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Open AccessHealth effects of reduced occupational sedentary behaviour in type 2 diabetes using a mobile health intervention: a study protocol for a 12-month randomized controlled trial—the ROSEBUD study
Short-term trials conducted in adults with type 2 diabetes mellitus (T2DM) showed that reducing sedentary behaviour by performing regular short bouts of light-intensity physical activity enhances health. Moreo...
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Alcoholic beverage preference and diabetes incidence across Europe: the Consortium on Health and Ageing Network of Cohorts in Europe and the United States (CHANCES) project
It is unknown if wine, beer and spirit intake lead to a similar association with diabetes. We studied the association between alcoholic beverage preference and type 2 diabetes incidence in persons who reported...
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Article
Consumption of fatty foods and incident type 2 diabetes in populations from eight European countries
Diets high in saturated and trans fat and low in unsaturated fat may increase type 2 diabetes (T2D) risk, but studies on foods high in fat per unit weight are sparse. We assessed whether the intake of vegetable o...
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Dietary vitamin D intake and risk of type 2 diabetes in the European Prospective Investigation into Cancer and Nutrition: the EPIC-InterAct study
Prospective cohort studies have indicated that serum vitamin D levels are inversely related to risk of type 2 diabetes. However, such studies cannot determine the source of vitamin D. Therefore, we examined th...
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Worse glycaemic control in LADA patients than in those with type 2 diabetes, despite a longer time on insulin therapy
Our aim was to study whether glycaemic control differs between individuals with latent autoimmune diabetes in adults (LADA) and patients with type 2 diabetes, and whether it is influenced by time on insulin th...
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Open AccessExome sequencing-driven discovery of coding polymorphisms associated with common metabolic phenotypes
Human complex metabolic traits are in part regulated by genetic determinants. Here we applied exome sequencing to identify novel associations of coding polymorphisms at minor allele frequencies (MAFs) >1% with...
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Fruit and vegetable intake and type 2 diabetes: EPIC-InterAct prospective study and meta-analysis
Fruit and vegetable intake (FVI) may reduce the risk of type 2 diabetes (T2D), but the epidemiological evidence is inconclusive. The aim of this study is to examine the prospective association of FVI with T2D ...
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Article
Heat shock protein 27 is associated with better nerve function and fewer signs of neuropathy
High levels of serum heat shock protein 27 (sHSP27) have been associated with distal symmetric polyneuropathy in patients with type 1 diabetes. Our objective was to investigate the association between sHSP27, ...
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Article
Food intake of individuals with and without diabetes across different countries and ethnic groups
Given the importance of nutrition therapy in diabetes management, we hypothesized that food intake differs between individuals with and without diabetes. We investigated this hypothesis in two large prospectiv...
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Open AccessEvaluating the discriminative power of multi-trait genetic risk scores for type 2 diabetes in a northern Swedish population
We determined whether single nucleotide polymorphisms (SNPs) previously associated with diabetogenic traits improve the discriminative power of a type 2 diabetes genetic risk score.
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Latent autoimmune diabetes in adults (LADA) is dead: long live autoimmune diabetes!
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Article
Higher leptin levels in Asian Indians than Creoles and Europids: a potential explanation for increased metabolic risk
Leptin predicts cardiovascular diseases and type 2 diabetes, diseases to which Asian Indians are highly susceptible. As a risk marker, leptin's intra-individual and seasonal stability is unstudied and only sma...
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Replication of the association between variants in WFS1 and risk of type 2 diabetes in European populations
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Replication of the association between variants in WFS1 and risk of type 2 diabetes in European populations
Mutations at the gene encoding wolframin (WFS1) cause Wolfram syndrome, a rare neurological condition. Associations between single nucleotide polymorphisms (SNPs) at WFS1 and type 2 diabetes have recently been re...
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Article
Latent autoimmune diabetes in adults (LADA) should be less latent
‘Latent autoimmune diabetes in adults’ (LADA) is the term coined to describe adults who have a slowly progressive form of autoimmune or type 1 diabetes that can be treated initially without insulin injections....
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Conformation-dependent GAD65 autoantibodies in diabetes
Conformation-dependent autoantibodies directed against GAD65 are markers of Type 1 diabetes. In this study we aimed to determine whether the substitution of GAD65 with GAD67 amino acids would affect the bindin...
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40th EASD Annual Meeting of the European Association for the Study of Diabetes
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Glutamate decarboxylase (GAD65) and tyrosine phosphatase-like protein (IA-2) autoantibodies index in a regional population is related to glucose intolerance and body mass index
Aims/hypothesis. Our aims were to investigate the concentrations and prevalence of autoantibodies against the Mr 65.000 isoform of glutamate decarboxylase (GAD65) and the tyrosine phosphatase-lik...
