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Article
The disturbance of the distribution of T helper cell subsets in the mantle area surrounding germinal centers in immunoglobulin G4–related sclerosing sialadenitis
The function of germinal centers (GCs) is an important factor in the pathogenesis of immunoglobulin G4 (IgG4)–related disease, in which inflammatory and fibrotic processes are controlled by type 2 helper T (Th...
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Article
Regional disturbance of the distribution of T regulatory cells and T helper cells associated with irregular-shaped germinal centers in immunoglobulin G4-related sialadenitis
Although many germinal centers (GCs) have been reported in immunoglobulin (Ig) G4-related disease, the significance of GCs in IgG4-related disease has not received attention. Both T follicular regulatory cells...
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Article
Open AccessPancreatic acinar cell carcinoma with extension into the main pancreatic duct: a case report
Pancreatic acinar cell carcinoma (PACC) is a rare exocrine malignant tumor. Its widespread intraductal extension into the main pancreatic duct (MPD) is also rare.
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Article
Optimal treatments for TAFRO syndrome: a retrospective surveillance study in Japan
TAFRO syndrome is a systemic inflammatory disorder of unknown etiology characterized by thrombocytopenia, anasarca, fever, reticulin myelofibrosis, renal dysfunction, and organomegaly. Mortality in patients wi...
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Article
Open AccessEarly-stage multi-differentiated gastric carcinosarcoma and post-resection local recurrence: a case report
Carcinosarcoma is a rare neoplasm with a poor prognosis that is most often discovered at an advanced stage; a gastric carcinosarcoma is even rarer than carcinosarcomas originating in other organs, such as the ...
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Article
Open AccessArteriovenous malformation that caused prolapse of the colon and was treated surgically in an infant: a case report
Various terms have been used to describe vascular lesions in the intestine, including angiodysplasia, arteriovenous malformation, and telangiectasia. Such lesions are common in adults and are typified by angio...
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Article
2019 Updated diagnostic criteria and disease severity classification for TAFRO syndrome
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Article
The clinicopathological analysis of receptor tyrosine kinases in meningiomas: the expression of VEGFR-2 in meningioma was associated with a higher WHO grade and shorter progression-free survival
WHO grade II/III meningiomas recur frequently and there is currently no established molecular target therapy for meningioma. No previous studies have revealed the association between receptor tyrosine kinases ...
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Article
Open AccessA case report of infantile cystic nephroblastoma
Nephroblastoma (NB) is a malignant embryonal neoplasm derived from nephrogenic blastemal cells. NB usually forms a solid mass, but in extremely rare cases, it may show cystic changes.
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Article
Open AccessCytopathological findings of proliferating pilomatricoma misdiagnosed as a malignant parotid gland tumor
Pilomatricoma is a relatively common benign cutaneous adnexal neoplasm with differentiation towards the hair matrix, inner sheath of hair follicle and hair cortex. Proliferating pilomatricoma is a rare variant...
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Article
Open AccessAn autopsy case of peripheral T cell lymphoma occurring in a postpartum woman: a unique case suggesting changes in the immunocharacteristics of lymphoma cells before and after delivery
The occurrence of malignant lymphoma after delivery is an extremely rare event. Although several cases of Hodgkin lymphoma and B cell lymphoma and a few cases of peripheral T cell lymphoma (PTCL) after deliver...
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Article
Open AccessAmiodarone-induced reversible and irreversible hepatotoxicity: two case reports
Amiodarone is a highly effective treatment for supraventricular and ventricular tachyarrhythmia; however, it could be associated with several serious adverse effects, including liver injury.
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Article
Open AccessInfective endocarditis following tumor necrosis factor-α antagonist therapy for management of psoriatic erythroderma: a case report
The introduction of biological agents, such as infliximab, which act against tumor necrosis factor-α was a major advance for the treatment of an increasing number of chronic diseases. Tumor necrosis factor-α a...
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Article
Proposed diagnostic criteria, disease severity classification and treatment strategy for TAFRO syndrome, 2015 version
TAFRO syndrome is a systemic inflammatory disorder characterized by thrombocytopenia, anasarca including pleural effusion and ascites, fever, renal insufficiency, and organomegaly including hepatosplenomegaly ...
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Article
A case of IgG4-related kidney disease complicated by eosinophilic lung disease
IgG4-related disease is a systemic chronic inflammatory disorder characterized by a high blood level of IgG4 and the organ injuries by marked infiltration of IgG4-positive plasma cells and fibrosis. A 71-year-...
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Article
NAB2–STAT6 fusion gene analysis in two cases of meningeal solitary fibrous tumor/hemangiopericytoma with late distant metastases
We present two cases of meningeal solitary fibrous tumor (SFT)/hemangiopericytoma (HPC) with immunohistochemistry of STAT6 and analysis of NAB2–STAT6 fusion genes. Case 1 was a 37-year-old male with a left mid...
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Chapter
Other Organs (Central Nervous System, Prostate)
IgG4-related disease (IgG4-RD) is a systemic lymphoproliferative disease characterized by elevated serum IgG4 values and increased numbers of IgG4-producing plasmacytic cells in tissues. Lesions may develop at...
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Article
Open AccessA novel clinical entity, IgG4-related disease (IgG4RD): general concept and details
IgG4-related disease (IgG4RD) is a novel clinical disease entity characterized by elevated serum IgG4 concentration and tumefaction or tissue infiltration by IgG4-positive plasma cells. IgG4RD may be present i...
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Article
High-dose methotrexate with R-CHOP therapy for the treatment of patients with primary central nervous system lymphoma
We describe MR-CHOP therapy, a novel treatment regimen consisting of high-dose methotrexate and R-CHOP that provides systemic anti-tumor activity with penetration of the blood–brain barrier in patients with ne...
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Article
Laparoscopic enucleation of a gastroenteric duplication cyst arising in a pancreatic tail that did not communicate with the pancreatic duct: Report of a case
Gastroenteric duplication rarely occurs in locations such as the pancreas. We report a case of gastroenteric duplication of the pancreatic tail, which was noncontiguous with the stomach and had no communicatio...
