

    Use of Mircoinjection to Study Apoptosis and its Prevention

    Programmed cell death is an intrinsic death program operating to remove unwanted cells during embryonal development. It has also been suggested to eliminate cells which have acquired growth factor-independent ...

    F. Kohlhuber, H. Hermeking, D. Eick in Microinjection (1999)

  3. No Access

    Chapter and Conference Paper

    Regulation of c-myc and Immunoglobulin κ Gene Transcription by Promoter-proximal Pausing of RNA Polymerase II

    In normal cells, the proto-oncogene c-myc is regulated by promoter-proximal pausing of RNA polymerase II (pol II). In Burkitt lymphoma cells, c-myc is chromosomally translocated to one of the three immunoglobulin...

    E. E. Schneider, T. Albert, D. A. Wolf, D. Eick in Mechanisms of B Cell Neoplasia 1998 (1999)

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    Article

    Mechanisms of G2/M-checkpoint control in ultraviolet B-irradiated keratinocytes

    J. O. Funk, T. Herzinger, K. Hillmer in Journal of Cancer Research and Clinical On… (1995)

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    Article

    Transcriptional down-regulation of c-myc in human prostate carcinoma cells by the synthetic androgen mibolerone

    The mechanism of down-regulation of c-myc RNA associated with androgen-induced suppression of the transformed phenotype in the human prostate carcinoma cell line LNCaP was investigated. The synthetic androgen ...

    DA Wolf, F Kohlhuber, P Schulz, F Fittler, D Eick in British Journal of Cancer (1992)

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    Chapter and Conference Paper

    Burkitt’s Lymphoma Variant Translocations: Distribution of Chromosomal Breakpoints and Perturbated Regulation of a Mutated c-myc Gene

    Variant translocations in Burkitt’s lymphoma have the breakpoint of the chromosomal translocation 3’ of c-myc on chromosome 8 and 5’ of immunoglobulin kappa or lambda light chain constant genes on chromosome 2...

    B. Henglein, M. Lipp, P. Hartl, S. Adolph in Mechanisms in B-Cell Neoplasia 1988 (1988)

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    Chapter and Conference Paper

    Altered c-myc RNA Metabolism in Burkitt’s Lymphomas and Mouse Plasmacytomas

    Exon 1 deleted c-myc RNAs found in some mouse plasma cell tumors (Piechaczyk et al., 1985) and Burkitt’s lymphomas (Eick et al., 1985) are more stable than their normal counterparts in control cells. In this p...

    M. Piechaczyk, A. Bonnieu, D. Eick, E. Remmers, J-Q. Yang in Mechanisms in B-Cell Neoplasia (1986)

  8. No Access

    Chapter

    On the Mechanism of Recombination Between Adenoviral and Cellular DNAs: The Structure of Junction Sites

    The integration of adenovirus DNA into host cell DNA was studied in considerable detail in abortively and productively infected cells, as well as in transformed and tumor cells induced by human adenoviruses (f...

    W. Doerfler, R. Gahlmann, S. Stabel, R. Deuring in The Molecular Biology of Adenoviruses 1 (1983)