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  1. Article

    Open Access

    Establishment of a new initial dose plan for vancomycin using the generalized linear mixed model

    When administering vancomycin hydrochloride (VCM), the initial dose is adjusted to ensure that the steady-state trough value (Css-trough) remains within the effective concentration range. However, the Css-trou...

    Yasuyuki Kourogi, Kenji Ogata, Norito Takamura… in Theoretical Biology and Medical Modelling (2017)

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    Article

    A novel injection strategy of flurbiprofen axetil by inhibiting protein binding with 6-methoxy-2-naphthylacetic acid

    Flurbiprofen axetil (FPA) is an injection product and a prodrug of a non-steroidal anti-inflammatory drug (NSAID). After injection, it is rapidly hydrolyzed to the active form, flurbiprofen (FP). Since frequen...

    Kenji Ogata, Norito Takamura, ** Tokunaga… in European Journal of Drug Metabolism and Ph… (2016)

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    Article

    Usefulness of competitive inhibitors of protein binding for improving the pharmacokinetics of 186Re-MAG3-conjugated bisphosphonate (186Re-MAG3-HBP), an agent for treatment of painful bone metastases

    We have developed a 186Re-mercaptoacetylglycylglycylglycine complex-conjugated bisphosphonate (186Re-MAG3-HBP) for the treatment of painful bone metastases. We assumed competitive inhibitors of protein binding to...

    Kazuma Ogawa, Takahiro Mukai, Keiichi Kawai… in European Journal of Nuclear Medicine and M… (2009)

  4. No Access

    Article

    Effect of P-Glycoprotein Modulator, Cyclosporin A, on the Gastrointestinal Excretion of Irinotecan and Its Metabolite SN-38 in Rats

    Purpose. The purpose of this work was to investigate the role of the hepatic and intestinal P-glycoprotein (P-gp) and canalicular multispecific organic anion transporter /multidrug resistance-associated protein ...

    Kazuhiko Arimori, Noriaki Kuroki, Muneaki Hidaka, Tomomi Iwakiri… in Pharmaceutical Research (2003)

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    Article

    Interactions of Aldosterone Antagonist Diuretics with Human Serum Proteins

    Purpose. The purpose of this study was to investigate the binding mechanism of aldosterone antagonist diuretics with human serum proteins, human serum albumin (HSA) and α1-acid glycoprotein (AGP), as well as to ...

    Norito Takamura, Toru Maruyama, Shamim Ahmed, Ayaka Suenaga… in Pharmaceutical Research (1997)

  6. No Access

    Article

    Mode of Interaction of Loop Diuretics with Human Serum Albumin and Characterization of Binding Site

    Purpose. The purpose of this study was to investigate the binding mechanism of loop diuretics with HSA and to characterize the binding site on HSA.

    Norito Takamura, Akihiko Haruta, Hirofumi Kodama… in Pharmaceutical Research (1996)

  7. No Access

    Article

    Interaction of Benzothiadiazides with Human Serum Albumin Studied by Dialysis and Spectroscopic Methods

    The interaction of a series of benzothiadiazides with human serum albumin (HSA) was investigated by equilibrium dialysis (ED) and spectroscopic methods including circular dichroism (CD). The primary binding si...

    Norito Takamura, Mohamed Habibur Rahman, Keishi Yamasaki… in Pharmaceutical Research (1994)