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Article
Open AccessTargeted depletion of TRBV9+ T cells as immunotherapy in a patient with ankylosing spondylitis
Autoimmunity is intrinsically driven by memory T and B cell clones inappropriately targeted at self-antigens. Selective depletion or suppression of self-reactive T cells remains a holy grail of autoimmune ther...
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Article
B cells, plasma cells and antibody repertoires in the tumour microenvironment
Recent data show that B cells and plasma cells located in tumours or in tumour-draining lymph nodes can have important roles in sha** antitumour immune responses. In tumour-associated tertiary lymphoid struc...
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Article
Memory CD4+ T cells are generated in the human fetal intestine
The fetus is thought to be protected from exposure to foreign antigens, yet CD45RO+ T cells reside in the fetal intestine. Here we combined functional assays with mass cytometry, single-cell RNA sequencing and hi...
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Article
Open AccessVDJviz: a versatile browser for immunogenomics data
The repertoire of T- and B-cell receptor sequences encodes the antigen specificity of adaptive immunity system, determines its present state and guides its ability to mount effective response against encounter...
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Article
Towards error-free profiling of immune repertoires
A two-step error correction process for high throughput–sequenced T- and B-cell receptors allows the elimination of most errors while not diminishing the natural complexity of the repertoires.
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Article
MiTCR: software for T-cell receptor sequencing data analysis
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Article
Single high-dose treatment with glucosaminyl-muramyl dipeptide is ineffective in treating ankylosing spondylitis
Earlier studies have shown that high doses of TNF-alpha increase apoptosis in human autoimmune T-cell clones. Based on these studies, a treatment approach was proposed to reduce or eliminate autoimmune T cells...
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Article
Contribution of functional KIR3DL1 to ankylosing spondylitis
Increasing evidence points to a role for killer immunoglobulin-like receptors (KIRs) in the development of autoimmune diseases. In particular, a positive association of KIR3DS1 (activating receptor) and a negativ...
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Article
Near-infrared fluorescent proteins
Random and targeted mutagenesis of the far-red fluorescent protein Katushka followed by screening for low toxicity and red-shifted emission resulted in two near-infrared fluorescent proteins, eqFP650 and eqFP6...
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Article
Chromophore-assisted light inactivation (CALI) using the phototoxic fluorescent protein KillerRed
The phototoxic red fluorescent GFP-like protein KillerRed has recently been described. The phototoxicity of KillerRed exceeds that of EGFP by at least 1,000-fold, making it the first fully genetically encoded ...
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Article
A genetically encoded photosensitizer
Photosensitizers are chromophores that generate reactive oxygen species (ROS) upon light irradiation1. They are used for inactivation of specific proteins by chromophore-assisted light inactivation (CALI) and for...
