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Open AccessMyocardial injury defined as elevated high-sensitivity cardiac troponin T is associated with higher mortality in patients seeking care at emergency departments with acute dyspnea
Elevated levels of cardiac troponin T has been observed in patients seeking care at the emergency department (ED) presenting with chest pain but without myocardial infarction (MI). The clinical importance of t...
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Open AccessTNFR1 is associated with short-term mortality in patients with diabetes and acute dyspnea seeking care at the emergency department
Circulating levels of TNF alpha receptor 1 (TNFR1) and 2 (TNFR2) are associated with increased long-term mortality and impaired kidney function.
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Open AccessHigh circulating levels of midregional proenkephalin A predict vascular dementia: a population-based prospective study
Midregional Pro-enkephalin A (MR-PENK A) and N-terminal Protachykinin A (NT-PTA) have been associated with vascular dementia. However, the longitudinal relationship between these biomarkers and incident dement...
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Open AccessThe association between plasma proneurotensin and glucose regulation is modified by country of birth
The prevalence of type 2 diabetes (T2D) has increased dramatically in Middle Eastern populations that represent the largest non-European immigrant group in Sweden today. As proneurotensin predicts T2D, the aim...
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A genetic risk score for hypertension is associated with risk of thoracic aortic aneurysm
A genetic risk score (GRS) based on 29 single nucleotide polymorpysms (SNPs) associated with high blood pressure (BP) was prospectively associated with development of hypertension, stroke and cardiovascular ev...
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Association between systemic leptin and neurotensin concentration in adult individuals with and without type 2 diabetes mellitus
Leptin is an adipokine which regulates appetite and energy balance through a mechanism partially mediated by neurotensin (NT) in central nervous system. Besides acting as a neurotransmitter, NT is expressed i...
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Open AccessESICM LIVES 2016: part two
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Open AccessInverse relationship between a genetic risk score of 31 BMI loci and weight change before and after reaching middle age
Genome-wide-association studies have identified numerous body mass index (BMI)-associated variants, but it is unclear how these relate to weight gain in adults at different ages.
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Novel and established anthropometric measures and the prediction of incident cardiovascular disease: a cohort study
The aim of this study was to compare novel and established anthropometrical measures in their ability to predict cardiovascular disease (CVD), and to determine whether they improve risk prediction beyond class...
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Open AccessCopeptin, a marker of vasopressin, in abdominal obesity, diabetes and microalbuminuria: the prospective Malmö Diet and Cancer Study cardiovascular cohort
High plasma copeptin (copeptin), the C-terminal fragment of arginine vasopressin pro-hormone, has been associated with the metabolic syndrome (MetS), diabetes mellitus (DM) development and nephropathy. Here we...
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4.2 Chromosome 2q12: the Adrenergic Receptor 2b (ADRA2b) Gene and Metabolic Syndrome in Swedish — is there a Link?
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4.3 The V433M Variant of the CYP4F2 is Associated with Ischemic Stroke in Male Swedish Beyond its Effect on Blood Pressure
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Heritability of the ambulatory arterial stiffness index in Swedish families
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3.1 Heritability of the Ambulatory Arterial Stiffness Index in Swedish Families
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Oesophageal dysmotility, delayed gastric emptying and autonomic neuropathy correlate to disturbed glucose homeostasis
Among diabetic patients, glucose homeostasis may be affected by abnormal gastrointestinal motility and autonomic neuropathy. This study analysed whether oesophageal dysmotility, delayed gastric emptying or aut...
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Pro-opiomelanocortin gene is associated with serum leptin levels in lean but not in obese individuals
OBJECTIVE: Mutations in the pro-opiomelanocortin and melanocortin 4 receptor genes (POMC and MC4R) cause monogenic obesity, and the POMC locus (2p21) has been linked to leptin levels and body mass index (BMI). We...
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Association between a variant in the 11β-hydroxysteroid dehydrogenase type 2 gene and primary hypertension
The enzyme 11β-hydroxysteroid dehydrogenase type 2 (11BHSD2) converts cortisol to cortisone in the kidney, thereby protecting the mineralocorticoid receptor from the mineralocorticoid actions of cortisol. The ...
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Role of the Gly460Trp polymorphism of the α-adducin gene in primary hypertension in Scandinavians
Previous studies have suggested that the Trp460 allele of the Gly460Trp polymorphism in the α-adducin gene is associated with salt sensitivity and primary hypertension. The present study was undertaken to eval...
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Pharmacokinetic interactions of alcohol and acetylsalicylic acid
This study assessed the influence of acetylsalicylic acid (ASA, 1.0 g), ibuprofen (0.8 g) and paracetamol (1.0 g) on the single-dose kinetics of ethanol in 12 healthy volunteers ingesting the drug and a standa...