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Open AccessFear extinction rescuing effects of dopamine and L-DOPA in the ventromedial prefrontal cortex
The ventromedial prefrontal cortex (vmPFC; rodent infralimbic cortex (IL)), is posited to be an important locus of fear extinction-facilitating effects of the dopamine (DA) bio-precursor, L-DOPA, but this hypo...
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Article
Discovery of a NAPE-PLD inhibitor that modulates emotional behavior in mice
N-acylethanolamines (NAEs), which include the endocannabinoid anandamide, represent an important family of signaling lipids in the brain. The lack of chemical probes that modulate NAE biosynthesis in living sys.....
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Article
Open AccessIdentification of a novel gene regulating amygdala-mediated fear extinction
Recent years have seen advances in our understanding of the neural circuits associated with trauma-related disorders, and the development of relevant assays for these behaviors in rodents. Although inherited f...
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Article
Open AccessFluoxetine Facilitates Fear Extinction Through Amygdala Endocannabinoids
Pharmacologically elevating brain endocannabinoids (eCBs) share anxiolytic and fear extinction-facilitating properties with classical therapeutics, including the selective serotonin reuptake inhibitor, fluoxet...
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Article
GluN2B in corticostriatal circuits governs choice learning and choice shifting
Corticostriatal NMDARs mediate certain learning and executive functions. Here Brigman et al. demonstrate that the NMDAR GluN2B subunit in dorsolateral striatum of mice is important for learning a behavioral choic...
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Article
Open AccessTemporal factors in the extinction of fear in inbred mouse strains differing in extinction efficacy
Various neuropsychiatric conditions, including posttraumatic stress disorder (PTSD), are characterized by deficient fear extinction, but individuals differ greatly in risk for these. While there is growing evi...
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Article
Chronic alcohol remodels prefrontal neurons and disrupts NMDAR-mediated fear extinction encoding
Alcoholism and post-traumatic stress disorder are frequently co-morbid. The authors show that chronic intermittent exposure to ethanol impairs extinction of fear conditioning in mice. In vivo recordings showed th...
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Open AccessHistone deacetylase inhibitors, glutamatergic drugs and deep brain stimulation rescue resistance to fear extinction in a genetic mouse model
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Article
Agonist-dependent attenuation of μ-opioid receptor-mediated G-protein activation in the dorsal root ganglia of neuropathic rats
Besides generally accepted lower analgesic potencies of opioids in neuropathic pain, our recent pharmacological reports have demonstrated that the effectiveness of the μ-opioid receptor (MOR) agonists in neuro...
