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Article
Open AccessDetection of polyreactive immunoglobulin G facilitates diagnosis in children with autoimmune hepatitis
The detection of autoantibodies is essential to diagnose autoimmune hepatitis (AIH). Particularly in children, specificity of autoantibodies decreases due to lower titers being diagnostic and being present not...
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Article
Open AccessIncreased seroprevalence of HAV and parvovirus B19 in children and of HEV in adults at diagnosis of autoimmune hepatitis
Preceding viral infections have mostly been described in autoimmune hepatitis (AIH) in single cases. We aimed to identify viral infections that potentially trigger AIH, as suggested for hepatitis E virus (HEV)...
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Article
Open AccessImmune monitoring after pediatric liver transplantation – the prospective ChilSFree cohort study
Although trough levels of immunosuppressive drugs are largely used to monitor immunosuppressive therapy after solid organ transplantation, there is still no established tool that allows for a validated assessm...
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Article
Open AccessBaseline IL-2 and the AIH score can predict the response to standard therapy in paediatric autoimmune hepatitis
Although autoimmune hepatitis (AIH) can be treated with corticosteroid-based first-line therapy, incomplete remission is associated with progressive liver fibrosis. So far accepted predictors of the subsequent...
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Article
Human leucocyte antigens and pediatric autoimmune liver disease: diagnosis and prognosis
An association of human leukocyte antigen (HLA) class II alleles with autoimmune conditions is increasingly being used for diagnostic purposes. The aim of our study was to examine whether HLA class II alleles ...
