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  1. No Access

    Article

    New methodology of simple and accurate external markers for stock identification of ayu in a tributary of the Miya River, Mie, Japan

    We investigated the sizes of scales above the lateral line in wild and hatchery-reared ayu in the Ouchiyama River, a tributary of the Miya River, to determine useful external markers for stock identification. ...

    Atsuya Yamamoto, Tamami Hattori, Marina Ito, Takahito Masubuchi in Fisheries Science (2023)

  2. No Access

    Article

    Bayesian and Neural Network Approaches to Estimate Deep Temperature Distribution for Assessing a Supercritical Geothermal System: Evaluation Using a Numerical Model

    The temperature distribution at depth is a key variable when assessing the potential of a supercritical geothermal resource as well as a conventional geothermal resource. Data-driven estimation by a machine-le...

    Kazuya Ishitsuka, Yosuke Kobayashi, Norihiro Watanabe in Natural Resources Research (2021)

  3. No Access

    Article

    Numerical modeling of two-phase flow in deformable porous media: application to CO \(_2\) injection analysis in the Otway Basin, Australia

    We examined the two-phase hydro-mechanical coupled process for subsurface applications. First, we exclusively derived governing equations for capillary pressure of the wetting fluid and pressure of the non-wet...

    Taehyun Kim, Chan-Hee Park, Norihiro Watanabe in Environmental Earth Sciences (2021)

  4. No Access

    Article

    Engineered off-the-shelf therapeutic T cells resist host immune rejection

    Engineered T cells are effective therapies against a range of malignancies, but current approaches rely on autologous T cells, which are difficult and expensive to manufacture. Efforts to develop potent alloge...

    Feiyan Mo, Norihiro Watanabe, Mary K. McKenna, M. John Hicks in Nature Biotechnology (2021)

  5. Article

    Open Access

    Expanding CAR T cells in human platelet lysate renders T cells with in vivo longevity

    Pre-clinical and clinical studies have shown that the infusion of CAR T cells with a naive-like (TN) and central memory (TCM) phenotype is associated with prolonged in vivo T cell persistence and superior anti-tu...

    Alejandro Torres Chavez, Mary Kathryn McKenna in Journal for ImmunoTherapy of Cancer (2019)

  6. Article

    Open Access

    CAR T cell therapy for breast cancer: harnessing the tumor milieu to drive T cell activation

    The adoptive transfer of T cells redirected to tumor via chimeric antigen receptors (CARs) has produced clinical benefits for the treatment of hematologic diseases. To extend this approach to breast cancer, we...

    Pradip Bajgain, Supannikar Tawinwung, Lindsey D’Elia in Journal for ImmunoTherapy of Cancer (2018)

  7. No Access

    Chapter

    RTM Processes

    Fluid-mineral interaction, over the fracture surface, renders a permanent change of fracture surface geometry. Hydraulic characteristic of fracture is consequently altered in response to the geometric ch...

    Renchao Lu, Norihiro Watanabe, Eunseon Jang in Thermo-Hydro-Mechanical-Chemical Processes… (2018)

  8. No Access

    Chapter

    HM Processes

    This on coupled hydraulic–mechanical processes in a fault zone. The benchmark is motivated by the “Fault Slip (FS)” of the Mont Terri Project. In this experiment, a fluid injection into a fault is ca...

    Gesa Ziefle, Jobst Maßmann in Thermo-Hydro-Mechanical-Chemical Processes… (2018)

  9. No Access

    Chapter

    HT (Convection) Processes

    In a geothermal system, unstable fluid density profiles due to temperature variations can trigger the onset and development of free thermal convective processes (J.W. Elder. Transient convection in a porous me...

    Fabien Magri, Mauro Cacace, Thomas Fischer in Thermo-Hydro-Mechanical-Chemical Processes… (2018)

  10. No Access

    Article

    Calibration of water–granite interaction with pressure solution in a flow-through fracture under confining pressure

    Fluid–mineral interaction has an irreversible impact on the fracture permeability evolution in the life span of deep geological reservoirs. To investigate the impact, a preliminary study on water–granite inter...

    Renchao Lu, Norihiro Watanabe, Wenkui He, Eunseon Jang in Environmental Earth Sciences (2017)

  11. No Access

    Book

  12. No Access

    Chapter

    Theory

    This chapter briefly glances at the basic theory of enhanced geothermal reservoir modeling, specifically hydraulic and thermal processes in fractured geological systems, and their numerical solutions with the ...

    Norihiro Watanabe, Guido Blöcher, Mauro Cacace, Sebastian Held in Geoenergy Modeling III (2017)

  13. No Access

    Chapter

    Benchmarks

    This chapter presents several benchmark examples for demonstrating basics of how to set up OpenGeoSys input files for EGS reservoir modeling and check simulation results mainly using ParaView. Meshes are prepared...

    Norihiro Watanabe, Guido Blöcher, Mauro Cacace, Sebastian Held in Geoenergy Modeling III (2017)

  14. No Access

    Chapter

    Case Study: Soultz-sous-Forêts

    The second case study is given for Soultz-sous-Forêts site in France, which represents an enhanced hydrothermal type of EGS reservoirs. Input files for the simulations are available from https:...

    Norihiro Watanabe, Guido Blöcher, Mauro Cacace, Sebastian Held in Geoenergy Modeling III (2017)

  15. No Access

    Chapter

    Introduction

    Welcome to the third volume of the Geoenergy Modeling series. This volume will introduce the reader to the field of modeling enhanced geothermal reservoirs. In this first chapter, we will briefly introduce Enh...

    Norihiro Watanabe, Guido Blöcher, Mauro Cacace, Sebastian Held in Geoenergy Modeling III (2017)

  16. No Access

    Chapter

    Open-Source Software

    Software used in the later benchmark examples and case studies are introduced. All of them are open-source and freely available for scientific research purposes.

    Norihiro Watanabe, Guido Blöcher, Mauro Cacace, Sebastian Held in Geoenergy Modeling III (2017)

  17. No Access

    Chapter

    Case Study: Groß Schönebeck

    In the following two chapters, we demonstrate how the numerical simulation can be applied to actual reservoir analysis. The first case study is given for the Groß Schönebeck research site in Germany, which rep...

    Norihiro Watanabe, Guido Blöcher, Mauro Cacace, Sebastian Held in Geoenergy Modeling III (2017)

  18. No Access

    Book

    Geoenergy Modeling I

    Geothermal Processes in Fractured Porous Media

    Norbert Böttcher, Norihiro Watanabe, Uwe-Jens Görke in SpringerBriefs in Energy (2016)

  19. No Access

    Chapter

    Geothermal Energy

    Welcome to the OGS HIGRADE Tutorials on Computational Energy Systems. The first tutorial will introduce the reader to the field of modeling geothermal energy systems. In the beginning chapter we will introduce...

    Norbert Böttcher, Norihiro Watanabe, Uwe-Jens Görke, Olaf Kolditz in Geoenergy Modeling I (2016)

  20. No Access

    Chapter

    Numerical Methods

    There are many alternative methods to solve initial-boundary-value problems arising from flow and transport processes in subsurface systems. In general these methods can be classified into analytical and numer...

    Norbert Böttcher, Norihiro Watanabe, Uwe-Jens Görke, Olaf Kolditz in Geoenergy Modeling I (2016)

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