11 Result(s)
within
Noam Shoresh
Science, Humanities and Social Sciences, multidisciplinary
English
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Article
Open AccessAuthor Correction: Expanded encyclopaedias of DNA elements in the human and mouse genomes
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Article
Open AccessDetecting sample swaps in diverse NGS data types using linkage disequilibrium
As the number of genomics datasets grows rapidly, sample mislabeling has become a high stakes issue. We present CrosscheckFingerprints (Crosscheck), a tool for quantifying sample-relatedness and detecting inco...
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Article
Open AccessExpanded encyclopaedias of DNA elements in the human and mouse genomes
The human and mouse genomes contain instructions that specify RNAs and proteins and govern the timing, magnitude, and cellular context of their production. To better delineate these elements, phase III of the ...
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Article
Open AccessHybridization-based capture of pathogen mRNA enables paired host-pathogen transcriptional analysis
Dual transcriptional profiling of host and bacteria during infection is challenging due to the low abundance of bacterial mRNA. We report Pathogen Hybrid Capture (PatH-Cap), a method to enrich for bacterial mR...
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Open AccessRapid identification and phylogenetic classification of diverse bacterial pathogens in a multiplexed hybridization assay targeting ribosomal RNA
Rapid bacterial identification remains a critical challenge in infectious disease diagnostics. We developed a novel molecular approach to detect and identify a wide diversity of bacterial pathogens in a single...
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Article
Polyploidy can drive rapid adaptation in yeast
In vitro evolution experiments on haploid, diploid, and tetraploid yeast strains show that adaptation is faster in tetraploids, providing direct quantitative evidence that in some environments polyploidy can acce...
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Article
Open AccessIntegrative analysis of 111 reference human epigenomes
The reference human genome sequence set the stage for studies of genetic variation and its association with human disease, but epigenomic studies lack a similar reference. To address this need, the NIH Roadmap...
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Genetic and epigenetic fine map** of causal autoimmune disease variants
Genome-wide association studies have identified loci underlying human diseases, but the causal nucleotide changes and mechanisms remain largely unknown. Here we developed a fine-map** algorithm to identify c...
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Optimization of lag time underlies antibiotic tolerance in evolved bacterial populations
Repeated exposure of the bacterium Escherichia coli to clinically relevant concentrations of ampicillin results in the evolution of tolerance—the ability to survive until the antibiotic concentration diminishes—t...
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Open AccessComparative analysis of metazoan chromatin organization
A large collection of new modENCODE and ENCODE genome-wide chromatin data sets from cell lines and developmental stages in worm, fly and human are analysed; this reveals many conserved features of chromatin or...
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Map** and analysis of chromatin state dynamics in nine human cell types
Chromatin profiling has emerged as a powerful means of genome annotation and detection of regulatory activity. The approach is especially well suited to the characterization of non-coding portions of the genom...
