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  1. Article

    Open Access

    Splenectomy induces biochemical remission and regeneration in experimental murine autoimmune hepatitis

    Autoimmune hepatitis (AIH) is a chronic immune-mediated inflammatory liver disease. It is known that AIH originates not from the spleen but from the liver itself. Nonetheless, most details of the etiology and ...

    Janine Dywicki, Laura Elisa Buitrago-Molina… in European Journal of Medical Research (2022)

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  2. Article

    Open Access

    CD20/CD79a/PAX5/CD3-negative post-transplant lymphoma with aberrant actin and desmin co-expression—a potential differential diagnostic pitfall between PTLD and PTSMT

    Jan-Theile Suhren, Jerome Schlué, Hans Kreipe, Kais Hussein in Annals of Hematology (2022)

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  3. Article

    Open Access

    Genome-wide DNA methylation profiling is able to identify prefibrotic PMF cases at risk for progression to myelofibrosis

    Patients suffering from the BCR-ABL1-negative myeloproliferative disease prefibrotic primary myelofibrosis (pre-PMF) have a certain risk for progression to myelofibrosis. Accurate risk estimation for this fibroti...

    Ulrich Lehmann, Helge Stark, Stephan Bartels, Jerome Schlue… in Clinical Epigenetics (2021)

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  4. No Access

    Article

    Mutations associated with age-related clonal hematopoiesis in PMF patients with rapid progression to myelofibrosis

    Besides histopathological findings there are no indicators of increased risk for fibrotic progression in myeloproliferative neoplasms (MPN). Age-related clonal hematopoiesis (ARCH/CHIP) is a frequent finding in t...

    Stephan Bartels, Muhammad Faisal, Guntram Büsche, Jerome Schlue… in Leukemia (2020)

  5. Article

    Open Access

    Baseline IL-2 and the AIH score can predict the response to standard therapy in paediatric autoimmune hepatitis

    Although autoimmune hepatitis (AIH) can be treated with corticosteroid-based first-line therapy, incomplete remission is associated with progressive liver fibrosis. So far accepted predictors of the subsequent...

    Jana Diestelhorst, Norman Junge, Danny Jonigk, Jerome Schlue… in Scientific Reports (2018)

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  6. No Access

    Article

    Human leucocyte antigens and pediatric autoimmune liver disease: diagnosis and prognosis

    An association of human leukocyte antigen (HLA) class II alleles with autoimmune conditions is increasingly being used for diagnostic purposes. The aim of our study was to examine whether HLA class II alleles ...

    Norman Junge, Miriam Tiedau, Murielle Verboom… in European Journal of Pediatrics (2016)

  7. No Access

    Article

    Thrombospondin-1 (TSP-1) in primary myelofibrosis (PMF) — a megakaryocyte-derived biomarker which largely discriminates PMF from essential thrombocythemia

    Primary myelofibrosis (PMF) is a chronic myeloproliferative neoplasm showing aberrant bone marrow remodeling with increased angiogenesis, progressive matrix accumulation, and fibrosis development. Thrombospond...

    Michaela Muth, Bianca M. Engelhardt, Nicolaus Kröger, Kais Hussein… in Annals of Hematology (2011)

  8. No Access

    Article

    Reduced expression of H19 in bone marrow cells from chronic myeloproliferative disorders

    Oliver Bock, Jerome Schlué, Hans Kreipe in Leukemia (2003)