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  1. No Access

    Article

    Spacer prioritization in CRISPR–Cas9 immunity is enabled by the leader RNA

    CRISPR–Cas systems store fragments of foreign DNA, called spacers, as immunological recordings used to combat future infections. Of the many spacers stored in a CRISPR array, the most recent are known to be pr...

    Chunyu Liao, Sahil Sharma, Sarah L. Svensson, Anuja Kibe… in Nature Microbiology (2022)

  2. No Access

    Article

    Evolutionary classification of CRISPR–Cas systems: a burst of class 2 and derived variants

    The number and diversity of known CRISPR–Cas systems have substantially increased in recent years. Here, we provide an updated evolutionary classification of CRISPR–Cas systems and cas genes, with an emphasis on ...

    Kira S. Makarova, Yuri I. Wolf, Jaime Iranzo… in Nature Reviews Microbiology (2020)

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    Chapter

    CRISPR and Salty: CRISPR-Cas Systems in Haloarchaea

    CRISPR-Cas (CRISPR: Clustered Regularly Interspaced Short Palindromic Repeats and Cas: CRISPR associated) systems are unique defence mechanisms since they are able to adapt to new invaders and are heritable. CRIS...

    Lisa-Katharina Maier, Omer S. Alkhnbashi… in RNA Metabolism and Gene Expression in Arch… (2017)

  4. No Access

    Article

    An updated evolutionary classification of CRISPR–Cas systems

  5. CRISPR–Cas systems provide archaea and bacteria with adaptive immunity against viruses and plasmids.

  6. CRISPR...

    7. Kira S. Makarova, Yuri I. Wolf, Omer S. Alkhnbashi… in Nature Reviews Microbiology (2015)