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  1. No Access

    Article

    In Vitro and In Vivo Assessment of Atemoya Fruit (Annona atemoya) for Food–Drug Interactions

    Atemoya (Annona atemoya) is increasingly being consumed worldwide because of its pleasant taste. However, only limited information is available concerning possible atemoya–drug interactions. In the present study,...

    Keishi Yamasaki, Masahiro Fujisaki-Hirakawa… in European Journal of Drug Metabolism and Ph… (2022)

  2. No Access

    Chapter

    Serum Albumin, Lipid and Drug Binding

    conserved from vertebrates to , and nature of mammalian permit them to bind various endogenous ligands and drugs in the blood. It is known that at least two major ligand are present on the molecule...

    Koji Nishi, Keishi Yamasaki, Masaki Otagiri in Vertebrate and Invertebrate Respiratory Pr… (2020)

  3. No Access

    Article

    Investigation of anti-tumor effect of doxorubicin-loaded human serum albumin nanoparticles prepared by a desolvation technique

    Nanoparticles of human serum albumin (HSA) prepared using a desolvation method possess sizes suitable for tumor accumulation. Here, we report on an investigation of the anti-tumor effects and biodistribution o...

    Kotaro Kimura, Keishi Yamasaki, Koji Nishi… in Cancer Chemotherapy and Pharmacology (2019)

  4. No Access

    Chapter

    Stability of Albumin and Stabilization of Albumin Preparations

    Human serum albumin (HSA) is structurally stabilized by 17 disulfide bonds, and interactions between domains (or subdomains) of HSA also contribute to its stability. The effects of several other factors on the...

    Keishi Yamasaki, Makoto Anraku in Albumin in Medicine (2016)

  5. No Access

    Article

    3ircular dichroism simulation shows a site-II-to-site-I displacement of human serum albumin-bound diclofenac by ibuprofen

    Purpose: The purpose of this study was to confirm the hypothesis that a site-II-to-site-I displacement takes place when some nonsteroidal anti-inflammatory drugs are displaced by another drug fro...

    Keishi Yamasaki, Mohammed Hablbur Rahman, Yasuhiro Tsutsumi… in AAPS PharmSciTech (2015)

  6. No Access

    Article

    Adsorption of irinotecan onto oral adsorbent AST-120 (KremezinTM) for preventing delayed diarrhea

    One of the significant dose-limiting toxicities of irinotecan hydrochloride (CPT-11) is severe diarrhea due to impairment of the intestinal membrane induced by the excreted CPT-11 and its metabolites. AST-120 ...

    Muneaki Hidaka, Keishi Yamasaki, Manabu Okumura… in Cancer Chemotherapy and Pharmacology (2007)

  7. No Access

    Article

    Effect of P-Glycoprotein Modulator, Cyclosporin A, on the Gastrointestinal Excretion of Irinotecan and Its Metabolite SN-38 in Rats

    Purpose. The purpose of this work was to investigate the role of the hepatic and intestinal P-glycoprotein (P-gp) and canalicular multispecific organic anion transporter /multidrug resistance-associated protein ...

    Kazuhiko Arimori, Noriaki Kuroki, Muneaki Hidaka, Tomomi Iwakiri… in Pharmaceutical Research (2003)

  8. No Access

    Article

    In Vitro and in Vivo Properties of Recombinant Human Serum Albumin from Pichia Pastoris Purified by a Method of Short Processing Time

    Purpose. Recombinant human serum albumin (rHSA), secreted by a Pichia pastorisexpression system, was purified by a fast and efficient method, the essential feature of which is strong but reversible binding of th...

    Hiroshi Watanabe, Keishi Yamasaki, Ulrich Kragh-Hansen… in Pharmaceutical Research (2001)

  9. No Access

    Article

    Effect of Oxidative Stress on the Structure and Function of Human Serum Albumin

    Purpose. Human serum albumin (HSA) was mildly oxidized by a metal–catalyzed oxidation system (MCO–HSA), chloramine–T (CT–HSA) or H2O2 (H2O2–HSA), and the effects of these treatments on the structural, drug–bindi...

    Makoto Anraku, Keishi Yamasaki, Toru Maruyama… in Pharmaceutical Research (2001)

  10. No Access

    Article

    Interaction Mechanism Between Indoxyl Sulfate, a Typical Uremic Toxin Bound to Site II, and Ligands Bound to Site I of Human Serum Albumin

    Purpose. The study was performed for clarifying the mechanism of interaction between indoxyl sulfate (IS), a typical uremic toxin bound to site II, and site I-ligands when bound to human serum albumin (HSA). The...

    Toshiaki Sakai, Keishi Yamasaki, Tomoko Sako… in Pharmaceutical Research (2001)

  11. No Access

    Article

    Mode of Interaction of Loop Diuretics with Human Serum Albumin and Characterization of Binding Site

    Purpose. The purpose of this study was to investigate the binding mechanism of loop diuretics with HSA and to characterize the binding site on HSA.

    Norito Takamura, Akihiko Haruta, Hirofumi Kodama… in Pharmaceutical Research (1996)

  12. No Access

    Article

    Interaction of Benzothiadiazides with Human Serum Albumin Studied by Dialysis and Spectroscopic Methods

    The interaction of a series of benzothiadiazides with human serum albumin (HSA) was investigated by equilibrium dialysis (ED) and spectroscopic methods including circular dichroism (CD). The primary binding si...

    Norito Takamura, Mohamed Habibur Rahman, Keishi Yamasaki… in Pharmaceutical Research (1994)