22 Result(s)
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Article
Association studies of genetic scores of serum vitamin B12 and folate levels with symptoms of depression and anxiety in two danish population studies
Observational studies have suggested low serum levels of vitamin B12 or folate to be risk factors of depression and anxiety. However, these results may be biased by confounding and reverse causation. Mendelian...
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Mendelian randomisation study of the associations of vitamin B12 and folate genetic risk scores with blood pressure and fasting serum lipid levels in three Danish population-based studies
The aim was to examine the association of genetic risk scores (GRSs) of vitamin B12 and folate-associated variants with blood pressure and lipids.
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Article
Prenatal exposure to systemic antibacterials and overweight and obesity in Danish schoolchildren: a prevalence study
Prenatal exposure to antibacterials may permanently dysregulate fetal metabolic patterns via epigenetic pathways or by altering maternal microbiota. We examined the association of prenatal exposure to systemic...
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Article
Open AccessSpecific gut microbiota features and metabolic markers in postmenopausal women with obesity
Gut microbial gene richness and specific bacterial species are associated with metabolic risk markers in humans, but the impact of host physiology and dietary habits on the link between the gut microbiota and ...
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Article
Open AccessTreatment with a GLP-1 receptor agonist diminishes the decrease in free plasma leptin during maintenance of weight loss
Recent studies indicate that glucagon-like peptide (GLP)-1 inhibits appetite in part through regulation of soluble leptin receptors. Thus, during weight loss maintenance, GLP-1 receptor agonist (GLP-1RA) admin...
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Open Access3.3: Associations Between Plasma Incretin Hormone Release and Aortic Stiffness and Blood Pressure in Individuals Without Known Diabetes: The Addition-Pro Study
The role of incretin hormone release on vascular structure and function remains unclear. Hence, in 836 Danish individuals without know diabetes and without antihypertensive treatment, we examined the associati...
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Article
The frequent UCP2 −866G>A polymorphism protects against insulin resistance and is associated with obesity: a study of obesity and related metabolic traits among 17 636 Danes
Uncoupling protein 2 (UCP2) is involved in regulating ATP synthesis, generation of reactive oxygen species and glucose-stimulated insulin secretion in β-cells. Polymorphisms in UCP2 may be associated with obesity...
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Open AccessBeyond the fourth wave of genome-wide obesity association studies
Obesity and related complications are major health burdens. Almost 700 million adults are currently obese globally and the prevalence is predicted to rise towards 2030. The sudden change of lifestyle with phys...
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Article
Common variants near MC4R in relation to body fat, body fat distribution, metabolic traits and energy expenditure
Common variants near melanocortin receptor 4 (MC4R) have been related to fatness and type 2 diabetes. We examined the associations of rs17782313 and rs17700633 in relation to body fat, body fat distribution, meta...
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Macronutrient-specific effect of FTO rs9939609 in response to a 10-week randomized hypo-energetic diet among obese Europeans
The A risk allele of rs9939609 of the fat mass- and obesity-associated gene (FTO) increases body fat mass.
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Article
Several obesity- and nutrient-related gene polymorphisms but not FTO and UCP variants modulate postabsorptive resting energy expenditure and fat-induced thermogenesis in obese individuals: the NUGENOB Study
Part of the heterogeneity of the obesity phenotype may originate from genetic differences between obese individuals that may influence energy expenditure (EE).
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Article
Impact on weight dynamics and general growth of the common FTO rs9939609: a longitudinal Danish cohort study
We investigated the impact of the fatness-related FTO rs9939609 A-allele on cross-sectional and longitudinal measures of body mass index (BMI), height and lean body mass (LBM) in a unique cohort representing a br...
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Article
Genetic analysis of the estrogen-related receptor α and studies of association with obesity and type 2 diabetes
The estrogen-related receptor α (ERRα or NR3B1) is a transcription factor from the nuclear receptor super-family, group III. The gene encoding ERRα (ESRRA) is located on chromosome 11q13, a region showing genetic...
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Randomized, multi-center trial of two hypo-energetic diets in obese subjects: high- versus low-fat content
To investigate whether a hypo-energetic low-fat diet is superior to a hypo-energetic high-fat diet for the treatment of obesity.
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Article
Lower-body fat mass as an independent marker of insulin sensitivity—the role of adiponectin
To study the association between lower-body fat and estimates of whole-body insulin sensitivity in middle-aged men with and without a history of juvenile onset obesity, and to determine the possible mediating ...
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Article
Interactions between physical activity and variants of the genes encoding uncoupling proteins −2 and −3 in relation to body weight changes during a 10-y follow-up
To examine interactions between physical activity and possibly functional variants of the genes encoding uncoupling proteins −2 and −3 in relation to body weight change. We hypothesize that physical inactivity...
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A meta-analytic investigation of linkage and association of common leptin receptor (LEPR) polymorphisms with body mass index and waist circumference
Methods: We analyzed data pooled from nine studies on the human leptin receptor (LEPR) gene for the association of three alleles (K109R, Q223R and K656N) of LEPR with body mass index (BMI; kg/m2) and waist circum...
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Article
The Asn363Ser variant of the glucocorticoid receptor gene is not associated with obesity or weight gain in Danish men
OBJECTIVE: Testing association of the Asn363Ser variant of the glucocorticoid gene with measures of obesity and weight gain.
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Article
The association between the val/ala-55 polymorphism of the uncoupling protein 2 gene and exercise efficiency
BACKGROUND: Energy expenditure may partly be determined by genetic variations in uncoupling proteins. We have previously found an increased physical activity but a similar 24-h energy expenditure (EE) in subjects...
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Article
Impact of the v/v 55 polymorphism of the uncoupling protein 2 gene on 24‐h energy expenditure and substrate oxidation
OBJECTIVE: The gene that codes for a novel uncoupling protein, UCP2, has been linked to obesity in animal models. Markers encompassing the UCP2 locus have been linked to energy expenditure in humans. We studied t...
