21 Result(s)

Article

EHMTI-0380. The association of migraine susceptibility loci with severe migraine characteristics in a clinic-based migraine sample

A Esserlind, AF Christensen, S Steinberg, N Grarup… in The Journal of Headache and Pain (2014)

Article

Exome sequencing-driven discovery of coding polymorphisms associated with common metabolic phenotypes

Human complex metabolic traits are in part regulated by genetic determinants. Here we applied exome sequencing to identify novel associations of coding polymorphisms at minor allele frequencies (MAFs) >1% with...

A. Albrechtsen, N. Grarup, Y. Li, T. Sparsø, G. Tian, H. Cao, T. Jiang… in Diabetologia (2013)

Article

Common variation in oxidative phosphorylation genes is not a major cause of insulin resistance or type 2 diabetes

There is substantial evidence that mitochondrial dysfunction is linked to insulin resistance and is present in several tissues relevant to the pathogenesis of type 2 diabetes. Here, we examined whether common ...

L. S. Snogdal, M. Wod, N. Grarup, M. Vestmar, T. Sparsø, T. Jørgensen… in Diabetologia (2012)

Article

Association studies of novel obesity-related gene variants with quantitative metabolic phenotypes in a population-based sample of 6,039 Danish individuals

Genome-wide association studies have identified novel WHR and BMI susceptibility loci. The aim of this study was to elucidate if any of these loci had an effect on quantitative measures of glucose homeostasis,...

K. S. Burgdorf, A. P. Gjesing, N. Grarup, J. M. Justesen, C. H. Sandholt… in Diabetologia (2012)

Article

Homozygous carriers of the G allele of rs4664447 of the glucagon gene (GCG) are characterised by decreased fasting and stimulated levels of insulin, glucagon and glucagon-like peptide (GLP)-1

The glucagon gene (GCG) encodes several hormones important for energy metabolism: glucagon, oxyntomodulin and glucagon-like peptide (GLP)-1 and -2. Variants in GCG may associate with type 2 diabetes, obesity and/...

S. S. Torekov, L. Ma, N. Grarup, B. Hartmann, I. A. Hainerová, U. Kielgast… in Diabetologia (2011)

Article

Erratum to: Type 2 diabetes risk allele near CENTD2 is associated with decreased glucose-stimulated insulin release

T. Nielsen, T. Sparsø, N. Grarup, T. Jørgensen, C. Pisinger, D. R. Witte… in Diabetologia (2011)

Article

Type 2 diabetes risk allele near CENTD2 is associated with decreased glucose-stimulated insulin release

By combining multiple genome-wide association (GWA) studies and comprehensive replication efforts, 12 novel type 2 diabetes associated loci have recently been discovered. Here we evaluate the effect of lead va...

T. Nielsen, T. Sparsø, N. Grarup, T. Jørgensen, C. Pisinger, D. R. Witte… in Diabetologia (2011)

Article

The diabetogenic VPS13C/C2CD4A/C2CD4B rs7172432 variant impairs glucose-stimulated insulin response in 5,722 non-diabetic Danish individuals

A genome-wide association study in the Japanese population reported two genome-wide significant loci associated with type 2 diabetes of which the VPS13C/C2CD4A/C2CD4B locus was replicated in Europeans. We looked ...

N. Grarup, M. Overvad, T. Sparsø, D. R. Witte, C. Pisinger, T. Jørgensen… in Diabetologia (2011)

Article

Glucose tolerance, insulin sensitivity and insulin release in European non-diabetic carriers of a polymorphism upstream of CDKN2A and CDKN2B

The aim of this study was to investigate the association of the rs10811661 polymorphism near the CDKN2B/CDKN2A genes with glucose tolerance, insulin sensitivity and insulin release in three samples of white peopl...

M. L. Hribal, I. Presta, T. Procopio, M. A. Marini, A. Stančáková… in Diabetologia (2011)

Article

Carriers of the TCF7L2 rs7903146 TT genotype have elevated levels of plasma glucose, serum proinsulin and plasma gastric inhibitory polypeptide (GIP) during a meal test

The transcription factor 7-like 2 (TCF7L2) rs7903146 T allele associates with type 2 diabetes in several populations, possibly mediated via decreased incretin secretion and/or action and altered beta and alpha ce...

A. P. Gjesing, L. L. Kjems, M. A. Vestmar, N. Grarup, A. Linneberg… in Diabetologia (2011)

Article

Type 2 diabetes risk alleles near ADCY5, CDKAL1 and HHEX-IDE are associated with reduced birthweight

The fetal insulin hypothesis suggests that variation in the fetal genotype influencing insulin secretion or action may predispose to low birthweight and type 2 diabetes. We examined associations between 25 con...

E. A. Andersson, K. Pilgaard, C. Pisinger, M. N. Harder, N. Grarup… in Diabetologia (2010)

Article

Variants at DGKB/TMEM195, ADRA2A, GLIS3 and C2CD4B loci are associated with reduced glucose-stimulated beta cell function in middle-aged Danish people

A meta-analysis of 21 genome-wide association studies identified 11 novel genetic loci implicated in fasting glucose homeostasis. We aimed to evaluate the impact of these variants on insulin release and insuli...

T. W. Boesgaard, N. Grarup, T. Jørgensen, K. Borch-Johnsen, T. Hansen… in Diabetologia (2010)

Article

A variant in the G6PC2/ABCB11 locus is associated with increased fasting plasma glucose, increased basal hepatic glucose production and increased insulin release after oral and intravenous glucose loads

An association between elevated fasting plasma glucose and the common rs560887 G allele in the G6PC2/ABCB11 locus has been reported. In Danes we aimed to examine rs560887 in relation to plasma glucose and serum i...

C. S. Rose, N. Grarup, N. T. Krarup, P. Poulsen, L. Wegner, T. Nielsen… in Diabetologia (2009)

Article

Combined analysis of 19 common validated type 2 diabetes susceptibility gene variants shows moderate discriminative value and no evidence of gene–gene interaction

The list of validated type 2 diabetes susceptibility variants has recently been expanded from three to 19. The variants identified are common and have low penetrance in the general population. The aim of the s...

T. Sparsø, N. Grarup, C. Andreasen, A. Albrechtsen, J. Holmkvist… in Diabetologia (2009)

Article

Variation in the peroxisome proliferator-activated receptor δ gene in relation to common metabolic traits in 7,495 middle-aged white people

Studies in animals reveal that peroxisome proliferator-activated receptor δ (PPARδ) regulates glucose metabolism and insulin sensitivity in both the liver and skeletal muscles. Moreover, PPARδ augments physical e...

N. Grarup, A. Albrechtsen, J. Ek, K. Borch-Johnsen, T. Jørgensen… in Diabetologia (2007)

Article

Studies of the relationship between the ENPP1 K121Q polymorphism and type 2 diabetes, insulin resistance and obesity in 7,333 Danish white subjects

Plasma cell membrane glycoprotein 1 (PC-1) inhibits insulin signalling by direct interaction with the insulin receptor α subunit. This inhibition is enhanced by the minor Q allele of the K121Q polymorphism (rs...

N. Grarup, S. A. Urhammer, J. Ek, A. Albrechtsen, C. Glümer… in Diabetologia (2006)